{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T01:53:36Z","timestamp":1775267616038,"version":"3.50.1"},"reference-count":0,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1999,6,1]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p><jats:italic>Helicobacter pylori<\/jats:italic>, the main cause of chronic gastritis, is a class I gastric carcinogen. Chronic gastritis progresses to cancer through atrophy, metaplasia, and dysplasia. Precancerous phenotypic expression is generally associated with acquired genomic instability.<\/jats:p><\/jats:sec><jats:sec><jats:title>AIM<\/jats:title><jats:p>To evaluate the effect of <jats:italic>H pylori<\/jats:italic> infection and its eradication on gastric histology, cell proliferation, DNA status, and oncogene expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS\/SUBJECTS<\/jats:title><jats:p>Morphometric and immunohistochemical techniques were used to examine gastric mucosal biopsy specimens from eight controls, 10 patients with<jats:italic>H pylori<\/jats:italic> negative chronic gastritis, 53 with<jats:italic>H pylori<\/jats:italic> positive chronic gastritis, and 11 with gastric cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>All patients with chronic gastritis were in a hyperproliferative state related to mucosal inflammation, regardless of <jats:italic>H pylori<\/jats:italic>infection. Atrophy was present in three of 10 patients with<jats:italic>H pylori<\/jats:italic> negative chronic gastritis and in 26 of 53 with <jats:italic>H pylori<\/jats:italic> positive chronic gastritis, associated in 18 with intestinal metaplasia. DNA content was abnormal in only 11 patients with atrophy and <jats:italic>H pylori<\/jats:italic> infection; eight of these also had c-Myc expression, associated in six cases with p53 expression. Fifty three patients with<jats:italic>H pylori<\/jats:italic> positive chronic gastritis were monitored for 12 months after antibiotic treatment: three dropped out; infection was eradicated in 45, in whom cell proliferation decreased in parallel with the reduction in gastritis activity; atrophy previously detected in 21\/45 disappeared in five, regressed from moderate to mild in nine, and remained unchanged in seven; complete metaplasia disappeared in 4\/14, and markers of genomic instability disappeared where previously present. In the five patients in whom<jats:italic>H pylori<\/jats:italic> persisted, atrophy, metaplasia, dysplasia, and markers of genomic instability remained unchanged.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Chronic<jats:italic>H pylori<\/jats:italic> infection seems to be responsible for genomic instability in a subset of cases of <jats:italic>H pylori<\/jats:italic> positive chronic atrophic gastritis; eradication of<jats:italic>H pylori<\/jats:italic> infection can reverse inflammation and the related atrophy, metaplasia, and genomic instability.<\/jats:p><\/jats:sec>","DOI":"10.1136\/gut.44.6.789","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T16:46:12Z","timestamp":1277916372000},"page":"789-799","source":"Crossref","is-referenced-by-count":97,"title":["Effect of <i>Helicobacter pylori<\/i>infection and its eradication on cell proliferation, DNA status, and oncogene expression in patients with chronic gastritis"],"prefix":"10.1136","volume":"44","author":[{"given":"G","family":"Nardone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Staibano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Rocco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Mezza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F P","family":"D\u2019Armiento","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Insabato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Coppola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Salvatore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Lucariello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Figura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"De Rosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Budillon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1999,6,1]]},"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.44.6.789","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T03:35:37Z","timestamp":1601091337000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.44.6.789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1999,6,1]]},"published-print":{"date-parts":[[1999,6,1]]}},"alternative-id":["10.1136\/gut.44.6.789"],"URL":"https:\/\/doi.org\/10.1136\/gut.44.6.789","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,6,1]]}}}