{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T23:01:28Z","timestamp":1765666888115,"version":"3.48.0"},"reference-count":27,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1998,4,3]]},"published-print":{"date-parts":[[1998,10,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014Replication errors (RERs) characterise tumours of hereditary non-polyposis colorectal cancer (HNPCC). RER status may therefore improve identification of such families previously diagnosed by family history alone.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aims<\/jats:italic>\n                    \u2014To assess RER and HNPCC frequency within a population of colorectal cancer patients and a regional population of family history defined (Amsterdam criteria) HNPCC families.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    \u2014Family history was assessed by personal interview in a population of 479 patients with colorectal cancer attending one follow up clinic. Seven fluorescently labelled microsatellites were used to investigate RER frequency in colorectal cancers from 89 patients of this population with varying degrees of family history and 20 Amsterdam criteria positive families (four with a known germline mutation, 16 with unknown mutation status) from the regional population.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014Only four of the follow up population (0.8%) came from families meeting the Amsterdam criteria with only one showing RERs. The frequency of RERs was similar in the early onset cancer group (less than 50 years of age), those with a family history, and those with no family history of colorectal cancer. From the regional population, RERs were identified in 4\/4 families with a mutation but only 8\/16 families with unknown mutation status.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    \u2014No correlation was seen between RER status and strength of family history except in HNPCC families. Results also indicate that half of the Amsterdam criteria defined families do not exhibit RERs, perhaps suggesting a different mechanism of tumorigenesis.\n                  <\/jats:p>","DOI":"10.1136\/gut.43.4.553","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"553-557","source":"Crossref","is-referenced-by-count":8,"title":["Frequency of replication errors in colorectal cancer and their association with family history"],"prefix":"10.1136","volume":"43","author":[{"given":"S R","family":"Brown","sequence":"first","affiliation":[{"name":"aCentre for Digestive Diseases, Leeds General Infirmary, \n\nbDepartment of Molecular Oncology, University of Leeds, \n\ncImperial Cancer Research Fund, Genetic Epidemiology Department, St James\u2019s University Hospital, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P J","family":"Finan","sequence":"additional","affiliation":[{"name":"aCentre for Digestive Diseases, Leeds General Infirmary, \n\nbDepartment of Molecular Oncology, University of Leeds, \n\ncImperial Cancer Research Fund, Genetic Epidemiology Department, St James\u2019s University Hospital, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Cawkwell","sequence":"additional","affiliation":[{"name":"aCentre for Digestive Diseases, Leeds General Infirmary, \n\nbDepartment of Molecular Oncology, University of Leeds, \n\ncImperial Cancer Research Fund, Genetic Epidemiology Department, St James\u2019s University Hospital, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Quirke","sequence":"additional","affiliation":[{"name":"aCentre for Digestive Diseases, Leeds General Infirmary, \n\nbDepartment of Molecular Oncology, University of Leeds, \n\ncImperial Cancer Research Fund, Genetic Epidemiology Department, St James\u2019s University Hospital, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D T","family":"Bishop","sequence":"additional","affiliation":[{"name":"aCentre for Digestive Diseases, Leeds General Infirmary, \n\nbDepartment of Molecular Oncology, University of Leeds, \n\ncImperial Cancer Research Fund, Genetic Epidemiology Department, St James\u2019s University Hospital, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1998,10,1]]},"reference":[{"key":"2025121304401850000_43.4.553.1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800630103"},{"key":"2025121304401850000_43.4.553.2","first-page":"4344","article-title":"Familial aggregation of tumours in the three-year experience of a population based colorectal cancer registry.","volume":"49","author":"Ponz de Leon","year":"1989","journal-title":"Cancer 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