{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T23:01:23Z","timestamp":1765666883914,"version":"3.48.0"},"reference-count":44,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1998,12,1]]},"published-print":{"date-parts":[[1999,5,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Treatment of acromegaly with octreotide increases the proportion of deoxycholic acid in, and the cholesterol saturation of, bile and induces the formation of gallstones. Prolongation of intestinal transit has been proposed as the mechanism for the increase in the proportion of deoxycholic acid in bile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>AIMS<\/jats:title>\n                    <jats:p>To study the effects of octreotide on intestinal transit in acromegalic patients during octreotide treatment, and to examine the relation between intestinal transit and bile acid composition in fasting serum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"methods\">\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Mouth to caecum and large bowel transit times, and the proportion of deoxycholic acid in fasting serum were measured in non-acromegalic controls, acromegalic patients untreated with octreotide, acromegalics on long term octreotide, and patients with simple constipation. Intestinal transit and the proportion of deoxycholic acid were compared in acromegalic patients before and during octreotide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Acromegalics untreated with octreotide had longer mouth to caecum and large bowel transit times than controls. Intestinal transit was further prolonged by chronic octreotide treatment. There were significant linear relations between large bowel transit time and the proportion of deoxycholic acid in the total, conjugated, and unconjugated fractions of fasting serum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>These data support the hypothesis that, by prolonging large bowel transit, octreotide increases the proportion of deoxycholic acid in fasting serum (and, by implication, in bile) and thereby the risk of gallstone formation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gut.44.5.675","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"675-681","source":"Crossref","is-referenced-by-count":59,"title":["Prolonged large bowel transit increases serum deoxycholic acid: a risk factor for octreotide induced gallstones"],"prefix":"10.1136","volume":"44","author":[{"given":"M J","family":"Veysey","sequence":"first","affiliation":[{"name":"aGastroenterology Unit, 5th floor, Thomas Guy House, Guy\u2019s Hospital, London SE1 9RT, UK, \n\nbMass Spectrometry Laboratory, St Thomas\u2019s Hospital Campus, UMDS, London, UK, \n\ncDepartment of Endocrinology, St Bartholomew\u2019s Hospital, London, UK, \n\ndThe Radcliffe Infirmary, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L A","family":"Thomas","sequence":"additional","affiliation":[{"name":"aGastroenterology Unit, 5th floor, Thomas Guy House, Guy\u2019s Hospital, London SE1 9RT, UK, \n\nbMass Spectrometry Laboratory, St Thomas\u2019s Hospital Campus, UMDS, London, UK, \n\ncDepartment of Endocrinology, St Bartholomew\u2019s Hospital, London, UK, \n\ndThe Radcliffe Infirmary, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A I","family":"Mallet","sequence":"additional","affiliation":[{"name":"aGastroenterology Unit, 5th floor, Thomas Guy House, Guy\u2019s Hospital, London SE1 9RT, UK, \n\nbMass Spectrometry Laboratory, St Thomas\u2019s Hospital Campus, UMDS, London, UK, \n\ncDepartment of Endocrinology, St Bartholomew\u2019s Hospital, London, UK, \n\ndThe Radcliffe Infirmary, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P J","family":"Jenkins","sequence":"additional","affiliation":[{"name":"aGastroenterology Unit, 5th floor, Thomas Guy House, Guy\u2019s Hospital, London SE1 9RT, UK, \n\nbMass Spectrometry Laboratory, St Thomas\u2019s Hospital Campus, UMDS, London, UK, \n\ncDepartment of Endocrinology, St Bartholomew\u2019s Hospital, London, UK, \n\ndThe Radcliffe Infirmary, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G M","family":"Besser","sequence":"additional","affiliation":[{"name":"aGastroenterology Unit, 5th floor, Thomas Guy House, Guy\u2019s Hospital, London SE1 9RT, UK, \n\nbMass Spectrometry Laboratory, St Thomas\u2019s Hospital Campus, UMDS, London, UK, \n\ncDepartment of Endocrinology, St Bartholomew\u2019s Hospital, London, UK, \n\ndThe Radcliffe Infirmary, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A H","family":"Wass","sequence":"additional","affiliation":[{"name":"aGastroenterology Unit, 5th floor, Thomas Guy House, Guy\u2019s Hospital, London SE1 9RT, UK, \n\nbMass Spectrometry Laboratory, St Thomas\u2019s