{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T22:31:07Z","timestamp":1774305067956,"version":"3.50.1"},"reference-count":33,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[2000,8,8]]},"published-print":{"date-parts":[[2001,3,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND\/AIMS<\/jats:title>\n                    <jats:p>Cryptogenetic multifocal ulcerous stenosing enteritis (CMUSE) is a rare disease whose origin is unknown. The aim of this study was to describe the clinical spectrum of CMUSE, to determine the origin and pathophysiology of the disease, and to propose a treatment strategy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"methods\">\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A total of 220 French gastroenterology departments were contacted to review patients with unexplained small bowel strictures. Of 17 responses, 12 corresponded to a diagnosis of CMUSE. These patients were hospitalised between 1965 and 1993 and their medical records were reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>All patients (mean age 42.1 (4.4) years) had intestinal and five had extraintestinal symptoms (peripheral neuropathy, buccal aphthae, sicca syndrome, polyarthralgia, Raynaud's phenomenon, arterial hypertension). One patient had heterozygous type I C2 deficiency (28 base pair gene deletion). Two to 25 (mean 8.3 (1.9)) small intestine strictures were found. Stenoses of the large jejunoileal arteries were observed on two and aneurysms on three of five mesenteric angiograms. Despite surgery, symptoms recurred in seven of 10 patients and strictures in four. Steroid therapy was effective but caused dependence. One untreated patient died. Small bowel pathology showed superficial ulceration of the mucosae and submucosae, and an inflammatory infiltrate made of neutrophils and eosinophils.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>CMUSE is an independent entity characterised by steroid sensitive inflammation of the small bowel which often recurs after surgery. CMUSE may be related to a particular form of polyarteritis nodosa with mainly intestinal expression or with an as yet unclassified vasculitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gut.48.3.333","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:32:32Z","timestamp":1027751552000},"page":"333-338","source":"Crossref","is-referenced-by-count":76,"title":["Cryptogenetic multifocal ulcerous stenosing enteritis: an atypical type of vasculitis or a disease mimicking vasculitis"],"prefix":"10.1136","volume":"48","author":[{"given":"G","family":"Perlemuter","sequence":"first","affiliation":[{"name":"aService d'H\u00e9pato-gastroent\u00e9rologie, H\u00f4pital de Bic\u00eatre, 78, rue du G\u00e9n\u00e9ral Leclerc, 94275 Le Kremlin Bic\u00eatre, France, \n        bService de M\u00e9decine Interne, H\u00f4pital Avicenne, 125, route de Stalingrad, 93009 Bobigny, France, \n        cService de Radiologie A, H\u00f4pital Cochin, 27, rue du Faubourg Saint-Jacques, 75679 Paris Cedex 14, France, \n        dService d'Immunologie Clinique, H\u00f4pital Europ\u00e9en Georges Pompidou, 20, rue Leblanc, 75015 Paris, France, \n        eService d'H\u00e9pato-gastroent\u00e9rologie, H"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Guillevin","sequence":"additional","affiliation":[{"name":"aService d'H\u00e9pato-gastroent\u00e9rologie, H\u00f4pital de Bic\u00eatre, 78, rue du G\u00e9n\u00e9ral Leclerc, 94275 Le Kremlin Bic\u00eatre, France, \n        bService de M\u00e9decine Interne, H\u00f4pital Avicenne, 125, route de Stalingrad, 93009 Bobigny, France, \n        cService de Radiologie A, H\u00f4pital Cochin, 27, rue du Faubourg Saint-Jacques, 75679 Paris Cedex 14, France, \n        dService d'Immunologie Clinique, H\u00f4pital Europ\u00e9en Georges Pompidou, 20, rue Leblanc, 75015 Paris, France, \n        eService