{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T17:36:39Z","timestamp":1771263399247,"version":"3.50.1"},"reference-count":43,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1999,2,2]]},"published-print":{"date-parts":[[1999,7,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND\/AIMS<\/jats:title>\n                    <jats:p>\n                      Common variable immunodeficiency (CVID) is an immunological disorder characterised by defective antibody production. Patients with CVID have a high risk of gastric cancer. It has been suggested that gastric cancer results from an interaction between environmental factors and a genetic predisposition. The role of\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      as an environmental factor in gastric carcinogenesis is of current interest. Moreover, p53 gene mutations have been reported in gastric cancer. This study focuses on the gastric pathology of patients with CVID and correlation with\n                      <jats:italic>H pylori<\/jats:italic>\n                      infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"methods\">\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Thirty four consecutive dyspeptic patients with CVID (mean age 49.6 years, range 14\u201372; 17 men) were included in the study. An upper gastrointestinal endoscopy was performed and biopsy specimens were taken from the antrum, incisura angularis, and gastric body. Biopsies were used for histological assessment, to identify the presence of\n                      <jats:italic>H pylori,<\/jats:italic>\n                      and to evaluate p53 overexpression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      <jats:italic>H pylori<\/jats:italic>\n                      infection was detected in 14\/34 (41%) patients. Chronic active gastritis involving both antrum and body was observed more frequently in\n                      <jats:italic>H pylori<\/jats:italic>\n                      positive (79%) than\n                      <jats:italic>H pylori<\/jats:italic>\n                      negative (20%) patients (p = 0.001). Similarly, a histological feature of multifocal atrophic gastritis was found more frequently in infected (50%) than uninfected patients (10%) (p = 0.012). In addition, one case of gastric adenocarcinoma and another of notable dysplasia were observed in the\n                      <jats:italic>H pylori<\/jats:italic>\n                      positive group. Overexpression of p53 was found in six (18%) patients, including one with normal gastric mucosa.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      It can be hypothesised that both\n                      <jats:italic>H pylori<\/jats:italic>\n                      and p53 alterations play a role in the gastric carcinogenesis of patients with CVID.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gut.45.1.77","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"77-81","source":"Crossref","is-referenced-by-count":106,"title":["Gastric pathology in patients with common variable immunodeficiency"],"prefix":"10.1136","volume":"45","author":[{"given":"A","family":"Zullo","sequence":"first","affiliation":[{"name":"aDepartment of Clinical Medicine, Gastroenterology, \u201cLa Sapienza\u201d University, Rome, Italy, \n\nbDepartment of Clinical Medicine, Immunology, \n\ncDepartment of Experimental Medicine and Pathology, \n\ndNational Cancer Institute of Genova, Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Romiti","sequence":"additional","affiliation":[{"name":"aDepartment of Clinical Medicine, Gastroenterology, \u201cLa Sapienza\u201d University, Rome, Italy, \n\nbDepartment of Clinical Medicine, Immunology, \n\ncDepartment of Experimental Medicine and Pathology, \n\ndNational Cancer Institute of Genova, Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"aDepartment of Clinical Medicine, Gastroenterology, \u201cLa Sapienza\u201d University, Rome, Italy, \n\nbDepartment of Clinical Medicine, Immunology, \n\ncDepartment of Experimental Medicine and Pathology, \n\ndNational Cancer Institute of Genova, Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Vecchione","sequence":"additional","affiliation":[{"name":"aDepartment of Clinical Medicine, Gastroenterology, \u201cLa Sapienza\u201d University, Rome, Italy, \n\nbDepartment of Clinical Medicine, Immunology, \n\ncDepartment of Experimental Medicine and Pathology, \n\ndNational Cancer Institute of Genova, Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Tomao","sequence":"additional","affiliation":[{"name":"aDepartment of Clinical Medicine, Gastroenterology, \u201cLa Sapienza\u201d University, Rome, Italy, \n\nbDepartment of Clinical Medicine, Immunology, \n\ncDepartment of Experimental Medicine and Pathology, \n\ndNational Cancer Institute of Genova, Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Aiuti","sequence":"additional","affiliation":[{"name":"aDepartment of Clinical Medicine, Gastroenterology, \u201cLa Sapienza\u201d University, Rome, Italy, \n\nbDepartment of Clinical Medicine, Immunology, \n\ncDepartment of Experimental Medicine and Pathology, \n\ndNational Cancer Institute of Genova, Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Frati","sequence":"additional","affiliation":[{"name":"aDepartment of Clinical Medicine, Gastroenterology, \u201cLa Sapienza\u201d University, Rome, Italy, \n\nbDepartment of Clinical Medicine, Immunology, \n\ncDepartment of Experimental Medicine and Pathology, \n\ndNational Cancer Institute of Genova, Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Luzi","sequence":"additional","affiliation":[{"name":"aDepartment of Clinical Medicine, Gastroenterology, \u201cLa Sapienza\u201d University, Rome, Italy, \n\nbDepartment of Clinical Medicine, Immunology, \n\ncDepartment of Experimental Medicine and Pathology, \n\ndNational Cancer Institute of Genova, Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1999,7,1]]},"reference":[{"key":"2025121305131162000_45.1.77.1","first-page":"173","article-title":"Report of a WHO sponsored meeting. 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