{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T20:59:18Z","timestamp":1765659558965,"version":"3.48.0"},"reference-count":19,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1999,3,24]]},"published-print":{"date-parts":[[1999,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Lymphocytic gastritis is characterised by an accumulation of lymphocytes in the surface epithelium of the stomach. Lymphocytic gastritis has been linked to coeliac disease and\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>AIMS<\/jats:title>\n                    <jats:p>\n                      To determine whether\n                      <jats:italic>H pylori<\/jats:italic>\n                      eradication leads to resolution of the lymphocytic infiltrate and clinical improvement in patients with lymphocytic gastritis, and to determine their HLA status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"methods\">\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      The Leeds Dyspepsia Questionnaire (LDQ) was administered to 13 patients with lymphocytic gastritis.\n                      <jats:italic>H pylori<\/jats:italic>\n                      serology,\n                      <jats:sup>13<\/jats:sup>\n                      C urea breath test (UBT), and upper gastrointestinal endoscopy with sampling of the duodenum, antrum, and corpus were done in all cases and the HLA status was determined. Eleven patients had at least one positive test for\n                      <jats:italic>H pylori<\/jats:italic>\n                      . Patients with lymphocytic gastritis and\n                      <jats:italic>H pylori<\/jats:italic>\n                      infection were treated with a one week course of omeprazole, clarithromycin, and metronidazole. Gastric and duodenal intraepithelial lymphocyte (IEL) counts were performed, along with histological assessment of gastric and duodenal biopsies before and after\n                      <jats:italic>H pylori<\/jats:italic>\n                      eradication.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Two months after treatment there was a significant reduction in gastric IEL counts in both antrum and corpus. There was no significant change in duodenal IEL counts before and after eradication. According to the Sydney grading there was significant improvement in corpus inflammation after eradication. The patients histologically\n                      <jats:italic>H pylori<\/jats:italic>\n                      positive before treatment became\n                      <jats:italic>H pylori<\/jats:italic>\n                      negative. Dyspepsia scores also improved significantly after treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      <jats:italic>H pylori<\/jats:italic>\n                      eradication treatment in patients with lymphocytic gastritis causes significant improvement in the gastric IEL infiltrate, corpus inflammation, and dyspeptic symptoms.\n                      <jats:italic>H pylori<\/jats:italic>\n                      serology is frequently positive when histology and UBT are negative. Lymphocytic gastritis may represent a specific immune response to\n                      <jats:italic>H pylori<\/jats:italic>\n                      infection.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gut.45.4.495","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"495-498","source":"Crossref","is-referenced-by-count":51,"title":["Effects of\n                    <i>Helicobacter pylori<\/i>\n                    eradication on the natural history of lymphocytic gastritis"],"prefix":"10.1136","volume":"45","author":[{"given":"M","family":"Hayat","sequence":"first","affiliation":[{"name":"aCentre for Digestive Diseases, The General Infirmary at Leeds, Leeds, UK, \n\nbAcademic Unit of Pathological Sciences, University of Leeds, Leeds, UK, \n\ncCellular and Molecular Immunology Laboratory at St James\u2019s University Hospital NHS Trust, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D S","family":"Arora","sequence":"additional","affiliation":[{"name":"aCentre for Digestive Diseases, The General Infirmary at Leeds, Leeds, UK, \n\nbAcademic Unit of Pathological Sciences, University of Leeds, Leeds, UK, \n\ncCellular and Molecular Immunology Laboratory at St James\u2019s University Hospital NHS Trust, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M F","family":"Dixon","sequence":"additional","affiliation":[{"name":"aCentre for Digestive Diseases, The General Infirmary at Leeds, Leeds, UK, \n\nbAcademic Unit of Pathological Sciences, University of Leeds, Leeds, UK, \n\ncCellular and Molecular Immunology Laboratory at St James\u2019s University Hospital NHS Trust, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Clark","sequence":"additional","affiliation":[{"name":"aCentre for Digestive Diseases, The General Infirmary at Leeds, Leeds, UK, \n\nbAcademic Unit of Pathological Sciences, University of Leeds, Leeds, UK, \n\ncCellular and Molecular Immunology Laboratory at St James\u2019s University Hospital NHS Trust, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"O\u2019Mahony","sequence":"additional","affiliation":[{"name":"aCentre for Digestive Diseases, The General Infirmary at Leeds, Leeds, UK, \n\nbAcademic Unit of Pathological Sciences, University of Leeds, Leeds, UK, \n\ncCellular and Molecular Immunology Laboratory at St James\u2019s University Hospital NHS Trust, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1999,10,1]]},"reference":[{"key":"2025121312542813000_45.4.495.1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711540204"},{"key":"2025121312542813000_45.4.495.2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01297450"},{"key":"2025121312542813000_45.4.495.3","doi-asserted-by":"publisher","DOI":"10.1136\/gut.29.9.1258"},{"key":"2025121312542813000_45.4.495.4","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/0016-5085(90)90819-M","article-title":"Lymphocytic gastritis in patients with celiac sprue or sprue like intestinal disease.","volume":"98","author":"Wolber","year":"1990","journal-title":"Gastroenterology"},{"key":"2025121312542813000_45.4.495.5","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.48.10.939"},{"key":"2025121312542813000_45.4.495.6","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.v16.i3.30"},{"key":"2025121312542813000_45.4.495.7","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1097\/00042737-199311000-00003","article-title":"Flow cytometric analysis of intraepithelial lymphocytes from human small intestinal biopsies reveals populations of CD4+CD8+ and CD80 alpha alpha+ cells.","volume":"5","author":"Lynch","year":"1993","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2025121312542813000_45.4.495.8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1998.00404.x"},{"key":"2025121312542813000_45.4.495.9","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"2025121312542813000_45.4.495.10","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/16.3.1215"},{"key":"2025121312542813000_45.4.495.11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1995.tb03127.x"},{"key":"2025121312542813000_45.4.495.12","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(83)90106-X"},{"key":"2025121312542813000_45.4.495.13","doi-asserted-by":"publisher","DOI":"10.1136\/gut.26.11.1210"},{"key":"2025121312542813000_45.4.495.14","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.48.12.1111"},{"key":"2025121312542813000_45.4.495.15","first-page":"367","article-title":"Lymphocytic gastritis: a clinicopathological study of 32 patients.","volume":"2","author":"Jones","year":"1990","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2025121312542813000_45.4.495.16","first-page":"1663","article-title":"Studies of intestinal lymphoid tissue. XI\u2014The immunopathology of cell-mediated reactions in gluten sensitivity and other enteropathies.","volume":"2","author":"Marsh","year":"1988","journal-title":"Scanning Microsc"},{"key":"2025121312542813000_45.4.495.17","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.4.377"},{"key":"2025121312542813000_45.4.495.18","doi-asserted-by":"publisher","DOI":"10.1136\/gut.31.1.32"},{"key":"2025121312542813000_45.4.495.19","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91819-P"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.45.4.495","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T20:54:35Z","timestamp":1765659275000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.45.4.495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,10,1]]},"references-count":19,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1999,10,1]]},"published-print":{"date-parts":[[1999,10,1]]}},"alternative-id":["10.1136\/gut.45.4.495"],"URL":"https:\/\/doi.org\/10.1136\/gut.45.4.495","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1999,10,1]]}}}