{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T21:17:39Z","timestamp":1770499059136,"version":"3.49.0"},"reference-count":28,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[2000,10,31]]},"published-print":{"date-parts":[[2001,3,1]]},"abstract":"<jats:p>\n                    Coeliac disease (CD) is caused by a CD4  T helper cell type 1 (Th1) response in the small intestinal mucosa to dietary gluten. As the major Th1 inducing cytokine, interleukin 12, is undetectable in CD gut mucosa, the mechanism by which Th1 effector cells are generated remains unknown. Interferon (IFN) \u03b1, a cytokine capable of promoting IFN-\u03b3 synthesis, has been implicated in the development of Th1 mediated immune diseases. Here we report a case of CD-like enteropathy in a patient receiving IFN-\u03b1 for chronic myeloid leukaemia. Morphological assessment of duodenal biopsies taken from the patient showed total villous atrophy, crypt cell hyperplasia, and a high number of CD3\n                    <jats:sup>+<\/jats:sup>\n                    intraepithelial lymphocytes. Both antigliadin antibodies and antiendomysial antibodies were positive. RNA analysis revealed pronounced expression of IFN-\u03b3. Withdrawal of gluten from the diet resulted in a patchy improvement in intestinal morphology, normalisation of laboratory parameters, and resolution of clinical symptoms. By western blot analysis, IFN-\u03b1 protein was seen in the duodenal mucosa from untreated CD patients but not in controls. This was associated with marked expression of IFN-\u03b3 protein in CD mucosa. Collectively, these results suggest a role for IFN-\u03b1 in promoting Th1 responses to gluten.\n                  <\/jats:p>","DOI":"10.1136\/gut.48.3.425","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:32:32Z","timestamp":1027751552000},"page":"425-429","source":"Crossref","is-referenced-by-count":111,"title":["Role of interferon \u03b1 in promoting T helper cell type 1 responses in the small intestine in coeliac disease"],"prefix":"10.1136","volume":"48","author":[{"given":"G","family":"Monteleone","sequence":"first","affiliation":[{"name":"aDivision of Infection, Allergy, Inflammation, and Repair, University of Southampton, School of Medicine, Southampton General Hospital, Southampton, UK, \n        bDigestive Diseases Research Centre, St Bartholomew's and the Royal London School of Medicine and Dentistry, London, UK, \n        cUniversitatsklinik fur Kinder und Jugenheilkunde, Karl-Franzens- Universitat, Graz, Austria, \n        dDipartimento di Pediatria, Universita' di Firenze, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S L F","family":"Pender","sequence":"additional","affiliation":[{"name":"aDivision of Infection, Allergy, Inflammation, and Repair, University of Southampton, School of Medicine, Southampton General Hospital, Southampton, UK, \n        bDigestive Diseases Research Centre, St Bartholomew's and the Royal London School of Medicine and Dentistry, London, UK, \n        cUniversitatsklinik fur Kinder und Jugenheilkunde, Karl-Franzens- Universitat, Graz, Austria, \n        dDipartimento di Pediatria, Universita' di Firenze, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Alstead","sequence":"additional","affiliation":[{"name":"aDivision of Infection, Allergy, Inflammation, and Repair, University of Southampton, School of Medicine, Southampton General Hospital, Southampton, UK, \n        bDigestive Diseases Research Centre, St Bartholomew's and the Royal London School of Medicine and Dentistry, London, UK, \n        cUniversitatsklinik fur Kinder und Jugenheilkunde, Karl-Franzens- Universitat, Graz, Austria, \n        dDipartimento di Pediatria, Universita' di Firenze, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A C","family":"Hauer","sequence":"additional","affiliation":[{"name":"aDivision of Infection, Allergy, Inflammation, and Repair, University of Southampton, School of Medicine, Southampton General Hospital, Southampton, UK, \n        bDigestive Diseases Research Centre, St Bartholomew's and the Royal London School of Medicine and Dentistry, London, UK, \n        cUniversitatsklinik fur Kinder und Jugenheilkunde, Karl-Franzens- Universitat, Graz, Austria, \n        dDipartimento di Pediatria, Universita' di Firenze, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Lionetti","sequence":"additional","affiliation":[{"name":"aDivision of Infection, Allergy, Inflammation, and Repair, University of Southampton, School of Medicine, Southampton General Hospital, Southampton, UK, \n        bDigestive Diseases Research Centre, St Bartholomew's and the Royal London School of Medicine and Dentistry, London, UK, \n        cUniversitatsklinik fur Kinder und Jugenheilkunde, Karl-Franzens- Universitat, Graz, Austria, \n        dDipartimento di Pediatria, Universita' di Firenze, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T T","family":"MacDonald","sequence":"additional","affiliation":[{"name":"aDivision of Infection, Allergy, Inflammation, and Repair, University of Southampton, School of Medicine, Southampton General Hospital, Southampton, UK, \n        bDigestive Diseases Research Centre, St Bartholomew's and the Royal London School of Medicine and Dentistry, London, UK, \n        cUniversitatsklinik fur Kinder und Jugenheilkunde, Karl-Franzens- Universitat, Graz, Austria, \n        dDipartimento di Pediatria, Universita' di Firenze, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2001,3,1]]},"reference":[{"key":"2025121220072107000_48.3.425.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70382-8"},{"key":"2025121220072107000_48.3.425.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(99)01536-4"},{"key":"2025121220072107000_48.3.425.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70134-9"},{"key":"2025121220072107000_48.3.425.4","doi-asserted-by":"publisher","DOI":"10.1007\/BF02090378"},{"key":"2025121220072107000_48.3.425.5","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0016-5085(93)90710-T","article-title":"T-cell activation can induce either mucosal destruction or adaptation in 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