d'H\u00e9pato-gastroent\u00e9rologie, H"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Legman","sequence":"additional","affiliation":[{"name":"aService d'H\u00e9pato-gastroent\u00e9rologie, H\u00f4pital de Bic\u00eatre, 78, rue du G\u00e9n\u00e9ral Leclerc, 94275 Le Kremlin Bic\u00eatre, France, \n        bService de M\u00e9decine Interne, H\u00f4pital Avicenne, 125, route de Stalingrad, 93009 Bobigny, France, \n        cService de Radiologie A, H\u00f4pital Cochin, 27, rue du Faubourg Saint-Jacques, 75679 Paris Cedex 14, France, \n        dService d'Immunologie Clinique, H\u00f4pital Europ\u00e9en Georges Pompidou, 20, rue Leblanc, 75015 Paris, France, \n        eService d'H\u00e9pato-gastroent\u00e9rologie, H"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Weiss","sequence":"additional","affiliation":[{"name":"aService d'H\u00e9pato-gastroent\u00e9rologie, H\u00f4pital de Bic\u00eatre, 78, rue du G\u00e9n\u00e9ral Leclerc, 94275 Le Kremlin Bic\u00eatre, France, \n        bService de M\u00e9decine Interne, H\u00f4pital Avicenne, 125, route de Stalingrad, 93009 Bobigny, France, \n        cService de Radiologie A, H\u00f4pital Cochin, 27, rue du Faubourg Saint-Jacques, 75679 Paris Cedex 14, France, \n        dService d'Immunologie Clinique, H\u00f4pital Europ\u00e9en Georges Pompidou, 20, rue Leblanc, 75015 Paris, France, \n        eService d'H\u00e9pato-gastroent\u00e9rologie, H"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Couturier","sequence":"additional","affiliation":[{"name":"aService d'H\u00e9pato-gastroent\u00e9rologie, H\u00f4pital de Bic\u00eatre, 78, rue du G\u00e9n\u00e9ral Leclerc, 94275 Le Kremlin Bic\u00eatre, France, \n        bService de M\u00e9decine Interne, H\u00f4pital Avicenne, 125, route de Stalingrad, 93009 Bobigny, France, \n        cService de Radiologie A, H\u00f4pital Cochin, 27, rue du Faubourg Saint-Jacques, 75679 Paris Cedex 14, France, \n        dService d'Immunologie Clinique, H\u00f4pital Europ\u00e9en Georges Pompidou, 20, rue Leblanc, 75015 Paris, France, \n        eService d'H\u00e9pato-gastroent\u00e9rologie, H"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Chaussade","sequence":"additional","affiliation":[{"name":"aService d'H\u00e9pato-gastroent\u00e9rologie, H\u00f4pital de Bic\u00eatre, 78, rue du G\u00e9n\u00e9ral Leclerc, 94275 Le Kremlin Bic\u00eatre, France, \n        bService de M\u00e9decine Interne, H\u00f4pital Avicenne, 125, route de Stalingrad, 93009 Bobigny, France, \n        cService de Radiologie A, H\u00f4pital Cochin, 27, rue du Faubourg Saint-Jacques, 75679 Paris Cedex 14, France, \n        dService d'Immunologie Clinique, H\u00f4pital Europ\u00e9en Georges Pompidou, 20, rue Leblanc, 75015 Paris, France, \n        eService d'H\u00e9pato-gastroent\u00e9rologie, H"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2001,3,1]]},"reference":[{"key":"2025121309572789000_48.3.333.1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(68)90236-2"},{"key":"2025121309572789000_48.3.333.2","first-page":"193","article-title":"Ent\u00e9rite st\u00e9nosante ulc\u00e9reuse plurifocale cryptog\u00e9n\u00e9tique.","volume":"53","author":"Debray","year":"1964","journal-title":"Arch Fr Mal App Dig"},{"key":"2025121309572789000_48.3.333.3","first-page":"1230","article-title":"La maladie ulc\u00e9reuse st\u00e9nosante du j\u00e9juno-il\u00e9on.","volume":"10","author":"Rocha","year":"1959","journal-title":"Arch Fr Mal App Dig"},{"key":"2025121309572789000_48.3.333.4","first-page":"31","article-title":"St\u00e9noses multiples \u201cidiopathiques\u201d de l'intestin gr\u00eale. 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(A propos d'une nouvelle observation).","volume":"14","author":"Lescut","year":"1969","journal-title":"Lille Med"},{"key":"2025121309572789000_48.3.333.8","first-page":"808","article-title":"L'ent\u00e9rite st\u00e9nosante ulc\u00e9reuse multifocale cryptog\u00e9n\u00e9tique: une entit\u00e9 autonome?","volume":"8","author":"Chagnon","year":"1984","journal-title":"Gastroenterol Clin Biol"},{"key":"2025121309572789000_48.3.333.9","first-page":"537","article-title":"Ent\u00e9rite st\u00e9nosante ulc\u00e9reuse plurifocale. 