{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:39:21Z","timestamp":1790393961591,"version":"4.1.0"},"reference-count":25,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[2000,7,21]]},"published-print":{"date-parts":[[2001,3,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND AND AIMS<\/jats:title>\n                    <jats:p>\n                      Discrepant remission rates (41\u2013100%) have been reported for patients with localised low grade gastric mucosa associated lymphoid tissue (MALT) lymphoma after eradication of\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      . The aim of this study was to explain these discrepancies and to determine the predictive factors of gastric lymphoma regression after anti-\n                      <jats:italic>H pylori<\/jats:italic>\n                      treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PATIENTS AND METHODS<\/jats:title>\n                    <jats:p>\n                      Forty six consecutive patients with localised gastric MALT lymphoma (Ann Arbor stages I\n                      <jats:sub>E<\/jats:sub>\n                      and II\n                      <jats:sub>E<\/jats:sub>\n                      ) were prospectively enrolled. All had gastric endoscopic ultrasonography and\n                      <jats:italic>H pylori<\/jats:italic>\n                      status assessment (histology, culture, polymerase chain reaction, and serology). After anti-\n                      <jats:italic>H pylori<\/jats:italic>\n                      treatment, patients were re-examined every four months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Histological regression of the lymphoma was complete in 19\/44 patients (43%) (two lost to follow up). Median follow up time for these 19 responders was 35 months (range 10\u201347). No regression was noted in the 10\n                      <jats:italic>H pylori<\/jats:italic>\n                      negative patients. Among the 34\n                      <jats:italic>H pylori<\/jats:italic>\n                      positive patients, the\n                      <jats:italic>H pylori<\/jats:italic>\n                      eradication rate was 100%; complete regression rate of the lymphoma increased from 56% (19\/34) to 79% (19\/24) when there was no nodal involvement at endoscopic ultrasonography. There was a significant difference between the response of the lymphoma restricted to the mucosa and other more deep seated lesions (p&lt;0.006). However, using multivariate analysis, the only predictive factor of regression was the absence of nodal involvement (p&lt;0.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      In\n                      <jats:italic>H pylori<\/jats:italic>\n                      positive patients with localised gastric MALT lymphoma, carefully evaluated and treated without any lymph node involvement assessed by endoscopic ultrasonography, complete remission of lymphoma was reached in 79% of cases.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gut.48.3.297","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:32:32Z","timestamp":1027751552000},"page":"297-303","source":"Crossref","is-referenced-by-count":234,"title":["Predictive factors for regression of gastric MALT lymphoma after anti-\n                    <i>Helicobacter pylori<\/i>\n                    treatment"],"prefix":"10.1136","volume":"48","author":[{"given":"A","family":"Ruskon\u00e9-Fourmestraux","sequence":"first","affiliation":[{"name":"aDepartment of Gastroenterology, H\u00f4tel-Dieu, AP-HP, Paris, France, \n        bH\u00f4pital Lariboisi\u00e8re, Paris, France, \n        cDepartment of Pathology, H\u00f4pital Lariboisi\u00e8re, AP-HP, Paris, France, \n        dH\u00f4tel Dieu, AP-HP, Paris, France, \n        eDepartment of Biostatistics, H\u00f4pital Ambroise Par\u00e9, Boulogne, France, \n        fDepartment of Pathology, University of Bordeaux, France, \n        gDepartment of Bacteriology, University of Bordeaux, France, \n        hFondation Fran\u00e7aise de Canc\u00e9rologie Dig"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Lavergne","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology, H\u00f4tel-Dieu, AP-HP, Paris, France, \n        bH\u00f4pital Lariboisi\u00e8re, Paris, France, \n        cDepartment of Pathology, H\u00f4pital Lariboisi\u00e8re, AP-HP, Paris, France, \n        dH\u00f4tel Dieu, AP-HP, Paris, France, \n        eDepartment of Biostatistics, H\u00f4pital Ambroise Par\u00e9, Boulogne, France, \n        fDepartment of Pathology, University of Bordeaux, France, \n        gDepartment of Bacteriology, University of Bordeaux, France, \n        hFondation Fran\u00e7aise de Canc\u00e9rologie Dig"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P H","family":"Aegerter","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology, H\u00f4tel-Dieu, AP-HP, Paris, France, \n        bH\u00f4pital Lariboisi\u00e8re, Paris, France, \n        cDepartment of Pathology, H\u00f4pital Lariboisi\u00e8re, AP-HP, Paris, France, \n        dH\u00f4tel Dieu, AP-HP, Paris, France, \n        eDepartment