{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:40:56Z","timestamp":1790206856189,"version":"4.1.0"},"reference-count":20,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[2000,8,8]]},"published-print":{"date-parts":[[2001,2,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Steroid dependent patients with Crohn's disease are at high risk of developing glucocorticosteroid induced side effects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>AIMS<\/jats:title>\n                  <jats:p>We evaluated the possibility of switching from systemic steroids to budesonide (Entocort) in prednisolone\/prednisone dependent patients with inactive Crohn's disease affecting the ileum and\/or ascending colon.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>PATIENTS<\/jats:title>\n                  <jats:p>Steroid dependent patients with a Crohn's disease activity index \u2a7d200 were included.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec sec-type=\"methods\">\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>In a double blind multicentre trial, 120 patients were randomly assigned to receive budesonide 6 mg once daily or placebo. Prednisolone was tapered to zero during the first 4\u201310 weeks and budesonide or placebo was given concomitantly and for a further 12 weeks. Relapse was defined as an index &gt;200 and an increase of 60 points from baseline or withdrawal due to disease deterioration.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>After one and 13 weeks without prednisolone, relapse rates were 17% and 32%, respectively, in the budesonide group, and 41% and 65% in the placebo group (95% confidence intervals for the difference in percentages \u221241%, \u22128% and \u221251%, \u221216%; p=0.004 and p&lt;0.001, respectively). The number of glucocorticosteroid side effects was reduced by 50% by switching from prednisolone and was similar in the budesonide and placebo groups. Basal plasma cortisol increased in both groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>The majority of patients with steroid dependent ileocaecal Crohn's disease may be switched to budesonide controlled ileal release capsules 6 mg without relapse, resulting in a sharp decrease in glucocorticosteroid side effects similar to placebo, and with an increase in plasma cortisol levels.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/gut.48.2.186","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:32:32Z","timestamp":1027751552000},"page":"186-190","source":"Crossref","is-referenced-by-count":80,"title":["Switch from systemic steroids to budesonide in steroid dependent patients with inactive Crohn's disease"],"prefix":"10.1136","volume":"48","author":[{"given":"A","family":"Cortot","sequence":"first","affiliation":[{"name":"aService de Gastroenterologie, H\u00f4pital Claude Huriez, Lille, France, \n\nbDepartment of Gastroenterology, University Hospital of Leuven, Belgium, \n\ncDepartment of Medical Gastroenterology, University Hospital of Odense, Denmark, \n\ndMedizinische Klinik II, St\u00e4dtisches Krankenhaus Leverkusen, Germany, \n\neKrankenhaus Tabea, Hamburg, Germany, \n\nfDepartment of Gastroenterology, Groote Schuur Hospital, Cape Town, South Africa, \n\ngService de Gastroent\u00e9rologie, H\u00f4pital Erasme, Bruxelles, Belgium, \n\nhClinical Resear"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-F","family":"Colombel","sequence":"additional","affiliation":[{"name":"aService de Gastroenterologie, H\u00f4pital Claude Huriez, Lille, France, \n\nbDepartment of Gastroenterology, University Hospital of Leuven, Belgium, \n\ncDepartment of Medical Gastroenterology, University Hospital of Odense, Denmark, \n\ndMedizinische Klinik II, St\u00e4dtisches Krankenhaus Leverkusen, Germany, \n\neKrankenhaus Tabea, Hamburg, Germany, \n\nfDepartment of Gastroenterology, Groote Schuur Hospital, Cape Town, South Africa, \n\ngService de Gastroent\u00e9rologie, H\u00f4pital Erasme, Bruxelles, Belgium, \n\nhClinical Resear"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Rutgeerts","sequence":"additional","affiliation":[{"name":"aService de Gastroenterologie, H\u00f4pital Claude Huriez, Lille, France, \n\nbDepartment of Gastroenterology, University Hospital of Leuven, Belgium, \n\ncDepartment of Medical Gastroenterology, University Hospital of Odense, Denmark, \n\ndMedizinische Klinik II, St\u00e4dtisches Krankenhaus Leverkusen, Germany, \n\neKrankenhaus Tabea, Hamburg, Germany, \n\nfDepartment of Gastroenterology, Groote Schuur Hospital, Cape Town, South Africa, \n\ngService de Gastroent\u00e9rologie, H\u00f4pital Erasme, Bruxelles, Belgium, \n\nhClinical Resear"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Lauritsen","sequence":"additional","affiliation":[{"name":"aService de Gastroenterologie, H\u00f4pital Claude Huriez, Lille, France, \n\nbDepartment of Gastroenterology, University Hospital of Leuven, Belgium, \n\ncDepartment of Medical Gastroenterology, University Hospital of Odense, Denmark, \n\ndMedizinische Klinik