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Clinical, pathologic, immunologic, and therapeutic considerations.","volume":"89","author":"Fauci","year":"1978","journal-title":"Ann Intern Med"},{"key":"2025121309572789000_48.3.333.23","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/0016-5085(88)90363-0","article-title":"Scintigraphic assessment of bowel involvement and disease activity in Crohn's disease using technetium 99m-hexamethyl propylene amine oxine as leukocyte label.","volume":"95","author":"Sch\u00f6lmerich","year":"1988","journal-title":"Gastroenterology"},{"key":"2025121309572789000_48.3.333.24","first-page":"83","article-title":"Vasculitis, 1815 to 1991: classification and diagnostic specificity.","volume":"19","author":"Lie","year":"1992","journal-title":"J Rheumatol"},{"key":"2025121309572789000_48.3.333.25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00005792-197801000-00001","article-title":"Complement deficiency states.","volume":"57","author":"Agnello","year":"1978","journal-title":"Medicine"},{"key":"2025121309572789000_48.3.333.26","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0016-5107(92)70487-8","article-title":"Polyarteritis nodosa of the gastrointestinal tract with endoscopically documented duodenal and jejunal ulceration.","volume":"38","author":"Williams","year":"1992","journal-title":"Gastrointest Endosc"},{"key":"2025121309572789000_48.3.333.27","first-page":"104","article-title":"Surgical aspects of systemic necrotizing vasculitis.","volume":"97","author":"McCauley","year":"1985","journal-title":"Surgery"},{"key":"2025121309572789000_48.3.333.28","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1148\/radiology.184.1.1609082","article-title":"Small bowel stricture caused by rheumatoid vasculitis.","volume":"184","author":"Kuehne","year":"1992","journal-title":"Radiology"},{"key":"2025121309572789000_48.3.333.29","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1177\/028418519103200212","article-title":"Diagnostic significance of angiographically observed visceral aneurysm with regard to polyarteritis nodosa.","volume":"32","author":"Herali","year":"1991","journal-title":"Acta Radiol"},{"key":"2025121309572789000_48.3.333.30","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1002\/art.1780330805","article-title":"The American College of Rheumatology 1990 criteria for the classification of polyarteritis nodosa.","volume":"33","author":"Lightfoot","year":"1990","journal-title":"Arthritis Rheum"},{"key":"2025121309572789000_48.3.333.31","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0016-5107(92)70487-8","article-title":"Polyarteritis nodosa of the gastrointestinal tract with endoscopically documented duodenal and jejunal ulceration.","volume":"38","author":"Williams","year":"1992","journal-title":"Gastrointest Endosc"},{"key":"2025121309572789000_48.3.333.32","first-page":"677","article-title":"Gastrointestinal involvement in leukocytoclastic vasculitis and polyarteritis nodosa.","volume":"5","author":"Lopez","year":"1980","journal-title":"J Rheumatol"},{"key":"2025121309572789000_48.3.333.33","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370206"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.48.3.333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T17:57:35Z","timestamp":1765648655000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.48.3.333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,3,1]]},"references-count":33,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2001,3,1]]},"published-print":{"date-parts":[[2001,3,1]]}},"alternative-id":["10.1136\/gut.48.3.333"],"URL":"https:\/\/doi.org\/10.1136\/gut.48.3.333","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,3,1]]}}}