{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T10:41:52Z","timestamp":1765622512253,"version":"3.48.0"},"reference-count":15,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1998,4,8]]},"published-print":{"date-parts":[[1998,10,1]]},"abstract":"<jats:p>\n                    <jats:italic>Objectives<\/jats:italic>\n                    \u2014Recent studies on coeliac disease have shown that oats can be included in a gluten-free diet without adverse effects on the small bowel. The presence of a rash is also a sensitive indicator of gluten ingestion in dermatitis herpetiformis, and this was used to study whether patients with this disease could also tolerate oats.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Patients\/Methods<\/jats:italic>\n                    \u2014Eleven patients with dermatitis herpetiformis in remission on a gluten-free diet were challenged daily with 50 g oats for six months. Clinical symptoms were recorded, serum samples taken, and skin and small bowel biopsies performed before and after the oat challenge. A control group comprised of 11 patients with dermatitis herpetiformis on a conventional gluten-free diet was also studied.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014Eight patients challenged with oats remained asymptomatic, two developed a transient rash, and one withdrew because of the appearance of a more persistent but mild rash. Three of the 11 controls also developed a transient rash. IgA endomysial antibodies remained negative in all patients. The small bowel villous architecture, the densities of intraepithelial CD3 and \u03b1\/\u03b2 and \u03b3\/\u03b4 T cell receptor positive lymphocytes and crypt epithelial cell DR expression remained unaltered during the oat challenge.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    \u2014The results confirm the absence of oat toxicity on the gluten sensitive small bowel mucosa and suggest that the rash in patients with dermatitis herpetiformis is not activated by eating oats.\n                  <\/jats:p>","DOI":"10.1136\/gut.43.4.490","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"490-493","source":"Crossref","is-referenced-by-count":73,"title":["Tolerance to oats in dermatitis herpetiformis"],"prefix":"10.1136","volume":"43","author":[{"given":"T","family":"Reunala","sequence":"first","affiliation":[{"name":"aDepartments of Dermatology, University and University Hospitals of Tampere and Helsinki, Finland, \n\nbDepartments of Medicine, Paediatrics and Clinical Microbiology, Tampere University Hospital and University of Tampere, \n\ncInstitute of Medical Technology and Medical School, University of Tampere"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Collin","sequence":"additional","affiliation":[{"name":"aDepartments of Dermatology, University and University Hospitals of Tampere and Helsinki, Finland, \n\nbDepartments of Medicine, Paediatrics and Clinical Microbiology, Tampere University Hospital and University of Tampere, \n\ncInstitute of Medical Technology and Medical School, University of Tampere"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Holm","sequence":"additional","affiliation":[{"name":"aDepartments of Dermatology, University and University Hospitals of Tampere and Helsinki, Finland, \n\nbDepartments of Medicine, Paediatrics and Clinical Microbiology, Tampere University Hospital and University of Tampere, \n\ncInstitute of Medical Technology and Medical School, University of Tampere"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Pikkarainen","sequence":"additional","affiliation":[{"name":"aDepartments of Dermatology, University and University Hospitals of Tampere and Helsinki, Finland, \n\nbDepartments of Medicine, Paediatrics and Clinical Microbiology, Tampere University Hospital and University of Tampere, \n\ncInstitute of Medical Technology and Medical School, University of Tampere"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Miettinen","sequence":"additional","affiliation":[{"name":"aDepartments of Dermatology, University and University Hospitals of Tampere and Helsinki, Finland, \n\nbDepartments of Medicine, Paediatrics and Clinical Microbiology, Tampere University Hospital and University of Tampere, \n\ncInstitute of Medical Technology and Medical School, University of Tampere"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Vuolteenaho","sequence":"additional","affiliation":[{"name":"aDepartments of Dermatology, University and University Hospitals of Tampere and Helsinki, Finland, \n\nbDepartments of Medicine, Paediatrics and Clinical Microbiology, Tampere University Hospital and University of Tampere, \n\ncInstitute of Medical Technology and Medical School, University of Tampere"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"M\u00e4ki","sequence":"additional","affiliation":[{"name":"aDepartments of Dermatology, University and University Hospitals of Tampere and Helsinki, Finland, \n\nbDepartments of Medicine, Paediatrics and Clinical Microbiology, Tampere University Hospital and University of Tampere, \n\ncInstitute of Medical Technology and Medical School, University of Tampere"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1998,10,1]]},"reference":[{"key":"2025121302374831000_43.4.490.1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.25.2.151"},{"key":"2025121302374831000_43.4.490.2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.2.206"},{"key":"2025121302374831000_43.4.490.3","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/S0140-6736(73)91539-0","article-title":"Clearance of skin lesions in dermatitis herpetiformis after gluten withdrawal.","volume":"i","author":"Fry","year":"1973","journal-title":"Lancet"},{"key":"2025121302374831000_43.4.490.4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1977.tb14122.x"},{"key":"2025121302374831000_43.4.490.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198304073081406"},{"key":"2025121302374831000_43.4.490.6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199510193331602"},{"key":"2025121302374831000_43.4.490.7","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1136\/bmj.313.7068.1300","article-title":"Absence of oats toxicity in adult coeliac disease.","volume":"313","author":"Srinivasan","year":"1996","journal-title":"BMJ"},{"key":"2025121302374831000_43.4.490.8","unstructured":"K\u00f6ppel E, Stadler M, L\u00fcthy J, et al. Oats and gliadin. In: Collin P, M\u00e4ki M, eds. Abstracts of the Seventh International Symposium on Coeliac Disease; 1996 Sept 5\u20137; Tampere, Finland. Tampere: Lege Antis, 1996. ."},{"key":"2025121302374831000_43.4.490.9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1987.tb04115.x"},{"key":"2025121302374831000_43.4.490.10","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91262-7"},{"key":"2025121302374831000_43.4.490.11","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1136\/gut.35.1.55","article-title":"Immunohistochemical changes in the jejunum of the first degree relatives of patients with coeliac disease and the coeliac disease marker DQ genes. HLA class II antigen expression, interleukin-2 receptor positive cells and dividing crypt cells.","volume":"23","author":"Holm","year":"1994","journal-title":"Gut"},{"key":"2025121302374831000_43.4.490.12","unstructured":"Janatuinen E, Kemppainen T, Kosma V-M, et al. Oats in coeliac diet; a 5-year follow-up study. In: Collin P, M\u00e4ki M, eds. Abstracts of the Seventh International Symposium on Coeliac Disease; 1996 Sept 5\u20137; Tampere, Finland. Tampere: Lege Antis, 1996. ."},{"key":"2025121302374831000_43.4.490.13","doi-asserted-by":"publisher","DOI":"10.3109\/00365528708991895"},{"key":"2025121302374831000_43.4.490.14","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.314.7075.159"},{"key":"2025121302374831000_43.4.490.15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199712253372604"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.43.4.490","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T10:37:52Z","timestamp":1765622272000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.43.4.490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,10,1]]},"references-count":15,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1998,10,1]]},"published-print":{"date-parts":[[1998,10,1]]}},"alternative-id":["10.1136\/gut.43.4.490"],"URL":"https:\/\/doi.org\/10.1136\/gut.43.4.490","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1998,10,1]]}}}