{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:31:58Z","timestamp":1792146718718,"version":"4.4.0"},"reference-count":15,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[1999,3,18]]},"published-print":{"date-parts":[[1999,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Hepatoblastoma is an exceptional cause of primary malignant liver tumour in the adult.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PATIENT<\/jats:title>\n                    <jats:p>The case is reported of an adult patient transplanted for alcoholic cirrhosis complicated by multifocal hepatocellular carcinoma in whom a recurrence in the form of a mixed hepatoblastoma invading the whole transplanted liver developed three months after liver transplantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"methods\">\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Complete clinical, histopathological, and immunohistochemical data were reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The recurrent tumour invaded the whole liver. The major component was a mixed hepatoblastoma, with an epithelial component expressing cytokeratin and a mesenchymal component expressing vimentin. The tumour also contained a minor hepatocarcinomatous component expressing \u03b1 fetoprotein. The rapid growth of the tumour prevented any attempt at treatment. Although direct evidence is lacking, the most likely hypothesis to explain the observations is a marked phenotypic change in the initial malignant population at recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>This case supports a possible filiation between hepatocellular carcinoma and hepatoblastoma in adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gut.45.4.622","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T12:46:12Z","timestamp":1277901972000},"page":"622-625","source":"Crossref","is-referenced-by-count":16,"title":["Recurrence of hepatocellular carcinoma as a mixed hepatoblastoma after liver transplantation"],"prefix":"10.1136","volume":"45","author":[{"given":"J","family":"Dumortier","sequence":"first","affiliation":[{"name":"aUnit\u00e9 d\u2019H\u00e9patologie, H\u00f4tel-Dieu, Lyon, France, \n\nbLaboratoire d\u2019Anatomie Pathologique, Fondation Marcel M\u00e9rieux, Lyon, France, \n\ncD\u00e9partement de Transplantation H\u00e9patique, H\u00f4pital de la Croix-Rousse, Lyon, France, \n\ndLaboratoire Central d\u2019Anatomie et Cytologie Pathologiques, H\u00f4pital Edouard Herriot, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Bizollon","sequence":"additional","affiliation":[{"name":"aUnit\u00e9 d\u2019H\u00e9patologie, H\u00f4tel-Dieu, Lyon, France, \n\nbLaboratoire d\u2019Anatomie Pathologique, Fondation Marcel M\u00e9rieux, Lyon, France, \n\ncD\u00e9partement de Transplantation H\u00e9patique, H\u00f4pital de la Croix-Rousse, Lyon, France, \n\ndLaboratoire Central d\u2019Anatomie et Cytologie Pathologiques, H\u00f4pital Edouard Herriot, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Chevallier","sequence":"additional","affiliation":[{"name":"aUnit\u00e9 d\u2019H\u00e9patologie, H\u00f4tel-Dieu, Lyon, France, \n\nbLaboratoire d\u2019Anatomie Pathologique, Fondation Marcel M\u00e9rieux, Lyon, France, \n\ncD\u00e9partement de Transplantation H\u00e9patique, H\u00f4pital de la Croix-Rousse, Lyon, France, \n\ndLaboratoire Central d\u2019Anatomie et Cytologie Pathologiques, H\u00f4pital Edouard Herriot, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Ducerf","sequence":"additional","affiliation":[{"name":"aUnit\u00e9 d\u2019H\u00e9patologie, H\u00f4tel-Dieu, Lyon, France, \n\nbLaboratoire d\u2019Anatomie Pathologique, Fondation Marcel M\u00e9rieux, Lyon, France, \n\ncD\u00e9partement de Transplantation H\u00e9patique, H\u00f4pital de la Croix-Rousse, Lyon, France, \n\ndLaboratoire Central d\u2019Anatomie et Cytologie Pathologiques, H\u00f4pital Edouard Herriot, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Baulieux","sequence":"additional","affiliation":[{"name":"aUnit\u00e9 