{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T21:34:30Z","timestamp":1765661670072,"version":"3.48.0"},"reference-count":37,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1998,6,4]]},"published-print":{"date-parts":[[1998,12,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    \u2014Chronic diarrhoea is the clinical hallmark of patients presenting with idiopathic bile acid malabsorption. Its pathogenesis is unknown; colonic water secretion can be induced by dihydroxy bile acids, but it is not known whether enrichment of the bile acid pool with these bile acids occurs in such patients. Furthermore, bile acid malabsorption is known to affect biliary lipid composition, but no information is available for the idiopathic type.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Aims<\/jats:italic>\n                    \u2014To verify: (\n                    <jats:italic>a<\/jats:italic>\n                    ) whether diarrhoea in patients with idiopathic bile acid malabsorption is associated with enrichment of the bile acid pool with dihydroxy bile acids; and (\n                    <jats:italic>b<\/jats:italic>\n                    ) whether supersaturation with cholesterol of duodenal bile occurs in such patients as a result of chronic bile acid depletion.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Patients<\/jats:italic>\n                    \u2014Thirteen patients with idiopathic bile acid malabsorption diagnosed according to abnormal\n                    <jats:sup>75<\/jats:sup>\n                    SeHCAT test and absence of other organic diseases, and 23 control subjects.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Methods<\/jats:italic>\n                    \u2014Bile rich duodenal fluid was collected during intravenous ceruletide infusion in the fasting state. Biliary lipids were analysed by enzymatic assays and bile acids by high performance liquid chromatography.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results<\/jats:italic>\n                    \u2014Patients with idiopathic bile acid malabsorption had a cholesterol saturation index similar to controls. Bile acid composition showed only a decrease in percentage cholic acid (29 (2)% versus 36 (2)%; p&lt;0.05); the dihydroxy:trihydroxy bile acid ratio was similar to controls.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions<\/jats:italic>\n                    \u2014Patients with idiopathic bile acid malabsorption do not have an increased risk of forming cholesterol gallstones. The mechanism of diarrhoea does not seem to depend on an enrichment of the bile acid pool with dihydroxy bile acids.\n                  <\/jats:p>","DOI":"10.1136\/gut.43.6.812","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"812-816","source":"Crossref","is-referenced-by-count":10,"title":["Biliary lipid composition in idiopathic bile acid malabsorption"],"prefix":"10.1136","volume":"43","author":[{"given":"M","family":"Fracchia","sequence":"first","affiliation":[{"name":"aGastroenterology Unit, \n\nbCentral Laboratory, Ospedale Mauriziano Umberto I, Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Pellegrino","sequence":"additional","affiliation":[{"name":"aGastroenterology Unit, \n\nbCentral Laboratory, Ospedale Mauriziano Umberto I, Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Secreto","sequence":"additional","affiliation":[{"name":"aGastroenterology Unit, \n\nbCentral Laboratory, Ospedale Mauriziano Umberto I, Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Pera","sequence":"additional","affiliation":[{"name":"aGastroenterology Unit, \n\nbCentral Laboratory, Ospedale Mauriziano Umberto I, Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Galatola","sequence":"additional","affiliation":[{"name":"aGastroenterology Unit, \n\nbCentral Laboratory, Ospedale Mauriziano Umberto I, Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1998,12,1]]},"reference":[{"key":"2025121313300199000_43.6.812.1","first-page":"174","article-title":"Diarrhoea associated with idiopathic bile acid malabsorption: fact or fantasy?","volume":"20","author":"Hess Thaysen","year":"1973","journal-title":"Danish Med Bull"},{"key":"2025121313300199000_43.6.812.2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0016-5085(83)80167-X","article-title":"Evaluation of ileal function using 23-selena-25-homotaurocholate, a \u03b3-labeled conjugated bile acid. Initial clinical assessment.","volume":"84","author":"Nyhlin","year":"1983","journal-title":"Gastroenterology"},{"key":"2025121313300199000_43.6.812.3","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/0016-5085(86)90377-X","article-title":"Use of a gamma labelled bile acid (75-SeHCAT) as a test of ileal function. Methods of improving accuracy.","volume":"90","author":"Ferraris","year":"1986","journal-title":"Gastroenterology"},{"key":"2025121313300199000_43.6.812.4","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/0016-5085(91)90288-V","article-title":"Direct measurement of first-pass ileal clearance of a bile acid in humans.","volume":"100","author":"Galatola","year":"1991","journal-title":"Gastroenterology"},{"key":"2025121313300199000_43.6.812.5","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.290.6469.665"},{"key":"2025121313300199000_43.6.812.6","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.9.1004"},{"key":"2025121313300199000_43.6.812.7","first-page":"533","article-title":"The prevalence of bile acid malabsorption in irritable bowel syndrome and the effect of cholestyramine: an uncontrolled open multicenter study.","volume":"4","year":"1992","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2025121313300199000_43.6.812.8","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1016\/0016-5085(87)90615-9","article-title":"Primary bile acid malabsorption.","volume":"92","author":"Popovic","year":"1987","journal-title":"Gastroenterology"},{"key":"2025121313300199000_43.6.812.9","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/S0016-5085(82)80009-7","article-title":"Primary bile acid malabsorption: defective