Hospital Campus, UMDS, London, UK, \n\ncDepartment of Endocrinology, St Bartholomew\u2019s Hospital, London, UK, \n\ndThe Radcliffe Infirmary, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G M","family":"Murphy","sequence":"additional","affiliation":[{"name":"aGastroenterology Unit, 5th floor, Thomas Guy House, Guy\u2019s Hospital, London SE1 9RT, UK, \n\nbMass Spectrometry Laboratory, St Thomas\u2019s Hospital Campus, UMDS, London, UK, \n\ncDepartment of Endocrinology, St Bartholomew\u2019s Hospital, London, UK, \n\ndThe Radcliffe Infirmary, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R H","family":"Dowling","sequence":"additional","affiliation":[{"name":"aGastroenterology Unit, 5th floor, Thomas Guy House, Guy\u2019s Hospital, London SE1 9RT, UK, \n\nbMass Spectrometry Laboratory, St Thomas\u2019s Hospital Campus, UMDS, London, UK, \n\ncDepartment of Endocrinology, St Bartholomew\u2019s Hospital, London, UK, \n\ndThe Radcliffe Infirmary, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1999,5,1]]},"reference":[{"key":"2025121219292833000_44.5.675.1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-112-3-173"},{"key":"2025121219292833000_44.5.675.2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.80.9.2768"},{"key":"2025121219292833000_44.5.675.3","first-page":"1042","article-title":"Octreotide-associated biliary tract dysfunction and gallstone formation: pathophysiology and management.","volume":"90","author":"Redfern","year":"1995","journal-title":"Am J Gastroenterol"},{"key":"2025121219292833000_44.5.675.4","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(92)90185-D"},{"key":"2025121219292833000_44.5.675.5","doi-asserted-by":"publisher","DOI":"10.1136\/gut.38.5.775"},{"key":"2025121219292833000_44.5.675.6","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.6.808"},{"key":"2025121219292833000_44.5.675.7","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-69-3-557"},{"key":"2025121219292833000_44.5.675.8","first-page":"295","article-title":"Assessment of gallbladder dynamics, cholecystokinin release and the development of gallstones during octreotide therapy for acromegaly.","volume":"83","author":"Ewins","year":"1992","journal-title":"Q J Med"},{"key":"2025121219292833000_44.5.675.9","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.2.270"},{"key":"2025121219292833000_44.5.675.10","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90556-8"},{"key":"2025121219292833000_44.5.675.11","doi-asserted-by":"publisher","DOI":"10.1136\/gut.29.4.522"},{"key":"2025121219292833000_44.5.675.12","doi-asserted-by":"publisher","DOI":"10.1136\/gut.9.1.22"},{"key":"2025121219292833000_44.5.675.13","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1093\/ajcn\/27.11.1341","article-title":"Microbial bile acid transformation.","volume":"27","author":"Midtvedt","year":"1974","journal-title":"Am J Clin Nutr"},{"key":"2025121219292833000_44.5.675.14","first-page":"1063","article-title":"Absorption of bile acids by the colon [abstract].","volume":"11","author":"Morris","year":"1970","journal-title":"Gut"},{"key":"2025121219292833000_44.5.675.15","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105892"},{"key":"2025121219292833000_44.5.675.16","doi-asserted-by":"publisher","DOI":"10.1136\/gut.27.5.550"},{"key":"2025121219292833000_44.5.675.17","doi-asserted-by":"publisher","DOI":"10.1159\/000048361"},{"key":"2025121219292833000_44.5.675.18","doi-asserted-by":"publisher","DOI":"10.1159\/000199408"},{"key":"2025121219292833000_44.5.675.19","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1042\/cs0750345","article-title":"Effects of somatostatin analogue SMS 201\u2013955 (sandostatin) on mouth-to-caecum transit time and absorption of fat and carbohydrates in normal man.","volume":"750","author":"M\u00f8ller","year":"1988","journal-title":"Clin Sci"},{"key":"2025121219292833000_44.5.675.20","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1365-2036.1990.tb00463.x","article-title":"Effect of octreotide on mouth-to-caecum transit time in healthy subjects and in the irritable bowel syndrome.","volume":"4","author":"O\u2019Donnell","year":"1990","journal-title":"Aliment Pharmacol Ther"},{"key":"2025121219292833000_44.5.675.21","unstructured":"Trainer PJ Besser M (1995) Acromegaly. The Bart\u2019s endocrine protocols. (Churchill Livingstone, London), pp 80\u201381."