{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T19:53:00Z","timestamp":1757620380998,"version":"3.44.0"},"reference-count":19,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1998,5,13]]},"published-print":{"date-parts":[[1998,11,1]]},"abstract":"<jats:p>\n                  <jats:italic>Background<\/jats:italic>\u2014Relatives of patients with early onset colorectal cancer, a feature of hereditary non-polyposis colorectal cancer (HNPCC), are at increased risk of colorectal cancer.<\/jats:p>\n               <jats:p>\n                  <jats:italic>Aims<\/jats:italic>\u2014To investigate risk in relatives of patients with multiple primary cancers, another feature of HNPCC.<\/jats:p>\n               <jats:p>\n                  <jats:italic>Methods<\/jats:italic>\u2014Details were obtained on patients from one region who had developed colorectal cancer and a separate primary from the HNPCC tumour spectrum (colorectal, stomach, urinary, ovary, endometrial). Overall, 157 patients had second primaries occurring between 1990 and 1995 and 128 completed family histories were obtained by structured interview (study group). A comparison group of 444 patients with a single colorectal cancer were similarly interviewed.<\/jats:p>\n               <jats:p>\n                  <jats:italic>Results<\/jats:italic>\u2014Fifteen families (13%) from the study group were suggestive of HNPCC compared with three (0.7%, p&lt;0.0001) from the comparison group. Overall risk of colorectal cancer in close relatives of the study group was 3.4 times the general population rate compared with 1.8 times for the comparison group. Bowel cancer risk was even higher for relatives of bowel\/ovary and bowel\/endometrial subgroups, but was similar to the comparison group for the bowel\/bowel subgroup. Finally, extracolonic HNPCC associated cancers were seen twice as frequently as expected in the general population in relatives of the study group.<\/jats:p>\n               <jats:p>\n                  <jats:italic>Conclusion<\/jats:italic>\u2014This study highlights the importance of taking a family history in patients with multiple primary cancers and indicates the risk of malignancy in their relatives.<\/jats:p>","DOI":"10.1136\/gut.43.5.664","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"664-668","source":"Crossref","is-referenced-by-count":8,"title":["Are relatives of patients with multiple HNPCC spectrum tumours at increased risk of cancer?"],"prefix":"10.1136","volume":"43","author":[{"given":"S R","family":"Brown","sequence":"first","affiliation":[{"name":"aDepartment of Surgery and Centre for Digestive Diseases, Leeds General Infirmary, Leeds, UK, \n\nbImperial Cancer Research Fund, Genetic Epidemiology Laboratory, St James\u2019s Hospital, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P J","family":"Finan","sequence":"additional","affiliation":[{"name":"aDepartment of Surgery and Centre for Digestive Diseases, Leeds General Infirmary, Leeds, UK, \n\nbImperial Cancer Research Fund, Genetic Epidemiology Laboratory, St James\u2019s Hospital, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D T","family":"Bishop","sequence":"additional","affiliation":[{"name":"aDepartment of Surgery and Centre for Digestive Diseases, Leeds General Infirmary, Leeds, UK, \n\nbImperial Cancer Research Fund, Genetic Epidemiology Laboratory, St James\u2019s Hospital, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1998,11,1]]},"reference":[{"key":"2025090723291462000_43.5.664.1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800630103"},{"key":"2025090723291462000_43.5.664.2","first-page":"4344","article-title":"Familial aggregation of tumours in the three-year experience of a population-based colorectal cancer registry.","volume":"49","author":"Ponz de Leon","year":"1989","journal-title":"Cancer Res"},{"key":"2025090723291462000_43.5.664.3","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1002\/bjs.1800781005","article-title":"Frequency of familial colorectal cancer.","volume":"78","author":"Stephenson","year":"1991","journal-title":"Br J Surg"},{"key":"2025090723291462000_43.5.664.4","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90330-S"},{"key":"2025090723291462000_43.5.664.5","first-page":"4590","article-title":"HMSH2 mutations in hereditary nonpolyposis colorectal cancer kindreds.","volume":"54","author":"Liu","year":"1994","journal-title":"Cancer Res"},{"key":"2025090723291462000_43.5.664.6","first-page":"2067","article-title":"Mutation analysis of the hMSH2 gene reveals a three base pair deletion in a family predisposed to colorectal cancer development.","volume":"3","author":"Mary","year":"1995","journal-title":"Hum Mol Genet"},{"key":"2025090723291462000_43.5.664.7","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930201)71:3<677::AID-CNCR2820710305>3.0.CO;2-#"},{"key":"2025090723291462000_43.5.664.8","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1002\/bjs.1800811029","article-title":"Genetic susceptibility to colorectal cancer in patients under 45 years of age.","volume":"81","author":"Hall","year":"1994","journal-title":"Br J Surg"},{"key":"2025090723291462000_43.5.664.9","unstructured":"Joslin C Rider L Round C , eds (1992) Yorkshire Cancer Registry: Report for the year 1991, including cancer statistics for 1984\u20131988. 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