{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T16:25:44Z","timestamp":1765643144180,"version":"3.48.0"},"reference-count":27,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1998,9,23]]},"published-print":{"date-parts":[[1999,3,1]]},"abstract":"<jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>In normal subjects, transient lower oesophageal sphincter relaxations (TLOSRs) and gas reflux during belching are suppressed in the supine position. Supine reflux, however, is a feature of reflux disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>AIMS<\/jats:title>\n                    <jats:p>To investigate whether postural suppression of TLOSRs and gas reflux is impaired in patients with reflux disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PATIENTS<\/jats:title>\n                    <jats:p>Ten patients with erosive oesophagitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"methods\">\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Oesophageal manometry was performed during gastric distension with 750 ml carbon dioxide. Measurements were made for 10 minutes before and after distension in both sitting and supine positions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>In the sitting position gastric distension substantially increased the rate of gas reflux (median (interquartile range)), as evidenced by increases in oesophageal common cavities from 1 (0\u20131)\/10 min to 7 (5\u201310)\/10 min and TLOSRs from 1 (1\u20131.5)\/10 min to 6 (2.5\u20138)\/10 min. However, this effect was suppressed in the supine position in all but one patient (TLOSRs 0 (0)\/10 min to 1 (0\u20134.5)\/10 min, common cavities 0 (0)\/10 min to 0.5 (0\u20132)\/10 min).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Postural suppression of TLOSRs and gas reflux is generally preserved in reflux disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gut.44.3.313","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"313-316","source":"Crossref","is-referenced-by-count":17,"title":["Preservation of postural control of transient lower oesophageal sphincter relaxations in patients with reflux oesophagitis"],"prefix":"10.1136","volume":"44","author":[{"given":"A C","family":"Ireland","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Medicine, Royal Adelaide Hospital, Adelaide, SA 5000, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Dent","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Medicine, Royal Adelaide Hospital, Adelaide, SA 5000, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R H","family":"Holloway","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Medicine, Royal Adelaide Hospital, Adelaide, SA 5000, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1999,3,1]]},"reference":[{"key":"2025121308213349000_44.3.313.1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.29.8.1020"},{"key":"2025121308213349000_44.3.313.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198212163072503"},{"key":"2025121308213349000_44.3.313.3","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90011-X"},{"key":"2025121308213349000_44.3.313.4","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1365-2982.1996.tb00253.x","article-title":"Motor events underlying gastro-oesophageal reflux in ambulant patients with reflux oesophagitis.","volume":"8","author":"Penagini","year":"1996","journal-title":"Journal of Neurogastroenterology and Motility"},{"key":"2025121308213349000_44.3.313.5","doi-asserted-by":"publisher","DOI":"10.1136\/gut.31.6.639"},{"key":"2025121308213349000_44.3.313.6","doi-asserted-by":"publisher","DOI":"10.1136\/gut.30.6.762"},{"key":"2025121308213349000_44.3.313.7","doi-asserted-by":"publisher","DOI":"10.1136\/gut.28.5.519"},{"key":"2025121308213349000_44.3.313.8","doi-asserted-by":"publisher","DOI":"10.1136\/gut.28.11.1484"},{"key":"2025121308213349000_44.3.313.9","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0016-5085(87)90318-0","article-title":"Optimal thresholds, sensitivity, and specificity of long-term pH-metry for the detection of gastroesophageal reflux disease.","volume":"93","author":"Schindlbeck","year":"1987","journal-title":"Gastroenterology"},{"key":"2025121308213349000_44.3.313.10","first-page":"629","article-title":"Ambulatory esophageal pH recording in gastroesophageal reflux: relevance to the development of esophagitis.","volume":"83","author":"Rokkas","year":"1988","journal-title":"Am J Gastroenterol"},{"key":"2025121308213349000_44.3.313.11","first-page":"36","article-title":"Acid reflux and oesophagitis-day or night?","volume":"1","author":"Jenkinson","year":"1990","journal-title":"Gullet"},{"key":"2025121308213349000_44.3.313.12","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/00365521.1990.12067095","article-title":"Ambulatory 24 hour pH-metry in the diagnosis of gastroesophageal reflux disease. 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