{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T02:17:43Z","timestamp":1764987463840,"version":"3.46.0"},"reference-count":19,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1999,2,2]]},"published-print":{"date-parts":[[1999,7,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Development of gastric mucosa associated lymphoid tissue (MALT) lymphoma is thought to be closely associated with host immune reactions to\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>AIM<\/jats:title>\n                    <jats:p>\n                      To investigate humoral immune responses in patients with MALT lymphoma to antigens shared by\n                      <jats:italic>H pylori<\/jats:italic>\n                      and human gastric epithelial cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"methods\">\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Sera were obtained from\n                      <jats:italic>H pylori<\/jats:italic>\n                      positive patients with MALT lymphoma (n = 11) or other gastroduodenal diseases (peptic ulcer, n = 40; non-ulcer dyspepsia, n = 20) and from\n                      <jats:italic>H pylori<\/jats:italic>\n                      negative healthy control subjects (n = 10). Antibodies to HGC-27 human gastric epithelial cells and human recombinant heat shock protein (Hsp) 60 were examined using an enzyme linked immunosorbent assay (ELISA) and immunoblotting.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Antibody titres to HGC-27 cells were significantly elevated in\n                      <jats:italic>H pylori<\/jats:italic>\n                      positive patients with MALT lymphoma when compared with titres in patients with other gastroduodenal diseases and in healthy subjects. Immunoblotting of sera from patients with MALT lymphoma often detected a band with a molecular mass corresponding to Hsp60, and both ELISA and immunoblotting showed elevated antibody titres to the recombinant human Hsp60. Antigenic similarity between Hsp60 and\n                      <jats:italic>H pylori<\/jats:italic>\n                      HspB was documented by immunoblotting experiments.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      Autoantibodies reactive with host gastric epithelial cells are often increased in MALT lymphoma, and Hsp60 is a major target antigen. Immune responses induced by immunological cross reactivity between\n                      <jats:italic>H pylori<\/jats:italic>\n                      HspB and human Hsp60 in gastric epithelium may be involved in the development of MALT lymphoma.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gut.45.1.20","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"20-23","source":"Crossref","is-referenced-by-count":42,"title":["Antibodies to human gastric epithelial cells and heat shock protein 60 in\n                    <i>Helicobacter pylori<\/i>\n                    positive mucosa associated lymphoid tissue lymphoma"],"prefix":"10.1136","volume":"45","author":[{"given":"Y","family":"Kawahara","sequence":"first","affiliation":[{"name":"aFirst Department of Internal Medicine, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama, Japan, \n\nbDepartment of Bacteriology, \n\ncSecond Department of Pathology, \n\ndDepartment of Microbiology, Jichi Medical School, 3311-1 Minani-kouchi, Tochigi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Yokota","sequence":"additional","affiliation":[{"name":"aFirst Department of Internal Medicine, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama, Japan, \n\nbDepartment of Bacteriology, \n\ncSecond Department of Pathology, \n\ndDepartment of Microbiology, Jichi Medical School, 3311-1 Minani-kouchi, Tochigi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Mizuno","sequence":"additional","affiliation":[{"name":"aFirst Department of Internal Medicine, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama, Japan, \n\nbDepartment of Bacteriology, \n\ncSecond Department of Pathology, \n\ndDepartment of Microbiology, Jichi Medical School, 3311-1 Minani-kouchi, Tochigi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Yunoki","sequence":"additional","affiliation":[{"name":"aFirst Department of Internal Medicine, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama, Japan, \n\nbDepartment of Bacteriology, \n\ncSecond Department of Pathology, \n\ndDepartment of Microbiology, Jichi Medical School, 3311-1 Minani-kouchi, Tochigi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Uesu","sequence":"additional","affiliation":[{"name":"aFirst Department of Internal Medicine, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama, Japan, \n\nbDepartment of Bacteriology, \n\ncSecond Department of Pathology, \n\ndDepartment of Microbiology, Jichi Medical School, 3311-1 Minani-kouchi, Tochigi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Okada","sequence":"additional","affiliation":[{"name":"aFirst Department of Internal Medicine, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama, Japan, \n\nbDepartment of Bacteriology, \n\ncSecond Department of Pathology, \n\ndDepartment of Microbiology, Jichi Medical School, 3311-1 Minani-kouchi, Tochigi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"aFirst Department of Internal Medicine, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama, Japan, \n\nbDepartment of Bacteriology, \n\ncSecond Department of Pathology, \n\ndDepartment of Microbiology, Jichi Medical School, 3311-1 Minani-kouchi, Tochigi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Hirai","sequence":"additional","affiliation":[{"name":"aFirst Department of Internal Medicine, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama, Japan, \n\nbDepartment of Bacteriology, \n\ncSecond Department of Pathology, \n\ndDepartment of Microbiology, Jichi Medical School, 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