d\u2019H\u00e9patologie, H\u00f4tel-Dieu, Lyon, France, \n\nbLaboratoire d\u2019Anatomie Pathologique, Fondation Marcel M\u00e9rieux, Lyon, France, \n\ncD\u00e9partement de Transplantation H\u00e9patique, H\u00f4pital de la Croix-Rousse, Lyon, France, \n\ndLaboratoire Central d\u2019Anatomie et Cytologie Pathologiques, H\u00f4pital Edouard Herriot, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Y","family":"Scoazec","sequence":"additional","affiliation":[{"name":"aUnit\u00e9 d\u2019H\u00e9patologie, H\u00f4tel-Dieu, Lyon, France, \n\nbLaboratoire d\u2019Anatomie Pathologique, Fondation Marcel M\u00e9rieux, Lyon, France, \n\ncD\u00e9partement de Transplantation H\u00e9patique, H\u00f4pital de la Croix-Rousse, Lyon, France, \n\ndLaboratoire Central d\u2019Anatomie et Cytologie Pathologiques, H\u00f4pital Edouard Herriot, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Trepo","sequence":"additional","affiliation":[{"name":"aUnit\u00e9 d\u2019H\u00e9patologie, H\u00f4tel-Dieu, Lyon, France, \n\nbLaboratoire d\u2019Anatomie Pathologique, Fondation Marcel M\u00e9rieux, Lyon, France, \n\ncD\u00e9partement de Transplantation H\u00e9patique, H\u00f4pital de la Croix-Rousse, Lyon, France, \n\ndLaboratoire Central d\u2019Anatomie et Cytologie Pathologiques, H\u00f4pital Edouard Herriot, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1999,10,1]]},"reference":[{"key":"2025121305591070000_45.4.622.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(83)80005-7"},{"key":"2025121305591070000_45.4.622.2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198212000-00001"},{"key":"2025121305591070000_45.4.622.3","doi-asserted-by":"crossref","unstructured":"Stocker JT Ishak KG (1987) Hepatoblastoma. in Neoplasms of the liver. eds Okuda K Ishak KG (Springer Verlag, NewYork), pp 127\u2013136.","DOI":"10.1007\/978-4-431-68349-0_9"},{"key":"2025121305591070000_45.4.622.4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.1995.tb00681.x"},{"key":"2025121305591070000_45.4.622.5","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S0344-0338(11)81151-9","article-title":"Epithelial and mixed hepatoblastoma in the adult.","volume":"188","author":"Altmann","year":"1992","journal-title":"Pathol Res Pract"},{"key":"2025121305591070000_45.4.622.6","first-page":"25","article-title":"Hepatoblastoma: a clinico-pathologic review.","volume":"84","author":"Pollice","year":"1992","journal-title":"Pathologica"},{"key":"2025121305591070000_45.4.622.7","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/ajcp\/92.1.110","article-title":"Hepatoblastoma in an adult with metastasis to the ovaries.","volume":"92","author":"Green","year":"1989","journal-title":"Am J Clin 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Attempt at characterization of histologic subtypes.","volume":"6","author":"Gonzales-Crussi","year":"1982","journal-title":"Am J Surg Pathol"},{"key":"2025121305591070000_45.4.622.12","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196901)23:1<191::AID-CNCR2820230125>3.0.CO;2-6"},{"key":"2025121305591070000_45.4.622.13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199012203232510"},{"key":"2025121305591070000_45.4.622.14","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.132.6.1133"},{"key":"2025121305591070000_45.4.622.15","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(96)80203-0"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.45.4.622","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T13:59:17Z","timestamp":1765634357000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.45.4.622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,10,1]]},"references-count":15,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1999,10,1]]},"published-print":{"date-parts":[[1999,10,1]]}},"alternative-id":["10.1136\/gut.45.4.622"],"URL":"https:\/\/doi.org\/10.1136\/gut.45.4.622","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,10,1]]}}}