{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:57:01Z","timestamp":1790517421135,"version":"4.1.0"},"reference-count":40,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[2000,2,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Ingestion of a meal stimulates colonic motility. It is unclear whether the nutrient composition of a meal affects colonic motor response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>AIMS<\/jats:title>\n                    <jats:p>To investigate and compare the effects of a predominantly fat or carbohydrate meal on colonic motility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"methods\">\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>In 18 healthy subjects, ambulatory colonic manometry was performed by placing a six sensor, solid state probe from the mid-transverse colon to the rectum. In a randomised, crossover design, 10 and 27 hours after probe placement, subjects received 4.18 MJ meals containing 60% calories from fat or carbohydrate sources. Preprandial and postprandial pressure activity and motor patterns were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Both meals induced phasic activity with a greater area under the curve (p&lt;0.03) in the first postprandial hour, compared with the control period. Fat induced motor activity persisted longer (p&lt;0.05) than that of the carbohydrate meal, but the onset of motor response was slower (p&lt;0.001). Although both meals induced more (p&lt;0.001) propagating pressure waves, only the fat meal induced more (p&lt;0.05) simultaneous and retrograde waves. After both meals, 50% of subjects exhibited high amplitude (more than 103 mm Hg), prolonged duration (more than 13 seconds) propagating waves. Both meals induced greater activity (p&lt;0.05) in the transverse\/descending colon than in the rectosigmoid colon.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Carbohydrate meals induce colonic motor response, but the effects are short lived when compared with fat meals. The prolonged, segmental, and retrograde phasic activity induced by the fat meal may delay colon transit. Thus meal composition influences colonic motor response.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gut.46.2.205","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:32:32Z","timestamp":1027751552000},"page":"205-211","source":"Crossref","is-referenced-by-count":99,"title":["Effects of fat and carbohydrate meals on colonic motor response"],"prefix":"10.1136","volume":"46","author":[{"given":"S S C","family":"Rao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Kavelock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Beaty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Ackerson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Stumbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2000,2,1]]},"reference":[{"key":"2025120619064475000_46.2.205.1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1113\/jphysiol.1913.sp001613","article-title":"The normal movements of the colon in man.","volume":"47","author":"Hertz","year":"1913","journal-title":"Am J Physiol"},{"key":"2025120619064475000_46.2.205.2","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/0016-5085(88)90005-4","article-title":"Participation of gastric mechanoreceptors and intestinal chemoreceptors in the gastrocolonic response.","volume":"94","author":"Wiley","year":"1988","journal-title":"Gastroenterology"},{"key":"2025120619064475000_46.2.205.3","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0016-5085(74)80136-8","article-title":"Effect of intraduodenal administration of essential amino acids and sodium oleate on motor activity of the sigmoid colon.","volume":"66","author":"Meshkinpour","year":"1974","journal-title":"Gastroenterology"},{"key":"2025120619064475000_46.2.205.4","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/0016-5085(78)90864-8","article-title":"Colonic response to eating.","volume":"75","author":"Duthie","year":"1978","journal-title":"Gastroenterology"},{"key":"2025120619064475000_46.2.205.5","doi-asserted-by":"publisher","DOI":"10.1007\/BF01297155"},{"key":"2025120619064475000_46.2.205.6","first-page":"G830","article-title":"Colonic motor response to a meal in dogs.","volume":"257","author":"Sarna","year":"1989","journal-title":"Am J Physiol"},{"key":"2025120619064475000_46.2.205.7","first-page":"415","article-title":"Factors which control colonic motility: responses to meals of the proximal and distal colon in patients with gastroectomy, duodenal ulcer, or pernicious anaemia.","volume":"10","author":"Holdstock","year":"1996","journal-title":"Gut"},{"key":"2025120619064475000_46.2.205.8","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/0016-5085(83)90144-0","article-title":"Motor responses to food of the ileum, proximal colon and distal colon of healthy humans.","volume":"84","author":"Kerlin","year":"1983","journal-title":"Gastoenterology"},{"key":"2025120619064475000_46.2.205.9","doi-asserted-by":"publisher","DOI":"10.1136\/gut.11.2.91"},{"key":"2025120619064475000_46.2.205.10","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.8.1009"},{"key":"2025120619064475000_46.2.205.11","doi-asserted-by":"publisher","DOI":"10.1159\/000199488"},{"key":"2025120619064475000_46.2.205.12","doi-asserted-by":"publisher","DOI":"10.1136\/gut.37.2.264"},{"key":"2025120619064475000_46.2.205.13","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/S0016-5085(89)80013-7","article-title":"Association between postprandial changes in colonic intraluminal pressure and transit.","volume":"96","author":"Moreno-Osset","year":"1989","journal-title":"Gastroenterology"},{"key":"2025120619064475000_46.2.205.14","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/0016-5085(79)90162-8","article-title":"The gastrocolonic response. 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