in vitro ileal active bile acid transport.","volume":"83","author":"Heubi","year":"1982","journal-title":"Gastroenterology"},{"key":"2025121313300199000_43.6.812.10","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.5.500"},{"key":"2025121313300199000_43.6.812.11","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119355"},{"key":"2025121313300199000_43.6.812.12","doi-asserted-by":"crossref","unstructured":"van Tilburg AJP, de Rooij FWM, van den Berg JWO, et al. Primary bile acid malabsorption: a pathophysiologic and clinical entity? Scand J Gastroenterol1992;27(suppl 194):66\u201370. .","DOI":"10.3109\/00365529209096030"},{"key":"2025121313300199000_43.6.812.13","doi-asserted-by":"publisher","DOI":"10.1136\/gut.13.6.415"},{"key":"2025121313300199000_43.6.812.14","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1007\/BF01296371","article-title":"Effect of partial ileocolectomy and Crohn\u2019s disease on biliary lipid secretion.","volume":"32","author":"Rutgeerts","year":"1987","journal-title":"Dig Dis Sci"},{"key":"2025121313300199000_43.6.812.15","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/0016-5085(92)90858-V","article-title":"Ileal resection\/dysfunction in childhood predisposes to lithogenic bile only after puberty.","volume":"103","author":"Heubi","year":"1992","journal-title":"Gastroenterology"},{"key":"2025121313300199000_43.6.812.16","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/BF01308176","article-title":"Measurement of bile acid half-life using 75SeHCAT in health and intestinal diseases. Comparison with 75SeHCAT abdominal retention methods.","volume":"37","author":"Ferraris","year":"1992","journal-title":"Dig Dis Sci"},{"key":"2025121313300199000_43.6.812.17","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/9780470110249.ch3","article-title":"Enzymatic analysis of steroid hormones.","volume":"8","author":"Talalay","year":"1960","journal-title":"Methods Biochem Anal"},{"key":"2025121313300199000_43.6.812.18","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(75)90364-2"},{"key":"2025121313300199000_43.6.812.19","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(80)90123-0"},{"key":"2025121313300199000_43.6.812.20","first-page":"176S","article-title":"Bile sampling, processing and analysis in clinical studies.","volume":"12","author":"Strasberg","year":"1990","journal-title":"Hepatology"},{"key":"2025121313300199000_43.6.812.21","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/S0016-5085(19)33056-2","article-title":"A simple calculation of the lithogenic index of bile expressing biliary lipid composition on rectangular coordinates.","volume":"65","author":"Thomas","year":"1973","journal-title":"Gastroenterology"},{"key":"2025121313300199000_43.6.812.22","doi-asserted-by":"publisher","DOI":"10.1007\/BF02020933"},{"key":"2025121313300199000_43.6.812.23","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)86390-6"},{"key":"2025121313300199000_43.6.812.24","first-page":"18","article-title":"Biliary cholesterol and lithogeneity of bile in patients after ileal resection.","volume":"104","author":"F\u00e4rkkil\u00e4","year":"1988","journal-title":"Surgery"},{"key":"2025121313300199000_43.6.812.25","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.12.1488"},{"key":"2025121313300199000_43.6.812.26","unstructured":"Koivisto P, Miettilnen TA. Gallbladder disease, bile composition and bile acid absorption after ileal bypass.Hepatogastroenterology 1990;37(suppl 2):49\u201354. ."},{"key":"2025121313300199000_43.6.812.27","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/j.1365-2362.1995.tb01741.x","article-title":"Effect of colectomy with ileo-anal anastomosis on the biliary lipids","volume":"25","author":"Galatola","year":"1995","journal-title":"Eur J Clin Invest"},{"key":"2025121313300199000_43.6.812.28","first-page":"641","article-title":"Idiopathic bile acid malabsorption: long-term outcome.","volume":"7","author":"Luman","year":"1995","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2025121313300199000_43.6.812.29","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(87)90045-3"},{"key":"2025121313300199000_43.6.812.30","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90846-5"},{"key":"2025121313300199000_43.6.812.31","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1159\/000199608","article-title":"Fecal and biliary bile acid composition after partial ileal bypass operation.","volume":"39","author":"Koivisto","year":"1988","journal-title":"Digestion"},{"key":"2025121313300199000_43.6.812.32","doi-asserted-by":"publisher","DOI":"10.1136\/gut.20.12.1078"},{"key":"2025121313300199000_43.6.812.33","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0016-5085(73)80101-5","article-title":"Disappearance of deoxycholic acid after ileal resection.","volume":"64","author":"Kern","year":"1973","journal-title":"Gastroenterology"},{"key":"2025121313300199000_43.6.812.34","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0016-5085(73)80088-5","article-title":"Patterns of bile acids and microflora in the human small intestine. I. Bile acids.","volume":"64","author":"Mallory","year":"1973","journal-title":"Gastroenterology"},{"key":"2025121313300199000_43.6.812.35","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(96)70024-0"},{"key":"2025121313300199000_43.6.812.36","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90556-8"},{"key":"2025121313300199000_43.6.812.37","doi-asserted-by":"publisher","DOI":"10.1136\/gut.27.5.550"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.43.6.812","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T21:30:09Z","timestamp":1765661409000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.43.6.812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,12,1]]},"references-count":37,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1998,12,1]]},"published-print":{"date-parts":[[1998,12,1]]}},"alternative-id":["10.1136\/gut.43.6.812"],"URL":"https:\/\/doi.org\/10.1136\/gut.43.6.812","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1998,12,1]]}}}