{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:47:06Z","timestamp":1790369226050,"version":"4.1.0"},"reference-count":30,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1999,4,27]]},"published-print":{"date-parts":[[1999,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Barrett\u2019s oesophagus, columnar metaplasia of the epithelium, is a premalignant condition with a 50\u2013100-fold increased risk of cancer. The condition is caused by chronic gastro-oesophageal reflux. Regression of metaplasia may decrease the cancer risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>AIMS<\/jats:title>\n                    <jats:p>To determine whether elimination of acid gastro-oesophageal reflux induces a regression of metaplastic epithelium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"methods\">\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Sixty eight patients with acid reflux and proven Barrett\u2019s oesophagus were included in a prospective, randomised, double blind study with parallel groups, and were treated with profound acid secretion suppression with omeprazole 40 mg twice daily, or with mild acid secretion suppression with ranitidine 150 mg twice daily, for 24 months. Endoscopy was performed at 0, 3, 9, 15, and 24 months with measurement of length and surface area of Barrett\u2019s oesophagus; pH-metry was performed at 0 and 3 months. Per protocol analysis was performed on 26 patients treated with omeprazole, and 27 patients treated with ranitidine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Omeprazole reduced reflux to 0.1%, ranitidine to 9.4% per 24 hours. Symptoms were ameliorated in both groups. There was a small, but statistically significant regression of Barrett\u2019s oesophagus in the omeprazole group, both in length and in area. No change was observed in the ranitidine group. The difference between the regression in the omeprazole and ranitidine group was statistically significant for the area of Barrett\u2019s oesophagus (p=0.02), and showed a trend in the same direction for the length of Barrett\u2019s oesophagus (p=0.06).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Profound suppression of acid secretion, leading to elimination of acid reflux, induces partial regression of Barrett\u2019s oesophagus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gut.45.4.489","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"489-494","source":"Crossref","is-referenced-by-count":219,"title":["Endoscopic regression of Barrett\u2019s oesophagus during omeprazole treatment; a randomised double blind study"],"prefix":"10.1136","volume":"45","author":[{"given":"F T M","family":"Peters","sequence":"first","affiliation":[{"name":"aDepartment of Gastroenterology and Hepatology, University Hospital Groningen, Groningen, The Netherlands, \n\nbDepartment of Endocrinology, University Hospital Groningen, Groningen, The Netherlands, \n\ncDepartment of Gastroenterology and Hepatology, University Hospital Leiden, Leiden, The Netherlands, \n\ndDepartment of Gastroenterology and Hepatology, Free University Hospital Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Ganesh","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology and Hepatology, University Hospital Groningen, Groningen, The Netherlands, \n\nbDepartment of Endocrinology, University Hospital Groningen, Groningen, The Netherlands, \n\ncDepartment of Gastroenterology and Hepatology, University Hospital Leiden, Leiden, The Netherlands, \n\ndDepartment of Gastroenterology and Hepatology, Free University Hospital Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E J","family":"Kuipers","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology and Hepatology, University Hospital Groningen, Groningen, The Netherlands, \n\nbDepartment of Endocrinology, University Hospital Groningen, Groningen, The Netherlands, \n\ncDepartment of Gastroenterology and Hepatology, University Hospital Leiden, Leiden, The Netherlands, \n\ndDepartment of Gastroenterology and Hepatology, Free University Hospital Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W J","family":"Sluiter","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology and Hepatology, University Hospital Groningen, Groningen, The Netherlands, \n\nbDepartment of Endocrinology, University Hospital Groningen, Groningen, The Netherlands, \n\ncDepartment of Gastroenterology