{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:09:33Z","timestamp":1761862173452,"version":"3.44.0"},"reference-count":32,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[2000,3,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Virulence factors of<jats:italic>Helicobacter pylori<\/jats:italic> are associated with peptic ulcer disease and may be also associated with the efficacy of treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>AIMS<\/jats:title>\n                  <jats:p>To determine the relation between the <jats:italic>vacA<\/jats:italic> and the<jats:italic>cagA<\/jats:italic> status of <jats:italic>H pylori,<\/jats:italic> clinical disease, and treatment outcome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>PATIENTS<\/jats:title>\n                  <jats:p>121 patients with<jats:italic>H pylori<\/jats:italic> infection and peptic ulcer disease or functional dyspepsia were treated by quadruple antibiotic therapy in two groups for one and two days, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec sec-type=\"methods\">\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>DNA was isolated from gastric antral biopsy specimens, taken before and after treatment, and the <jats:italic>vacA<\/jats:italic> and <jats:italic>cagA<\/jats:italic>status was determined by polymerase chain reaction and reverse hybridisation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Peptic ulcer disease was significantly associated with the <jats:italic>vacA<\/jats:italic> s1 type, and <jats:italic>cagA<\/jats:italic> positivity, but not with the<jats:italic>vacA<\/jats:italic> m type. Treatment efficacy was significantly higher in patients with peptic ulcer disease, or infected with <jats:italic>cagA<\/jats:italic>+\/<jats:italic>vacA<\/jats:italic>s1 strains.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>The strong association between the <jats:italic>cagA<\/jats:italic> and<jats:italic>vacA<\/jats:italic> status and peptic ulcer disease was confirmed. Cure rates seem to be higher for patients with<jats:italic>cagA<\/jats:italic>+\/<jats:italic>vacA<\/jats:italic> s1<jats:italic>H pylori <\/jats:italic>strains, which is consistent with the higher cure rate observed among ulcer patients compared with functional dyspepsia patients. Therefore, treatment studies may require stratification for presence of ulcers as well as <jats:italic>H pylori<\/jats:italic> genotypes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/gut.46.3.321","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:32:32Z","timestamp":1027751552000},"page":"321-326","source":"Crossref","is-referenced-by-count":106,"title":["Importance of <i>Helicobacter pylori cagA<\/i> and <i>vacA<\/i>status for the efficacy of antibiotic treatment"],"prefix":"10.1136","volume":"46","author":[{"given":"L-J","family":"van Doorn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P M","family":"Schneeberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Nouhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A 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