{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:21:44Z","timestamp":1790896904449,"version":"4.1.0"},"reference-count":22,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[2000,4,4]]},"published-print":{"date-parts":[[2000,9,1]]},"abstract":"\n BACKGROUND<\/jats:title>\n In selective IgA deficiency (IgAD), there is no reliable screening test for coeliac disease (CD).<\/jats:p>\n <\/jats:sec>\n \n AIM<\/jats:title>\n \n To evaluate the usefulness of IgG\n 1<\/jats:sub>\n antiendomysium and IgG antitissue transglutaminase tests for CD diagnosis in IgAD.\n <\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n \n IgA and IgG antigliadin antibodies (IgA- and IgG-AGA), IgA and IgG\n 1<\/jats:sub>\n antiendomysium antibodies (IgA- and IgG\n 1<\/jats:sub>\n -EMA), and IgA and IgG antitissue transglutaminase (IgA- and IgG-anti-tTG) were assayed in: (a) 20 untreated IgAD\/CD patients; (b) 34 IgAD\/CD patients on a strict gluten free diet (GFD); (c) 10 IgAD\/CD patients not on a strict GFD; (d) 11 untreated CD patients without IgAD; (e) 10 healthy IgAD patients; and (f) 25 healthy controls.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n In all untreated IgAD\/CD patients, IgG\n 1<\/jats:sub>\n -EMA, IgG-anti-tTG, and IgG-AGA were positive whereas IgA antibodies against these antigens were negative. IgAD\/CD patients on a strict GFD did not produce IgG-AGA or IgG\n 1<\/jats:sub>\n -EMA but four of 34 produced IgG anti-tTG. IgAD\/CD subjects not on a strict GFD produced IgG-AGA whereas 5\/10 and 4\/10 were IgG\n 1<\/jats:sub>\n - EMA and IgG-anti-tTG negative, respectively. Untreated CD patients without IgAD were AGA (IgA and IgG), EMA (IgA and IgG\n 1<\/jats:sub>\n ), and anti-tTG (IgA and IgG) positive. Healthy controls were AGA and EMA negative whereas two of 10 apparently healthy IgAD subjects and one of 25 healthy negative control were IgG-anti-tTG positive.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n \n Both IgG\n 1<\/jats:sub>\n -EMA and IgG-anti-tTG tests appear to be useful for identification of IgAD\/CD patients whereas they are less satisfactory for monitoring dietary compliance in these subjects. In addition, our findings seem to suggest that IgG-EMA autoantibodies produced by coeliac patients are mainly of the IgG\n 1<\/jats:sub>\n subtype.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/gut.47.3.366","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:32:32Z","timestamp":1027751552000},"page":"366-369","source":"Crossref","is-referenced-by-count":103,"title":["IgG\n 1<\/sub>\n antiendomysium and IgG antitissue transglutaminase (anti-tTG) antibodies in coeliac patients with selective IgA deficiency"],"prefix":"10.1136","volume":"47","author":[{"given":"F","family":"Cataldo","sequence":"first","affiliation":[{"name":"aClinica Pediatrica R and Dipartimento di Biopatologia, University of Palermo, Italy, \n\nbClinica Medica 2, La Sapienza University, Roma, Italy, \n\ncClinica Pediatrica, University of Trieste, Italy, \n\ndChair of Gastroenterology, Policlinico S Matteo, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Lio","sequence":"additional","affiliation":[{"name":"aClinica Pediatrica R and Dipartimento di Biopatologia, University of Palermo, Italy, \n\nbClinica Medica 2, La Sapienza University, Roma, Italy, \n\ncClinica Pediatrica, University of Trieste, Italy, \n\ndChair of Gastroenterology, Policlinico S Matteo, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Marino","sequence":"additional","affiliation":[{"name":"aClinica Pediatrica R and Dipartimento di Biopatologia, University of Palermo, Italy, \n\nbClinica Medica 2, La Sapienza University, Roma, Italy, \n\ncClinica Pediatrica, University of Trieste, Italy, \n\ndChair of Gastroenterology, Policlinico S Matteo, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Picarelli","sequence":"additional","affiliation":[{"name":"aClinica Pediatrica R and Dipartimento di Biopatologia, University of Palermo, Italy, \n\nbClinica Medica 2, La Sapienza University, Roma, Italy, \n\ncClinica Pediatrica, University of Trieste, Italy, \n\ndChair of Gastroenterology, Policlinico S Matteo, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Ventura","sequence":"additional","affiliation":[{"name":"aClinica Pediatrica R and Dipartimento di Biopatologia, University of Palermo, Italy, \n\nbClinica Medica 2, La Sapienza University, Roma, Italy, \n\ncClinica Pediatrica, University of Trieste, Italy, \n\ndChair of Gastroenterology, Policlinico S Matteo, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G R","family":"Corazza","sequence":"additional","affiliation":[{"name":"aClinica Pediatrica R and Dipartimento di Biopatologia, University of Palermo, Italy, \n\nbClinica Medica 2, La Sapienza University, Roma, Italy, \n\ncClinica Pediatrica, University of Trieste, Italy, \n\ndChair of Gastroenterology, Policlinico S Matteo, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"the Working Groups on Celiac Diseas","family":"SIGEP and Club del Tenue","sequence":"additional","affiliation":[{"name":"aClinica Pediatrica R and Dipartimento di Biopatologia, University of Palermo, Italy, \n\nbClinica Medica 2, La Sapienza University, Roma, Italy, \n\ncClinica Pediatrica, University of Trieste, Italy, \n\ndChair of Gastroenterology, Policlinico S Matteo, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2000,9,1]]},"reference":[{"key":"2025121302400706000_47.3.366.1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529209000089"},{"key":"2025121302400706000_47.3.366.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70172-0"},{"key":"2025121302400706000_47.3.366.3","doi-asserted-by":"publisher","DOI":"10.1136\/gut.42.3.362"},{"key":"2025121302400706000_47.3.366.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70008-3"},{"key":"2025121302400706000_47.3.366.5","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199901000-00008"},{"key":"2025121302400706000_47.3.366.6","doi-asserted-by":"publisher","DOI":"10.1038\/nm0797-797"},{"key":"2025121302400706000_47.3.366.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70007-1"},{"key":"2025121302400706000_47.3.366.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70040-X"},{"key":"2025121302400706000_47.3.366.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(99)70410-5"},{"key":"2025121302400706000_47.3.366.10","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.1998.0253"},{"key":"2025121302400706000_47.3.366.11","unstructured":"Di Tola M Sabbatella L Di Giovanbattista E (1998) Antiendomysial antibodies: new evidences. 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