of Biostatistics, H\u00f4pital Ambroise Par\u00e9, Boulogne, France, \n        fDepartment of Pathology, University of Bordeaux, France, \n        gDepartment of Bacteriology, University of Bordeaux, France, \n        hFondation Fran\u00e7aise de Canc\u00e9rologie Dig"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Megraud","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology, H\u00f4tel-Dieu, AP-HP, Paris, France, \n        bH\u00f4pital Lariboisi\u00e8re, Paris, France, \n        cDepartment of Pathology, H\u00f4pital Lariboisi\u00e8re, AP-HP, Paris, France, \n        dH\u00f4tel Dieu, AP-HP, Paris, France, \n        eDepartment of Biostatistics, H\u00f4pital Ambroise Par\u00e9, Boulogne, France, \n        fDepartment of Pathology, University of Bordeaux, France, \n        gDepartment of Bacteriology, University of Bordeaux, France, \n        hFondation Fran\u00e7aise de Canc\u00e9rologie Dig"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Palazzo","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology, H\u00f4tel-Dieu, AP-HP, Paris, France, \n        bH\u00f4pital Lariboisi\u00e8re, Paris, France, \n        cDepartment of Pathology, H\u00f4pital Lariboisi\u00e8re, AP-HP, Paris, France, \n        dH\u00f4tel Dieu, AP-HP, Paris, France, \n        eDepartment of Biostatistics, H\u00f4pital Ambroise Par\u00e9, Boulogne, France, \n        fDepartment of Pathology, University of Bordeaux, France, \n        gDepartment of Bacteriology, University of Bordeaux, France, \n        hFondation Fran\u00e7aise de Canc\u00e9rologie Dig"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"de Mascarel","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology, H\u00f4tel-Dieu, AP-HP, Paris, France, \n        bH\u00f4pital Lariboisi\u00e8re, Paris, France, \n        cDepartment of Pathology, H\u00f4pital Lariboisi\u00e8re, AP-HP, Paris, France, \n        dH\u00f4tel Dieu, AP-HP, Paris, France, \n        eDepartment of Biostatistics, H\u00f4pital Ambroise Par\u00e9, Boulogne, France, \n        fDepartment of Pathology, University of Bordeaux, France, \n        gDepartment of Bacteriology, University of Bordeaux, France, \n        hFondation Fran\u00e7aise de Canc\u00e9rologie Dig"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Molina","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology, H\u00f4tel-Dieu, AP-HP, Paris, France, \n        bH\u00f4pital Lariboisi\u00e8re, Paris, France, \n        cDepartment of Pathology, H\u00f4pital Lariboisi\u00e8re, AP-HP, Paris, France, \n        dH\u00f4tel Dieu, AP-HP, Paris, France, \n        eDepartment of Biostatistics, H\u00f4pital Ambroise Par\u00e9, Boulogne, France, \n        fDepartment of Pathology, University of Bordeaux, France, \n        gDepartment of Bacteriology, University of Bordeaux, France, \n        hFondation Fran\u00e7aise de Canc\u00e9rologie Dig"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-C L","family":"Rambaud","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology, H\u00f4tel-Dieu, AP-HP, Paris, France, \n        bH\u00f4pital Lariboisi\u00e8re, Paris, France, \n        cDepartment of Pathology, H\u00f4pital Lariboisi\u00e8re, AP-HP, Paris, France, \n        dH\u00f4tel Dieu, AP-HP, Paris, France, \n        eDepartment of Biostatistics, H\u00f4pital Ambroise Par\u00e9, Boulogne, France, \n        fDepartment of Pathology, University of Bordeaux, France, \n        gDepartment of Bacteriology, University of Bordeaux, France, \n        hFondation Fran\u00e7aise de Canc\u00e9rologie Dig"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Groupe d'\u00c9tude des Lymphomes Digestifs (GELD\u2020\nh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2001,3,1]]},"reference":[{"key":"2025121223082968000_48.3.297.1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(94)90060-4"},{"key":"2025121223082968000_48.3.297.2","first-page":"575","volume":"342","author":"Wotherspoon","year":"1993","journal-title":", et al. Regression of primary low-grade B-cell lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori. Lancet"},{"key":"2025121223082968000_48.3.297.3","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91404-A"},{"key":"2025121223082968000_48.3.297.4","first-page":"1591","volume":"345","author":"Bayerd\u00f6rffer","year":"1995","journal-title":", et al. Lymphoma Study Group: regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure of Helicobacter pylori infection. Lancet"},{"key":"2025121223082968000_48.3.297.5","first-page":"767","volume":"122","author":"Roggero","year":"1995","journal-title":", et al. Eradication of Helicobacter pylori infection in primary low-grade gastric lymphoma of mucosa-associated lymphoid tissue. Ann Intern Med"},{"key":"2025121223082968000_48.3.297.6","first-page":"1255","volume":"87","author":"Savio","year":"1996","journal-title":", et al. Diagnosis and post-treatment follow-up of Helicobacter pylori positive gastric lymphoma of mucosa-associated lymphoid tissue: histology, polymerase chain reaction, or both? Blood"},{"key":"2025121223082968000_48.3.297.7","first-page":"1350","volume":"89","author":"Neubauer","year":"1997","journal-title":", et