},{"key":"2025121219292833000_44.5.675.22","first-page":"546","article-title":"Investigation of small bowel transit time in man utilizing pulmonary hydrogen measurements.","volume":"85","author":"Bond","year":"1974","journal-title":"J Lab Clin Med"},{"key":"2025121219292833000_44.5.675.23","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90837-7"},{"key":"2025121219292833000_44.5.675.24","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(82)90190-5"},{"key":"2025121219292833000_44.5.675.25","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(83)90070-0"},{"key":"2025121219292833000_44.5.675.26","unstructured":"Nair PP (1969) Enzymatic cleavage of bile acid conjugates. in Bile salt metabolism. eds Schiff L Carey JB Dietschy J (Charles Thomas Publishers, Springfield, IL), pp 172\u2013183."},{"key":"2025121219292833000_44.5.675.27","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1080\/00032717808067890","article-title":"A novel liquid-gel chromatographic method for extraction of unconjugated steroids from aqueous solutions.","volume":"B11","author":"Dyfverman","year":"1978","journal-title":"Anal Lett"},{"key":"2025121219292833000_44.5.675.28","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)94498-X"},{"key":"2025121219292833000_44.5.675.29","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/S0022-2275(20)38248-1","article-title":"Determination of plasma bile acids by capillary gas-liquid chromatography-electron capture negative chemical ionization mass fragmentography.","volume":"30","author":"Stellaard","year":"1989","journal-title":"J Lipid Res"},{"issue":"suppl","key":"2025121219292833000_44.5.675.30","first-page":"176","article-title":"Bile sampling, processing and analysis in clinical studies.","volume":"12","author":"Strasberg","year":"1990","journal-title":"Hepatology"},{"key":"2025121219292833000_44.5.675.31","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1148\/radiology.178.3.1994414","article-title":"Diagnostic fine needle puncture of the gallbladder with US guidance.","volume":"178","author":"Swobodnik","year":"1991","journal-title":"Radiology"},{"key":"2025121219292833000_44.5.675.32","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-68-807-271"},{"key":"2025121219292833000_44.5.675.33","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/S0022-2275(20)38758-7","article-title":"Determination of deoxycholic acid pool size and input rate using [24-13C] deoxycholic acid and serum sampling.","volume":"27","author":"Stellaard","year":"1986","journal-title":"J Lipid Res"},{"key":"2025121219292833000_44.5.675.34","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/0016-5085(93)90930-B","article-title":"Deoxycholic acid metabolism in patients with adenomas.","volume":"105","author":"Nagengast","year":"1993","journal-title":"Gastroenterology"},{"key":"2025121219292833000_44.5.675.35","first-page":"A525","article-title":"Large bowel transit time influences deoxycholic acid input rate and pool size\u2014risk factors for octreotide-induced gallstones [abstract].","volume":"112","author":"Veysey","year":"1997","journal-title":"Gastroenterology"},{"key":"2025121219292833000_44.5.675.36","doi-asserted-by":"publisher","DOI":"10.1136\/gut.36.5.743"},{"key":"2025121219292833000_44.5.675.37","doi-asserted-by":"publisher","DOI":"10.1016\/0270-9139(95)90050-0"},{"key":"2025121219292833000_44.5.675.38","first-page":"A499","article-title":"Sluggish gallbladder and small bowel motility are associated with cholesterol gallstones [abstract].","volume":"112","author":"Azzaroli","year":"1997","journal-title":"Gastroenterology"},{"key":"2025121219292833000_44.5.675.39","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1155\/1997\/532036","article-title":"Role of intestinal transit in the pathogenesis of cholesterol gallstones.","volume":"11","author":"Dowling","year":"1997","journal-title":"Can J Gastroenterol"},{"key":"2025121219292833000_44.5.675.40","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92479-D"},{"key":"2025121219292833000_44.5.675.41","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(96)70024-0"},{"key":"2025121219292833000_44.5.675.42","first-page":"A2","article-title":"Is cholelithiasis an intestinal disease [abstract]?","volume":"41(suppl 3)","author":"Thomas","year":"1997","journal-title":"Gut"},{"key":"2025121219292833000_44.5.675.43","doi-asserted-by":"publisher","DOI":"10.1136\/gut.38.6.870"},{"key":"2025121219292833000_44.5.675.44","doi-asserted-by":"publisher","DOI":"10.1136\/gut.41.2.245"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.44.5.675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T03:29:42Z","timestamp":1765596582000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.44.5.675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,5,1]]},"references-count":44,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1999,5,1]]},"published-print":{"date-parts":[[1999,5,1]]}},"alternative-id":["10.1136\/gut.44.5.675"],"URL":"https:\/\/doi.org\/10.1136\/gut.44.5.675","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1999,5,1]]}}}