{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T20:06:03Z","timestamp":1772741163189,"version":"3.50.1"},"reference-count":33,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1998,5,13]]},"published-print":{"date-parts":[[1998,11,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014Both acid and duodenal contents are thought to be responsible for the mucosal damage in Barrett\u2019s oesophagus, a condition often treated medically. However, little is known about the effect of omeprazole on duodenogastric reflux (DGR) and duodenogastro-oesophageal reflux (DGOR).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aims<\/jats:italic>\n                    \u2014To study the effect of omeprazole 20 mg twice daily on DGR and DGOR, using the technique of ambulatory bilirubin monitoring.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    \u2014Twenty three patients with Barrett\u2019s oesophagus underwent manometry followed by 24 hour oesophageal and gastric pH monitoring. In conjunction with pH monitoring, 11 patients (group 1) underwent oesophageal bilirubin monitoring and 12 patients (group 2) underwent gastric bilirubin monitoring, both before and during treatment with omeprazole 20 mg twice daily.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014In both groups there was a significant reduction in oesophageal acid (pH&lt;4) reflux (p&lt;0.005) and a significant increase in the time gastric pH was above 4 (p&lt;0.005). In group 1, median total oesophageal bilirubin exposure was significantly reduced from 28.9% to 2.4% (p&lt;0.005). In group 2, median total gastric bilirubin exposure was significantly reduced from 24.9% to 7.2% (p&lt;0.005).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    \u2014Treatment of Barrett\u2019s oesophagus with omeprazole 20 mg twice daily results in a notable reduction in the exposure of the oesophagus to both acid and duodenal contents. In addition, delivery of duodenal contents to the upper gastric body is reduced.\n                  <\/jats:p>","DOI":"10.1136\/gut.43.5.603","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"603-606","source":"Crossref","is-referenced-by-count":77,"title":["Effect of omeprazole 20 mg twice daily on duodenogastric and gastro-oesophageal bile reflux in Barrett\u2019s oesophagus"],"prefix":"10.1136","volume":"43","author":[{"given":"R E K","family":"Marshall","sequence":"first","affiliation":[{"name":"Department of Surgery, Guy\u2019s Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Anggiansah","sequence":"additional","affiliation":[{"name":"Department of Surgery, Guy\u2019s Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D K","family":"Manifold","sequence":"additional","affiliation":[{"name":"Department of Surgery, Guy\u2019s Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W A","family":"Owen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Guy\u2019s Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W J","family":"Owen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Guy\u2019s Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1998,11,1]]},"reference":[{"key":"2025121300480456000_43.5.603.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(95)80015-8"},{"key":"2025121300480456000_43.5.603.2","first-page":"A147","article-title":"An experimental model of Barrett\u2019s oesophagus by bile reflux [abstract].","volume":"106","author":"Nakano","year":"1994","journal-title":"Gastroenterology"},{"key":"2025121300480456000_43.5.603.3","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800750208"},{"key":"2025121300480456000_43.5.603.4","first-page":"209","article-title":"Barrett\u2019s oesophagus: congenital or acquired? 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