{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:41:19Z","timestamp":1783485679327,"version":"3.55.0"},"reference-count":29,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1999,3,30]]},"published-print":{"date-parts":[[1999,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Recent data have suggested that cardia biopsy specimens may be more reflective of gastro-oesophageal reflux disease (GORD) than squamous biopsy specimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>AIMS<\/jats:title>\n                    <jats:p>To assess the distribution, severity, and types of mucosal injury in GORD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PATIENTS<\/jats:title>\n                    <jats:p>Thirty patients with symptomatic GORD with no or minimal erosions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"methods\">\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Biopsies were performed at the squamocolumnar junction (Z-line) and 1\u20132 cm below the Z-line. Injury to the columnar mucosa was scored for inflammatory cells, epithelial cell abnormalities, and for the presence of intestinal metaplasia and\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      . A carditis score above 2 was considered positive (maximum score = 9).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Mean carditis scores and percentages of patients with a positive carditis score were higher in Z-line biopsy specimens containing both squamous and columnar mucosa than in those with just columnar mucosa or in specimens taken 1\u20132 cm below the Z-line. Carditis at the Z-line was focal in 49% of the specimens and was always present adjacent to the squamous epithelium. Goblet cells were present more frequently in the specimens immediately at the Z-line than in those 1\u20132 cm below the Z-line.\n                      <jats:italic>H pylori<\/jats:italic>\n                      was present in only four patients. The mean carditis scores of specimens 1\u20132 cm below the Z-line in these patients was significantly higher than in those patients without\n                      <jats:italic>H pylori<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Mucosal injury at the gastric cardia is highly localised to the region adjacent to the squamocolumnar junction in patients with GORD. Morphological studies of the cardia in GORD should focus on tissue samples that contain both squamous and columnar epithelium in order to obtain an accurate picture of the spectrum of injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gut.45.4.484","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"484-488","source":"Crossref","is-referenced-by-count":50,"title":["Inflammation of the gastro-oesophageal junction (carditis) in patients with symptomatic gastro-oesophageal reflux disease: a prospective study"],"prefix":"10.1136","volume":"45","author":[{"given":"T","family":"Lembo","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Digestive Diseases and Gastroenterology, UCLA Medical Centre and Beth Israel Deaconess Medical Centre, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A F","family":"Ippoliti","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Digestive Diseases and Gastroenterology, UCLA Medical Centre and Beth Israel Deaconess Medical Centre, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Ramers","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Digestive Diseases and Gastroenterology, UCLA Medical Centre and Beth Israel Deaconess Medical Centre, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W M","family":"Weinstein","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Digestive Diseases and Gastroenterology, UCLA Medical Centre and Beth Israel Deaconess Medical Centre, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1999,10,1]]},"reference":[{"key":"2025121311514616000_45.4.484.1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1136\/gut.39.2.151","article-title":"Diagnostic value of histology in non-erosive gastro-oesophageal reflux disease.","volume":"39","author":"Schindlbeck","year":"1996","journal-title":"Gut"},{"key":"2025121311514616000_45.4.484.2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0016-5085(75)80046-1","article-title":"The normal human esophageal mucosa: a histological reappraisal.","volume":"68","author":"Weinstein","year":"1975","journal-title":"Gastroenterology"},{"key":"2025121311514616000_45.4.484.3","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198412000-00009"},{"key":"2025121311514616000_45.4.484.4","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/00365521.1990.12067095","article-title":"Ambulatory 24-hour pH-metry in the diagnosis of gastroesophageal reflux disease. 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