al. Cure of Helicobacter pylori infection and duration of remission of low-grade gastric mucosa-associated lymphoid tissue lymphoma. J Natl Cancer Inst"},{"key":"2025121223082968000_48.3.297.8","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/annonc\/8.suppl_2.S37","article-title":"Helicobacter pylori eradication for the treatment of low-grade gastric MALT lymphoma: follow-up together with sequential molecular studies.","volume":"8 (suppl 2)","author":"Montalban","year":"1997","journal-title":"Ann Oncol"},{"key":"2025121223082968000_48.3.297.9","first-page":"527","volume":"26","author":"Pinotti","year":"1997","journal-title":", et al. Clinical features, treatment and outcome in a series of 93 patients with low-grade gastric MALT lymphoma. Leukemia Lymphoma"},{"key":"2025121223082968000_48.3.297.10","first-page":"732","volume":"93","author":"Nobre-Leitao","year":"1998","journal-title":", et al. Treatment of gastric MALT lymphoma by Helicobacter pylori eradication: a study controlled by endoscopic ultrasonography. Am J Gastroenterol"},{"key":"2025121223082968000_48.3.297.11","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-131-2-199907200-00003"},{"key":"2025121223082968000_48.3.297.12","first-page":"784","volume":"29","author":"de Mascarel","year":"1998","journal-title":", et al. Low prevalence of monoclonal B cells in Helicobacter pylori gastritis patients with duodenal ulcer. Hum Pathol"},{"key":"2025121223082968000_48.3.297.13","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0016-5085(97)80020-0","article-title":"How should Helicobacter.pylori infection be diagnosed?","volume":"133","author":"Megraud","year":"1997","journal-title":"Gastroenterology"},{"key":"2025121223082968000_48.3.297.14","first-page":"502","volume":"25","author":"Palazzo","year":"1993","journal-title":", et al. Endoscopic ultrasonography in the local staging of primary gastric lymphoma. Endoscopy"},{"key":"2025121223082968000_48.3.297.15","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70101-5"},{"key":"2025121223082968000_48.3.297.16","first-page":"248","volume":"116","author":"Lindt","year":"1999","journal-title":", et al. The MACH2 study: role of omeprazole in eradication of Helicobacter pylori. Gastroenterology"},{"key":"2025121223082968000_48.3.297.17","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4"},{"key":"2025121223082968000_48.3.297.18","first-page":"1104","volume":"15","author":"Rudolph","year":"1997","journal-title":", et al. Is the polymerase chain reaction or cure of Helicobacter pylori infection of help in the differential diagnosis of early gastric mucosa-associated lymphatic tissue lymphoma? J Clin Oncol"},{"key":"2025121223082968000_48.3.297.19","first-page":"1466","volume":"112","author":"De Jong","year":"1997","journal-title":", et al. Histological grading in gastric lymphoma: pretreatment criteria and clinical relevance. Gastroenterology"},{"key":"2025121223082968000_48.3.297.20","first-page":"448","volume":"346","author":"Boot","year":"1995","journal-title":", et al. Role of Helicobacter pylori eradication in high-grade MALT lymphoma. Lancet"},{"key":"2025121223082968000_48.3.297.21","first-page":"556","volume":"39","author":"Taal","year":"1996","journal-title":", et al. Primary non-Hodgkin lymphoma of the stomach: endoscopic pattern and prognosis in low versus high-grade malignancy in relation to the MALT concept. Gut"},{"key":"2025121223082968000_48.3.297.22","first-page":"3","volume":"79","author":"Nakamura","year":"1997","journal-title":", et al. Helicobacter pylori and primary gastric lymphoma. Cancer"},{"key":"2025121223082968000_48.3.297.23","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/S0344-0338(11)80904-0","article-title":"Factors influencing lymph node infiltration in primary malignant lymphoma of the mucosa-associated lymphoid tissue.","volume":"190","author":"Eidt","year":"1994","journal-title":"Pathol Res Pract"},{"key":"2025121223082968000_48.3.297.24","first-page":"1087","volume":"113","author":"Sackman","year":"1997","journal-title":", et al. Regression of primary gastric low-grade MALT lymphoma after cure of Helicobacter pylori infection is predicted by endosonographic staging. Gastroenterology"},{"key":"2025121223082968000_48.3.297.25","doi-asserted-by":"crossref","unstructured":"Isaacson PG Diss T Wotherspoon A (1999) Long term follow-up of gastric MALT lymphoma treated by eradication of H. pylori with antibiotics. Lancet 117, ,750\u201351.","DOI":"10.1016\/S0016-5085(99)70483-X"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.48.3.297","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:08:39Z","timestamp":1765609719000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.48.3.297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,3,1]]},"references-count":25,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2001,3,1]]},"published-print":{"date-parts":[[2001,3,1]]}},"alternative-id":["10.1136\/gut.48.3.297"],"URL":"https:\/\/doi.org\/10.1136\/gut.48.3.297","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,3,1]]}}}