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Using such techniques, researchers have reported a wide range of alterations in sensory and in motor function in the FGID. Importantly, however, relationships between such dysfunction and symptoms have been relatively weak, and so the clinical relevance of the former remains unclear. Moreover, the proportions of patients in the various symptom subgroups who display dysfunction, and the extent and severity of their symptoms, require better characterization. On a positive note, progress is occurring on several fronts, especially in relation to functional dyspepsia and irritable bowel syndrome, and based on the data gathered to date, a number of areas where further advances are required can be highlighted.<\/jats:p>","DOI":"10.1136\/gut.45.2008.ii17","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"II17-II24","source":"Crossref","is-referenced-by-count":66,"title":["Principles of applied neurogastroenterology: physiology\/motility\u2013sensation"],"prefix":"10.1136","volume":"45","author":[{"given":"J E","family":"Kellow","sequence":"first","affiliation":[{"name":"aChair, Committee on Physiology: Motility\/Sensation, Multinational Working Teams to Develop Diagnostic Criteria for Functional Gastrointestinal Disorders (Rome II),  Departments of Medicine and Gastroenterology, Royal North Shore Hospital,  University of Sydney,  Sydney, Australia, \n\nbCo-Chair, 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