II, St\u00e4dtisches Krankenhaus Leverkusen, Germany, \n\neKrankenhaus Tabea, Hamburg, Germany, \n\nfDepartment of Gastroenterology, Groote Schuur Hospital, Cape Town, South Africa, \n\ngService de Gastroent\u00e9rologie, H\u00f4pital Erasme, Bruxelles, Belgium, \n\nhClinical Resear"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Malchow","sequence":"additional","affiliation":[{"name":"aService de Gastroenterologie, H\u00f4pital Claude Huriez, Lille, France, \n\nbDepartment of Gastroenterology, University Hospital of Leuven, Belgium, \n\ncDepartment of Medical Gastroenterology, University Hospital of Odense, Denmark, \n\ndMedizinische Klinik II, St\u00e4dtisches Krankenhaus Leverkusen, Germany, \n\neKrankenhaus Tabea, Hamburg, Germany, \n\nfDepartment of Gastroenterology, Groote Schuur Hospital, Cape Town, South Africa, \n\ngService de Gastroent\u00e9rologie, H\u00f4pital Erasme, Bruxelles, Belgium, \n\nhClinical Resear"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"H\u00e4mling","sequence":"additional","affiliation":[{"name":"aService de Gastroenterologie, H\u00f4pital Claude Huriez, Lille, France, \n\nbDepartment of Gastroenterology, University Hospital of Leuven, Belgium, \n\ncDepartment of Medical Gastroenterology, University Hospital of Odense, Denmark, \n\ndMedizinische Klinik II, St\u00e4dtisches Krankenhaus Leverkusen, Germany, \n\neKrankenhaus Tabea, Hamburg, Germany, \n\nfDepartment of Gastroenterology, Groote Schuur Hospital, Cape Town, South Africa, \n\ngService de Gastroent\u00e9rologie, H\u00f4pital Erasme, Bruxelles, Belgium, \n\nhClinical Resear"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Winter","sequence":"additional","affiliation":[{"name":"aService de Gastroenterologie, H\u00f4pital Claude Huriez, Lille, France, \n\nbDepartment of Gastroenterology, University Hospital of Leuven, Belgium, \n\ncDepartment of Medical Gastroenterology, University Hospital of Odense, Denmark, \n\ndMedizinische Klinik II, St\u00e4dtisches Krankenhaus Leverkusen, Germany, \n\neKrankenhaus Tabea, Hamburg, Germany, \n\nfDepartment of Gastroenterology, Groote Schuur Hospital, Cape Town, South Africa, \n\ngService de Gastroent\u00e9rologie, H\u00f4pital Erasme, Bruxelles, Belgium, \n\nhClinical Resear"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Van Gossum","sequence":"additional","affiliation":[{"name":"aService de Gastroenterologie, H\u00f4pital Claude Huriez, Lille, France, \n\nbDepartment of Gastroenterology, University Hospital of Leuven, Belgium, \n\ncDepartment of Medical Gastroenterology, University Hospital of Odense, Denmark, \n\ndMedizinische Klinik II, St\u00e4dtisches Krankenhaus Leverkusen, Germany, \n\neKrankenhaus Tabea, Hamburg, Germany, \n\nfDepartment of Gastroenterology, Groote Schuur Hospital, Cape Town, South Africa, \n\ngService de Gastroent\u00e9rologie, H\u00f4pital Erasme, Bruxelles, Belgium, \n\nhClinical Resear"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Persson","sequence":"additional","affiliation":[{"name":"aService de Gastroenterologie, H\u00f4pital Claude Huriez, Lille, France, \n\nbDepartment of Gastroenterology, University Hospital of Leuven, Belgium, \n\ncDepartment of Medical Gastroenterology, University Hospital of Odense, Denmark, \n\ndMedizinische Klinik II, St\u00e4dtisches Krankenhaus Leverkusen, Germany, \n\neKrankenhaus Tabea, Hamburg, Germany, \n\nfDepartment of Gastroenterology, Groote Schuur Hospital, Cape Town, South Africa, 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A dose-finding study.","volume":"112","author":"Gross","year":"1997","journal-title":"Gastroenterology"},{"key":"2025090800441119000_48.2.186.16","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70019-3"},{"key":"2025090800441119000_48.2.186.17","first-page":"A689","article-title":"Quality of life in Crohn's disease: a prospective longitudinal study in 231 patients.","volume":"116","author":"Colombel","year":"1999","journal-title":"Gastroenterology"},{"key":"2025090800441119000_48.2.186.18","doi-asserted-by":"crossref","first-page":"132","DOI":"10.7326\/0003-4819-123-2-199507150-00009","article-title":"Azathioprine and 6-mercaptopurine in Crohn's disease. A meta-analysis.","volume":"122","author":"Pearson","year":"1995","journal-title":"Ann Intern Med"},{"key":"2025090800441119000_48.2.186.19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199502023320503"},{"key":"2025090800441119000_48.2.186.20","doi-asserted-by":"publisher","DOI":"10.1159\/000007523"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.48.2.186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T07:44:20Z","timestamp":1757317460000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.48.2.186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2,1]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2001,2,1]]},"published-print":{"date-parts":[[2001,2,1]]}},"alternative-id":["10.1136\/gut.48.2.186"],"URL":"https:\/\/doi.org\/10.1136\/gut.48.2.186","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,2,1]]}}}