{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T20:07:02Z","timestamp":1767125222594,"version":"3.48.0"},"reference-count":21,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[2000,2,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Sorbin, a 153 amino acid peptide isolated from porcine intestine, was localised by immunohistochemistry in endocrine cells of the intestinal mucosa and pancreas and in the enteric nervous system in the pig.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>AIMS<\/jats:title>\n                    <jats:p>To identify sorbin cells in normal human digestive tissues and to explore the expression of sorbin in 37 digestive endocrine tumours: 14 intestinal carcinoid tumours and 23 endocrine pancreatic tumours including six insulinomas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"methods\">\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Two polyclonal antibodies against the C-terminal and the N-terminal sequences of porcine sorbin raised in rabbit were used to evaluate sorbin expression by immunohistochemistry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>In the human digestive tract, sorbin, characterised by both C-terminal and N-terminal immunoreactivity, was found in enterochromaffin cells of the gastric and intestinal epithelium from the pyloric junction to the descending colon. C-Terminal sorbin immunoreactivity alone was found in plexii from the enteric nervous system and in some insulin-containing cells of normal pancreas. C-Terminal and N-terminal antibodies disclosed sorbin in five of 14 intestinal carcinoid tumours; C-terminal antibody alone disclosed a C-terminal sorbin peptide in two of six insulinomas and three of 17 endocrine pancreatic tumours. The presence of sorbin was not associated with a specific clinical syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Sorbin is present in the digestive tract in several forms. It is expressed in some intestinal and pancreatic endocrine tumours.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gut.46.2.182","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:32:32Z","timestamp":1027751552000},"page":"182-190","source":"Crossref","is-referenced-by-count":5,"title":["Presence of sorbin in human digestive tract and endocrine digestive tumours"],"prefix":"10.1136","volume":"46","author":[{"given":"F Abou","family":"El Fadil-Nicol","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Berger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Descroix-Vagne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Pansu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2000,2,1]]},"reference":[{"key":"2025121313242482000_46.2.182.1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1432-1033.1991.tb16254.x","article-title":"Isolation and characterisation of porcine sorbin.","volume":"201","author":"Vagne-Descroix","year":"1991","journal-title":"Eur J Biochem"},{"key":"2025121313242482000_46.2.182.2","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1016\/0016-5085(92)91179-8","article-title":"Effect of sorbin on duodenal absorption of water and electrolytes in the rat.","volume":"103","author":"Charpin","year":"1992","journal-title":"Gastroenterology"},{"key":"2025121313242482000_46.2.182.3","first-page":"702","article-title":"Effet des d\u00e9riv\u00e9s C-terminaux de la sorbine sur les flux ioniques ileaux stimul\u00e9s par le VIP chez le rat.","volume":"18","author":"Marquet","year":"1994","journal-title":"Gastroenterol Clin Biol"},{"key":"2025121313242482000_46.2.182.4","first-page":"487","article-title":"Effet des d\u00e9riv\u00e9s C-terminaux de la sorbine sur les flux ioniques duod\u00e9naux chez le rat.","volume":"19","author":"Grishina","year":"1995","journal-title":"Gastroenterol Clin Biol"},{"key":"2025121313242482000_46.2.182.5","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/S0196-9781(98)00082-5","article-title":"Effect of sorbin derivatives on cholera toxin-induced intestinal secretion in rat in vivo.","volume":"19","author":"Marquet","year":"1998","journal-title":"Peptides"},{"key":"2025121313242482000_46.2.182.6","first-page":"G107","article-title":"Effect of sorbin on electrolyte transport in rat and human intestine.","volume":"276","author":"Eto","year":"1999","journal-title":"Am J Physiol"},{"doi-asserted-by":"publisher","key":"2025121313242482000_46.2.182.7","DOI":"10.1210\/en.138.11.4989"},{"key":"2025121313242482000_46.2.182.8","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/0016-5085(80)90439-4","article-title":"Immunoreactive somatostatin and vasoactive intestinal peptide in the digestive tract of cat.","volume":"79","author":"Chayvialle","year":"1980","journal-title":"Gastroenterology"},{"key":"2025121313242482000_46.2.182.9","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/0016-5085(89)90380-6","article-title":"Immunocytochemical study of peptidergic structures in Brunner's glands.","volume":"97","author":"Bosshard","year":"1989","journal-title":"Gastroenterology"},{"key":"2025121313242482000_46.2.182.10","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/S0016-5085(85)80082-2","article-title":"Jejunal secretory effect of intraduodenal food in humans.","volume":"88","author":"Miazza","year":"1985","journal-title":"Gastroenterology"},{"doi-asserted-by":"publisher","key":"2025121313242482000_46.2.182.11","DOI":"10.1016\/0196-9781(95)02045-4"},{"key":"2025121313242482000_46.2.182.12","first-page":"3","article-title":"Silver stains in the study of endocrine cells of the gut and pancreas.","volume":"3","author":"Grimelius","year":"1980","journal-title":"Cell Pathol"},{"key":"2025121313242482000_46.2.182.13","first-page":"81","article-title":"A modification of the Masson-Hamperl method for staining of argentaffin cells.","volume":"115","author":"Singh","year":"1964","journal-title":"Anat Anz"},{"unstructured":"Abou El Fadil-Nicol (1997) Distribution de la sorbine dans le tractus digestif du porc, du rat et de l'homme. 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