{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T03:32:05Z","timestamp":1775791925212,"version":"3.50.1"},"reference-count":42,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[2000,1,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>It remains controversial whether or not <jats:italic>Helicobacter pylori<\/jats:italic>infection causes altered gastric acid secretion. A novel test for evaluating gastric acid secretion (endoscopic gastrin test; EGT) has recently been developed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>AIM<\/jats:title>\n                  <jats:p>To investigate by EGT the effects of <jats:italic>H pylori<\/jats:italic>eradication on the state of gastric acid secretion in patients with peptic ulcer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec sec-type=\"methods\">\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Twenty six patients with duodenal ulcer and 33 with gastric ulcer, for all of whom<jats:italic>H pylori<\/jats:italic> infection had been documented, were studied by EGT, histological examination of gastric mucosa, and measurement of plasma gastrin levels before and one and seven months after <jats:italic>H pylori<\/jats:italic> eradication.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>In patients with duodenal ulcer, the mean EGT value before<jats:italic>H pylori<\/jats:italic> eradication was higher than that in<jats:italic>H pylori<\/jats:italic> negative controls, but it had decreased significantly seven months after the treatment. In contrast, the mean EGT value of patients with gastric ulcer before<jats:italic>H pylori<\/jats:italic> eradication was lower than that in<jats:italic>H pylori<\/jats:italic> negative controls, but it had increased one month after the treatment; this was followed by a slight decrease at seven months. In both groups, mean EGT values seven months after the treatment were not significantly different from the mean control value.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>The reduced acid secretion in gastric ulcer patients and gastric acid hypersecretion in duodenal ulcer patients were both normalised after the clearance of <jats:italic>H pylori<\/jats:italic>.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/gut.46.1.20","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:32:32Z","timestamp":1027751552000},"page":"20-26","source":"Crossref","is-referenced-by-count":100,"title":["Changes in gastric acid secretion assayed by endoscopic gastrin test before and after <i>Helicobacter pylori<\/i>eradication"],"prefix":"10.1136","volume":"46","author":[{"given":"K","family":"Iijima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Ohara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Sekine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Koike","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Asaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Shimosegawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Toyota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2000,1,1]]},"reference":[{"key":"2025090723575955000_46.1.20.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91111-8"},{"key":"2025090723575955000_46.1.20.2","doi-asserted-by":"crossref","first-page":"705","DOI":"10.7326\/0003-4819-116-9-705","article-title":"Effect of treatment of Helicobacter pylori infection on the long-term recurrence of gastric or duodenal ulcer.","volume":"116","author":"Graham","year":"1992","journal-title":"Ann Intern Med"},{"key":"2025090723575955000_46.1.20.3","first-page":"1716","article-title":"Meta-analysis of the efficacy of antibiotic therapy in eradicating Helicobacter pylori.","volume":"87","author":"Chiba","year":"1992","journal-title":"Am J Gastroenterol"},{"key":"2025090723575955000_46.1.20.4","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0140-6736(89)90728-9","article-title":"Campylobacter pylori, gastrin, acid secretion and duodenal ulcers.","volume":"2","author":"Levi","year":"1989","journal-title":"Lancet"},{"key":"2025090723575955000_46.1.20.5","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3109\/00365529109025052","article-title":"Plasma gastrin, day time intragastric pH, and nocturnal acid output before and at 1 and 7 months after eradication of Helicobacter pylori in duodenal ulcer subjects.","volume":"26","author":"McColl","year":"1991","journal-title":"Scand J Gastroentrol"},{"key":"2025090723575955000_46.1.20.6","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.7.888"},{"key":"2025090723575955000_46.1.20.7","doi-asserted-by":"publisher","DOI":"10.1136\/gut.37.2.210"},{"key":"2025090723575955000_46.1.20.8","doi-asserted-by":"publisher","DOI":"10.1136\/gut.38.5.663"},{"key":"2025090723575955000_46.1.20.9","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90374-7"},{"key":"2025090723575955000_46.1.20.10","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/00004836-199603000-00003","article-title":"Basal and stimulated gastrin levels and gastric acid output five months after therapy for Helicobacter pylori eradication in duodenal ulcer patients.","volume":"22","author":"Gisbert","year":"1996","journal-title":"J Clin Gastroenterol"},{"key":"2025090723575955000_46.1.20.11","first-page":"353","article-title":"Helicobacter pylori infection and gastric secretion in duodenal and gastric ulcer patients: the effect of eradication after one year.","volume":"48","author":"Laszewicz","year":"1997","journal-title":"J Physiol Pharmacol"},{"key":"2025090723575955000_46.1.20.12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00603.x"},{"key":"2025090723575955000_46.1.20.13","unstructured":"Misiewicz JJ Tytgat GN Goodwin CS (1990) The Sydney System; a new classification of gastritis. 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