{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:16:19Z","timestamp":1789193779859,"version":"build-2803163510"},"reference-count":32,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1998,12,17]]},"published-print":{"date-parts":[[1999,5,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Perception of, and adaptation of the rectum to, distension probably play an important role in the maintenance of continence, but perception studies in faecal incontinence provide controversial conclusions possibly related to methodological biases. In order to better understand perception disorders, the aim of this study was to analyse anorectal adaptation to rectal isobaric distension in subjects with incontinence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PATIENTS\/METHODS<\/jats:title>\n                    <jats:p>Between June 95 and December 97, 97 consecutive patients (nine men and 88 women, mean (SEM) age 55 (1) years) suffering from incontinence were evaluated and compared with 15 healthy volunteers (four men and 11 women, mean age 48 (3) years). The patients were classified into three groups according to their perception status to rectal isobaric distensions (impaired, 22; normal, 61; enhanced, 14). Anal and rectal adaptations to increasing rectal pressure were analysed using a model of rectal isobaric distension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The four groups did not differ with respect to age, parity, or sex ratio. Magnitude of incontinence, prevalence of pelvic disorders, and sphincter defects were similar in the incontinent groups. When compared with healthy controls, anal pressure and rectal adaptation to distension were decreased in incontinent patients. When compared with incontinent patients with normal perception, patients with enhanced perception experienced similar rectal adaptation but had reduced anal pressure. In contrast, patients with impaired perception showed considerably decreased rectal adaptation but had similar anal pressure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Abnormal sensations during rectal distension are observed in one third of subjects suffering from incontinence. These abnormalities may reflect hyperreactivity or neuropathological damage of the rectal wall.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gut.44.5.687","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"687-692","source":"Crossref","is-referenced-by-count":29,"title":["Perception of and adaptation to rectal isobaric distension in patients with faecal incontinence"],"prefix":"10.1136","volume":"44","author":[{"given":"L","family":"Siproudhis","sequence":"first","affiliation":[{"name":"Gastroenterology and Clinical Pharmacology Units, H\u00f4pital Pontchaillou, 35033 Rennes Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Bellissant","sequence":"additional","affiliation":[{"name":"Gastroenterology and Clinical Pharmacology Units, H\u00f4pital Pontchaillou, 35033 Rennes Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Juguet","sequence":"additional","affiliation":[{"name":"Gastroenterology and Clinical Pharmacology Units, H\u00f4pital Pontchaillou, 35033 Rennes Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Allain","sequence":"additional","affiliation":[{"name":"Gastroenterology and Clinical Pharmacology Units, H\u00f4pital Pontchaillou, 35033 Rennes Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-F","family":"Bretagne","sequence":"additional","affiliation":[{"name":"Gastroenterology and Clinical Pharmacology Units, H\u00f4pital Pontchaillou, 35033 Rennes Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Gosselin","sequence":"additional","affiliation":[{"name":"Gastroenterology and Clinical Pharmacology Units, H\u00f4pital Pontchaillou, 35033 Rennes Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1999,5,1]]},"reference":[{"key":"2025121302053105000_44.5.687.1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.31.9.1056"},{"key":"2025121302053105000_44.5.687.2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.2.215"},{"key":"2025121302053105000_44.5.687.3","doi-asserted-by":"publisher","DOI":"10.1007\/BF01536422"},{"key":"2025121302053105000_44.5.687.4","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1007\/BF02150743","article-title":"Sensory and motor function in the maintenance of anal incontinence.","volume":"33","author":"Bielefeldt","year":"1990","journal-title":"Dis Colon Rectum"},{"key":"2025121302053105000_44.5.687.5","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.6.807"},{"key":"2025121302053105000_44.5.687.6","first-page":"469","article-title":"How useful are manometric tests of anorectal function in the management of defecation disorders?","volume":"92","author":"Rao","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"2025121302053105000_44.5.687.7","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1007\/BF02552274","article-title":"The appreciation of rectal distension in fecal incontinence.","volume":"32","author":"Ferguson","year":"1989","journal-title":"Dis Colon Rectum"},{"key":"2025121302053105000_44.5.687.8","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/BF02053331","article-title":"Anorectal pressure gradient in patients with faecal incontinence.","volume":"35","author":"Rasmussen","year":"1992","journal-title":"Dis Colon Rectum"},{"key":"2025121302053105000_44.5.687.9","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018885028501"},{"key":"2025121302053105000_44.5.687.10","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/BF00496148","article-title":"Rectal compliance:a critical reappraisal.","volume":"5","author":"Madoff","year":"1990","journal-title":"Int J Colorectal Dis"},{"key":"2025121302053105000_44.5.687.11","doi-asserted-by":"publisher","DOI":"10.1136\/gut.30.4.496"},{"key":"2025121302053105000_44.5.687.12","first-page":"T29","article-title":"Incontinence f\u00e9cale. 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