and Hepatology, University Hospital Leiden, Leiden, The Netherlands, \n\ndDepartment of Gastroenterology and Hepatology, Free University Hospital Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E C","family":"Klinkenberg-Knol","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology and Hepatology, University Hospital Groningen, Groningen, The Netherlands, \n\nbDepartment of Endocrinology, University Hospital Groningen, Groningen, The Netherlands, \n\ncDepartment of Gastroenterology and Hepatology, University Hospital Leiden, Leiden, The Netherlands, \n\ndDepartment of Gastroenterology and Hepatology, Free University Hospital Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C B H W","family":"Lamers","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology and Hepatology, University Hospital Groningen, Groningen, The Netherlands, \n\nbDepartment of Endocrinology, University Hospital Groningen, Groningen, The Netherlands, \n\ncDepartment of Gastroenterology and Hepatology, University Hospital Leiden, Leiden, The Netherlands, \n\ndDepartment of Gastroenterology and Hepatology, Free University Hospital Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J H","family":"Kleibeuker","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology and Hepatology, University Hospital Groningen, Groningen, The Netherlands, \n\nbDepartment of Endocrinology, University Hospital Groningen, Groningen, The Netherlands, \n\ncDepartment of Gastroenterology and Hepatology, University Hospital Leiden, Leiden, The Netherlands, \n\ndDepartment of Gastroenterology and Hepatology, Free University Hospital Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1999,10,1]]},"reference":[{"key":"2025121300582833000_45.4.489.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197608262950904"},{"key":"2025121300582833000_45.4.489.2","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/0016-5085(84)90090-8","article-title":"Adenocarcinoma and Barrett\u2019s esophagus. An overrated risk?","volume":"87","author":"Spechler","year":"1984","journal-title":"Gastroenterology"},{"key":"2025121300582833000_45.4.489.3","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.9.1155"},{"key":"2025121300582833000_45.4.489.4","first-page":"A75","article-title":"Barrett\u2019s esophagus and risk of adenocarcinoma [abstract].","volume":"102","year":"1992","journal-title":"Gastroenterology"},{"key":"2025121300582833000_45.4.489.5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03530060048032"},{"key":"2025121300582833000_45.4.489.6","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1097\/00008469-199512000-00004","article-title":"Risk factors for Barrett\u2019s oesophagus: a life history approach to behavioural assessment in the distant past.","volume":"4","author":"Ritenbaugh","year":"1995","journal-title":"Eur J Cancer Prev"},{"key":"2025121300582833000_45.4.489.7","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930815)72:4<1155::AID-CNCR2820720404>3.0.CO;2-C"},{"key":"2025121300582833000_45.4.489.8","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1056\/NEJM198906013202218","article-title":"Regression of Barrett\u2019s epithelium with omeprazole.","volume":"320","author":"Devi\u00e8re","year":"1989","journal-title":"N Engl J Med"},{"key":"2025121300582833000_45.4.489.9","first-page":"916","article-title":"Regression der Zylinderepithel-Metaplasie bei Barrett-Oesophagus.","volume":"115","author":"Ottenjann","year":"1990","journal-title":"Dtsch Med Wochenschr"},{"key":"2025121300582833000_45.4.489.10","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1365-2036.1993.tb00143.x","article-title":"Regression of columnar lined (Barrett\u2019s) oesophagus with continuous omeprazole therapy.","volume":"7","author":"Gore","year":"1993","journal-title":"Aliment Pharmacol Ther"},{"key":"2025121300582833000_45.4.489.11","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1365-2036.1995.tb00405.x","article-title":"Long term continuous omeprazole treatment of patients with Barrett\u2019s oesophagus.","volume":"9","author":"Neumann","year":"1995","journal-title":"Aliment Pharmacol Ther"},{"key":"2025121300582833000_45.4.489.