{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:50:05Z","timestamp":1764996605308,"version":"3.46.0"},"reference-count":39,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1999,1,13]]},"published-print":{"date-parts":[[1999,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>There is a lack of suitable models for testing of therapeutic procedures for gastro-oesophageal reflux disease. Endoscopic sewing methods might allow the development of a new less invasive surgical approach to treatment of gastrointestinal disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>AIMS<\/jats:title>\n                    <jats:p>To develop an animal model of gastro-oesophageal reflux for testing the efficacy of a new antireflux procedure, endoscopic gastroplasty, performed at flexible endoscopy without laparotomy or laparoscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"methods\">\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>At endoscopy a pH sensitive radiotelemetry capsule was sewn to the oesophageal wall, 5 cm above the lower oesophageal sphincter, in six large white pigs. Ambulant pH recordings (48\u201396 hours; total 447 hours) were obtained. The median distal oesophageal pH was 6.8 (range 6.4\u20137.3); pH was less than 4 for 9.3% of the time. After one week, endoscopic gastroplasty was performed by placing sutures below the gastro-oesophageal junction, forming a neo-oesophagus of 1\u20132 cm in length. Postoperative manometry and pH recordings (24\u201396 hours; total 344 hours) were carried out.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Following gastroplasty, the median sphincter pressure increased significantly from 3 to 6 mm Hg and in length from 3 to 3.75 cm. The median time pH was less than 4 decreased significantly from 9.3% to 0.2%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>These are the first long term measurements of oesophageal pH in ambulant pigs. The finding of spontaneous reflux suggested a model for studying treatments of reflux. Endoscopic gastroplasty increased sphincter pressure and length and decreased acid reflux.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gut.44.6.782","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"782-788","source":"Crossref","is-referenced-by-count":45,"title":["An ambulant porcine model of acid reflux used to evaluate endoscopic gastroplasty"],"prefix":"10.1136","volume":"44","author":[{"given":"S S","family":"Kadirkamanathan","sequence":"first","affiliation":[{"name":"aGastrointestinal Science Research Unit, The London Hospital Medical College, London, UK, \n\nbDepartment of Medical Physics, University College, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Yazaki","sequence":"additional","affiliation":[{"name":"aGastrointestinal Science Research Unit, The London Hospital Medical College, London, UK, \n\nbDepartment of Medical Physics, University College, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D F","family":"Evans","sequence":"additional","affiliation":[{"name":"aGastrointestinal Science Research Unit, The London Hospital Medical College, London, UK, \n\nbDepartment of Medical Physics, University College, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C C","family":"Hepworth","sequence":"additional","affiliation":[{"name":"aGastrointestinal Science Research Unit, The London Hospital Medical College, London, UK, \n\nbDepartment of Medical Physics, University College, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Gong","sequence":"additional","affiliation":[{"name":"aGastrointestinal Science Research Unit, The London Hospital Medical College, London, UK, \n\nbDepartment of Medical Physics, University College, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C P","family":"Swain","sequence":"additional","affiliation":[{"name":"aGastrointestinal Science Research Unit, The London Hospital Medical College, London, UK, \n\nbDepartment of Medical Physics, University College, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1999,6,1]]},"reference":[{"key":"2025120520362747000_44.6.782.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(86)71727-6"},{"key":"2025120520362747000_44.6.782.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(96)70130-X"},{"key":"2025120520362747000_44.6.782.3","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/S0016-5107(94)70117-2","article-title":"An endoscopically deliverable tissue transfixing device for securing biosensors in the gastrointestinal tract.","volume":"40","author":"Swain","year":"1994","journal-title":"Gastrointest Endosc"},{"key":"2025120520362747000_44.6.782.4","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/S0016-5107(94)70116-4","article-title":"Knot tying at flexible endoscopy.","volume":"40","author":"Swain","year":"1994","journal-title":"Gastrointest Endosc"},{"key":"2025120520362747000_44.6.782.5","first-page":"26","article-title":"New methods of cutting threads at flexible endoscopy [abstract].","volume":"40","author":"Kadirkamanathan","year":"1994","journal-title":"Gastrointest Endosc"},{"key":"2025120520362747000_44.6.782.6","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0016-5085(19)32264-4","article-title":"Improved infusion system for intraesophageal manometry.","volume":"73","author":"Arndofer","year":"1977","journal-title":"Gastroenterology"},{"key":"2025120520362747000_44.6.782.7","first-page":"325","article-title":"Twenty-four hour pH monitoring of the distal esophagus. 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