{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:18:55Z","timestamp":1790713135194,"version":"4.1.0"},"reference-count":22,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1998,6,4]]},"published-print":{"date-parts":[[1998,12,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014Intestinal metaplastic mucosa in Barrett\u2019s oesophagus can be replaced by squamous epithelium after mucosal thermal ablation associated with acid suppression therapy.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aims<\/jats:italic>\n                    \u2014To assess whether restoration of squamous epithelium can be obtained after ablation of Barrett\u2019s oesophagus using argon plasma coagulation (APC) associated with proton pump inhibitor (PPI) therapy.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    \u2014Thirty one patients with Barrett\u2019s oesophagus received APC. Omeprazole (40 mg\/day) was given from the first APC application to one month after completion of the treatment, then given symptomatically. Twenty four hour pH-metry was performed during endotherapy.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014Complete re-epithelialisation was visualised at endoscopy in 25\/31 patients (81%) after a mean number of 2.4 APC sessions (range 1\u20134). Only partial squamous re-epithelialisation was observed in three patients and three others had no eradication. At histological assessment, eradication of Barrett\u2019s oesophagus was only confirmed in 19\/31 patients (61%) due to the presence of a few residual Barrett\u2019s glands under the new squamous epithelium. Complete eradication was related to a Barrett\u2019s oesophagus segment length of less than 4 cm and the absence of circumferential extension but not to the normalisation of oesophageal acid exposure under PPI therapy. Seventeen patients with apparently complete endoscopic and histological eradication of Barrett\u2019s oesophagus were re-evaluated at one year; eight (47%) disclosed relapsing islands of Barrett metaplasia despite continuous omeprazole therapy (10\u201340 mg\/day).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    \u2014APC combined with 40 mg omeprazole daily can eradicate Barrett\u2019s mucosa with apparent squamous re-epithelialisation in the majority of patients even in the absence of normalisation of oesophageal acid exposure. However, one year after endotherapy for Barrett\u2019s oesophagus, relapse is frequent but limited in extent.\n                  <\/jats:p>","DOI":"10.1136\/gut.43.6.747","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"747-751","source":"Crossref","is-referenced-by-count":160,"title":["Eradication of Barrett\u2019s mucosa with argon plasma coagulation and acid suppression: immediate and mid term results"],"prefix":"10.1136","volume":"43","author":[{"given":"J-L","family":"Van Laethem","sequence":"first","affiliation":[{"name":"aDepartment of Gastroenterology, Erasme University Hospital, Brussels, Belgium, \n\nbDepartment of Pathology, Erasme University Hospital, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Cremer","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology, Erasme University Hospital, Brussels, Belgium, 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