{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:39:50Z","timestamp":1787017190153,"version":"build-2736575974"},"reference-count":33,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[2000,10,3]]},"published-print":{"date-parts":[[2001,4,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      While a close association between gastric mucosa associated lymphoid tissue (MALT) lymphoma and\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      infection has been established, there are still cases which do not respond to\n                      <jats:italic>H pylori<\/jats:italic>\n                      eradication.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>AIMS<\/jats:title>\n                    <jats:p>\n                      To investigate the clinicopathological factors which may help predict the therapeutic efficacy of\n                      <jats:italic>H pylori<\/jats:italic>\n                      eradication in gastric MALT lymphoma.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PATIENTS<\/jats:title>\n                    <jats:p>Forty one patients with gastric MALT lymphoma, including low and high grade lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"methods\">\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      After endosonographic staging was determined,\n                      <jats:italic>H pylori<\/jats:italic>\n                      was eradicated in all patients, and the subsequent gastric pathological course was then investigated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Complete regression of MALT lymphoma was observed in 29(71%) patients, partial regression in five (12%), and no regression in seven (17%). Twenty six (93%) of 28 MALT lymphomas restricted to the mucosa but only three (23%) of 13 lymphomas which invaded the deep portion of the submucosa or beyond completely regressed. Kaplan-Meier analysis for the probability of complete regression of MALT lymphoma revealed a significant difference between tumours restricted to the mucosa and those invading the submucosa deeply or beyond (p&lt;0.05). Neither the presence of a high grade component, perigastric lymphadenopathy, nor clinical staging prior to eradication correlated with the probability of lymphoma regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      Assessment of deep submucosal invasion by endosonography is valuable for predicting the efficacy of\n                      <jats:italic>H pylori<\/jats:italic>\n                      eradication in gastric MALT lymphoma.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gut.48.4.454","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:32:32Z","timestamp":1027751552000},"page":"454-460","source":"Crossref","is-referenced-by-count":188,"title":["Predictive value of endoscopic ultrasonography for regression of gastric low grade and high grade MALT lymphomas after eradication of\n                    <i>Helicobacter pylori<\/i>"],"prefix":"10.1136","volume":"48","author":[{"given":"S","family":"Nakamura","sequence":"first","affiliation":[{"name":"aSecond Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan, \n\nbDivision of Gastroenterology, Department of Medicine, Kawasaki Medical School, Kurashiki, Japan, \n\ncDivision of Pathology, National Kyushu Medical Center, Fukuoka, Japan, \n\ndSecond Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"aSecond Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan, \n\nbDivision of Gastroenterology, Department of Medicine, Kawasaki Medical School, Kurashiki, Japan, \n\ncDivision of Pathology, National Kyushu Medical Center, Fukuoka, Japan, \n\ndSecond Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Suekane","sequence":"additional","affiliation":[{"name":"aSecond Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan, \n\nbDivision of Gastroenterology, Department of Medicine, Kawasaki Medical School, Kurashiki, Japan, \n\ncDivision of Pathology, National Kyushu Medical Center, Fukuoka, Japan, \n\ndSecond Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Takeshita","sequence":"additional","affiliation":[{"name":"aSecond Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan, \n\nbDivision of Gastroenterology, Department of Medicine, Kawasaki Medical School, Kurashiki, Japan, \n\ncDivision of Pathology, National Kyushu Medical Center, Fukuoka, Japan, \n\ndSecond Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Hizawa","sequence":"additional","affiliation":[{"name":"aSecond Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan, \n\nbDivision of Gastroenterology, Department of Medicine, Kawasaki Medical School, Kurashiki, Japan, \n\ncDivision of Pathology, National Kyushu Medical Center, Fukuoka, Japan, \n\ndSecond Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"aSecond Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan, \n\nbDivision of Gastroenterology, Department of Medicine, Kawasaki Medical School, Kurashiki, Japan, \n\ncDivision of Pathology, National Kyushu Medical Center, Fukuoka, Japan, \n\ndSecond Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Yao","sequence":"additional","affiliation":[{"name":"aSecond Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan, \n\nbDivision of Gastroenterology, Department of Medicine, Kawasaki Medical School, Kurashiki, Japan, \n\ncDivision of Pathology, National Kyushu Medical Center, Fukuoka, Japan, \n\ndSecond Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Tsuneyoshi","sequence":"additional","affiliation":[{"name":"aSecond Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan, \n\nbDivision of Gastroenterology, Department of Medicine, Kawasaki Medical School, Kurashiki, Japan, \n\ncDivision of Pathology, National Kyushu Medical Center, Fukuoka, Japan, \n\ndSecond 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