{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T23:32:05Z","timestamp":1770679925781,"version":"3.49.0"},"reference-count":34,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[2000,4,28]]},"published-print":{"date-parts":[[2000,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND AND AIMS<\/jats:title>\n                    <jats:p>\n                      Treatment of functional dyspepsia with acid inhibitors is controversial and it is not known if the presence of\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      infection influences the response.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"methods\">\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      After a complete diagnostic workup, 792 patients with functional dyspepsia unresponsive to one week of low dose antacid treatment were randomised to two weeks of treatment with placebo, ranitidine 150 mg, omeprazole 10 mg, or omeprazole 20 mg daily. Individual dyspeptic and other abdominal symptoms were evaluated before and after treatment according to\n                      <jats:italic>H pylori<\/jats:italic>\n                      status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The proportions of patients considered to be in remission (intention to treat) at the end of treatment with placebo, ranitidine 150 mg, omeprazole 10\u2002mg, and omeprazole 20 mg were, respectively, 42%, 50%, 48%, and 59% in the\n                      <jats:italic>H pylori<\/jats:italic>\n                      positive group and 66%, 73%, 64%, and 71% in the\n                      <jats:italic>H pylori<\/jats:italic>\n                      negative group. In\n                      <jats:italic>H pylori<\/jats:italic>\n                      positive patients, the therapeutic gain over placebo was significant for omeprazole 20 mg (17.6%, 95% confidence intervals (CI) 4.2\u201331.0; p&lt;0.014 using the Bonferroni-adjusted p level of 0.017) but not for omeprazole 10 mg (6.8%, 95% CI \u22126.7\u201320.4) or ranitidine 150 mg (8.9%, 95% CI \u22124.2\u201321.9). There was no significant therapeutic gain from active treatment over placebo in\n                      <jats:italic>H pylori<\/jats:italic>\n                      negative patients. Complete disappearance of symptoms and improvement in quality of life also occurred most frequently with omeprazole 20 mg and was significant in both\n                      <jats:italic>H pylori<\/jats:italic>\n                      positive and\n                      <jats:italic>H pylori<\/jats:italic>\n                      negative groups. The six month relapse rate of symptoms requiring treatment was low (&lt;20%) in all groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      Omeprazole 20 mg per day had a small but significant favourable effect on outcome in\n                      <jats:italic>H pylori<\/jats:italic>\n                      positive patients. The differential response in these patients may be explained by an enhanced antisecretory response in the presence of\n                      <jats:italic>H pylori.<\/jats:italic>\n                      The effect of weaker acid inhibition was unsatisfactory.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gut.47.4.473","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:37:59Z","timestamp":1027751879000},"page":"473-480","source":"Crossref","is-referenced-by-count":81,"title":["Short course acid suppressive treatment for patients with functional dyspepsia: results depend on\n                    <i>Helicobacter pylori<\/i>\n                    status"],"prefix":"10.1136","volume":"47","author":[{"given":"A L","family":"Blum","sequence":"first","affiliation":[{"name":"aDivision of Gastroenterology, Department of Medicine, University Hospital, Lausanne, Switzerland, \n\nbCentre of Internal Medicine, Philipps-University, Marburg, Germany, \n\ncInstitute of Pathology, Bayreuth, Germany, \n\ndInstitut f\u00fcr numerische Statistik, K\u00f6ln, Germany, \n\neDepartment of Medicine, Triemli Hospital, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Arnold","sequence":"additional","affiliation":[{"name":"aDivision of Gastroenterology, Department of Medicine, University Hospital, Lausanne, Switzerland, \n\nbCentre of Internal Medicine, Philipps-University, Marburg, Germany, \n\ncInstitute of Pathology, Bayreuth, Germany, \n\ndInstitut f\u00fcr numerische Statistik, K\u00f6ln, Germany, \n\neDepartment of Medicine, Triemli Hospital, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Stolte","sequence":"additional","affiliation":[{"name":"aDivision of Gastroenterology, Department of Medicine, University Hospital, Lausanne, Switzerland, \n\nbCentre of Internal Medicine, Philipps-University, Marburg, Germany, \n\ncInstitute of Pathology, Bayreuth, Germany, \n\ndInstitut f\u00fcr numerische Statistik, K\u00f6ln, Germany, \n\neDepartment of Medicine, Triemli Hospital, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Fischer","sequence":"additional","affiliation":[{"name":"aDivision of Gastroenterology, Department of Medicine, University Hospital, Lausanne, Switzerland, \n\nbCentre of Internal Medicine, Philipps-University, Marburg, Germany, \n\ncInstitute of Pathology, Bayreuth, Germany, \n\ndInstitut f\u00fcr numerische Statistik, K\u00f6ln, Germany, \n\neDepartment of Medicine, Triemli Hospital, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H R","family":"Koelz","sequence":"additional","affiliation":[{"name":"aDivision of Gastroenterology, Department of Medicine, University Hospital, Lausanne, Switzerland, \n\nbCentre of Internal Medicine, Philipps-University, Marburg, Germany, \n\ncInstitute of Pathology, Bayreuth, Germany, \n\ndInstitut f\u00fcr numerische Statistik, K\u00f6ln, Germany, \n\neDepartment of Medicine, Triemli Hospital, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Frosch Study Group\u2020","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2000,10,1]]},"reference":[{"key":"2025121221461166000_47.4.473.1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1998.00410.x"},{"key":"2025121221461166000_47.4.473.2","doi-asserted-by":"publisher","DOI":"10.1080\/00365529850172340"},{"key":"2025121221461166000_47.4.473.3","unstructured":"Talley NJ , ed (1998) Dyspepsia. 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