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(96)70055-X"},{"key":"2025121300582833000_45.4.489.13","first-page":"A255","article-title":"Effect of omeprazole on Barrett\u2019s epithelium after 3 years of therapy [abstract].","volume":"110","author":"Shaffer","year":"1996","journal-title":"Gastroenterology"},{"key":"2025121300582833000_45.4.489.14","first-page":"A74","article-title":"A randomised trial on the effect of acid suppression on regression of Barrett\u2019s oesophagus [abstract].","volume":"110","author":"Caldwell","year":"1996","journal-title":"Gastroenterology"},{"key":"2025121300582833000_45.4.489.15","first-page":"582","article-title":"Normalization of esophageal pH with high-dose proton pump inhibitor therapy does not result in regression of Barrett\u2019s esophagus.","volume":"92","author":"Sharma","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"2025121300582833000_45.4.489.16","first-page":"1844","article-title":"Effect of up to 3 years of high-dose lansoprazole on Barrett\u2019s esophagus.","volume":"89","author":"Sampliner","year":"1994","journal-title":"Am J Gastroenterol"},{"key":"2025121300582833000_45.4.489.17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00332.x"},{"key":"2025121300582833000_45.4.489.18","first-page":"A294","article-title":"Omeprazole-induced regression of Barrett\u2019s esophagus: a 2 year, randomized, controlled double blind trial.","volume":"110","author":"Weinstein","year":"1996","journal-title":"Gastroenterology"},{"key":"2025121300582833000_45.4.489.19","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90061-6"},{"key":"2025121300582833000_45.4.489.20","first-page":"A174","article-title":"Long-term omeprazole effects on Barrett\u2019s mucosa [abstract].","volume":"110","author":"Le Rhun","year":"1996","journal-title":"Gastroenterology"},{"key":"2025121300582833000_45.4.489.21","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-198707002-00007"},{"key":"2025121300582833000_45.4.489.22","doi-asserted-by":"publisher","DOI":"10.1007\/BF01540426"},{"key":"2025121300582833000_45.4.489.23","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1097\/00042737-199410000-00011","article-title":"Mucosal sensitivity and salivary response to infused acid in patients with columnar-lined oesophagus.","volume":"6","author":"Murphy","year":"1994","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2025121300582833000_45.4.489.24","first-page":"A640","article-title":"Further evidence of altered sensitivity to reflux in patients with Barrett\u2019s esophagus.","volume":"110","author":"Bremner","year":"1996","journal-title":"Gastroenterology"},{"key":"2025121300582833000_45.4.489.25","first-page":"989","article-title":"Successful elimination of reflux symptoms does not insure adequate control of acid reflux in patients with Barrett\u2019s esophagus.","volume":"89","author":"Katzka","year":"1994","journal-title":"Am J Gastroenterol"},{"key":"2025121300582833000_45.4.489.26","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1016\/0016-5085(93)90646-T","article-title":"Restoration of squamous mucosa after ablation of Barrett\u2019s esophageal epithelium.","volume":"104","author":"Berenson","year":"1993","journal-title":"Gastroenterology"},{"key":"2025121300582833000_45.4.489.27","doi-asserted-by":"crossref","first-page":"A208","DOI":"10.1016\/0016-5085(95)23491-8","article-title":"Controlled trial of reversal of Barrett\u2019s esophagus with acid suppression and multi-polar electrocoagulation (MPEC) [abstract].","volume":"108","author":"Sampliner","year":"1995","journal-title":"Gastroenterology"},{"key":"2025121300582833000_45.4.489.28","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)03054-1"},{"key":"2025121300582833000_45.4.489.29","first-page":"1719","article-title":"Photodynamic therapy for Barrett\u2019s esophagus: clinical update.","volume":"91","author":"Overholt","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"2025121300582833000_45.4.489.30","doi-asserted-by":"publisher","DOI":"10.1136\/gut.41.3.281"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.45.4.489","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T08:58:38Z","timestamp":1765616318000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.45.4.489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,10,1]]},"references-count":30,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1999,10,1]]},"published-print":{"date-parts":[[1999,10,1]]}},"alternative-id":["10.1136\/gut.45.4.489"],"URL":"https:\/\/doi.org\/10.1136\/gut.45.4.489","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,10,1]]}}}