{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:57:23Z","timestamp":1792195043947,"version":"4.4.0"},"reference-count":29,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[2000,11,14]]},"published-print":{"date-parts":[[2001,5,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND AND AIMS<\/jats:title>\n                    <jats:p>\n                      We previously reported the effect of\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      eradication on hyperammonaemia in patients with liver cirrhosis. However, the role of\n                      <jats:italic>H pylori<\/jats:italic>\n                      as a cause of hyperammonaemia is controversial. We developed an animal model with liver cirrhosis and investigated the effect of\n                      <jats:italic>H pylori<\/jats:italic>\n                      infection on hyperammonaemia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIALS AND METHODS<\/jats:title>\n                    <jats:p>\n                      Five week old male Mongolian gerbils were inoculated orally with broth culture of\n                      <jats:italic>H pylori<\/jats:italic>\n                      . Forty eight gerbils were divided into four groups. Gerbils not inoculated with\n                      <jats:italic>H pylori<\/jats:italic>\n                      were fed a commercial rodent diet (group A) or a choline deficient diet (group C). Gerbils inoculated with\n                      <jats:italic>H pylori<\/jats:italic>\n                      were fed the commercial rodent diet (group B) or the choline deficient diet (group D). Blood ammonia levels of the femoral vein and portal vein were measured 30 weeks later.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>All gerbils fed the choline deficient diet developed liver cirrhosis with fatty metamorphosis. The survival rate of group D was significantly lower than that of the other groups. Systemic and portal blood ammonia levels in group D were significantly higher than those in the other groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      <jats:italic>H pylori<\/jats:italic>\n                      infection induces hyperammonaemia in gerbils with liver cirrhosis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gut.48.5.605","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:32:32Z","timestamp":1027751552000},"page":"605-608","source":"Crossref","is-referenced-by-count":9,"title":["<i>Helicobacter pylori<\/i>\n                    infection induces hyperammonaemia in Mongolian gerbils with liver cirrhosis"],"prefix":"10.1136","volume":"48","author":[{"given":"H","family":"Suto","sequence":"first","affiliation":[{"name":"aSecond Department of Internal Medicine, Faculty of Medicine, Fukui Medical University, Fukui, Japan, \n\nbDepartment of Internal Medicine, Aiseikai Yamashina Hospital, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Azuma","sequence":"additional","affiliation":[{"name":"aSecond Department of Internal Medicine, Faculty of Medicine, Fukui Medical University, Fukui, Japan, \n\nbDepartment of Internal Medicine, Aiseikai Yamashina Hospital, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Ito","sequence":"additional","affiliation":[{"name":"aSecond Department of Internal Medicine, Faculty of Medicine, Fukui Medical University, Fukui, Japan, \n\nbDepartment of Internal Medicine, Aiseikai Yamashina Hospital, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Ohtani","sequence":"additional","affiliation":[{"name":"aSecond Department of Internal Medicine, Faculty of Medicine, Fukui Medical University, Fukui, Japan, \n\nbDepartment of Internal Medicine, Aiseikai Yamashina Hospital, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Dojo","sequence":"additional","affiliation":[{"name":"aSecond Department of Internal Medicine, Faculty of Medicine, Fukui Medical University, Fukui, Japan, \n\nbDepartment of Internal Medicine, Aiseikai Yamashina Hospital, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Ito","sequence":"additional","affiliation":[{"name":"aSecond Department of Internal Medicine, Faculty of Medicine, Fukui Medical University, Fukui, Japan, \n\nbDepartment of Internal Medicine, Aiseikai Yamashina Hospital, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Kohli","sequence":"additional","affiliation":[{"name":"aSecond Department of Internal Medicine, Faculty of Medicine, Fukui Medical University, Fukui, Japan, \n\nbDepartment of Internal Medicine, Aiseikai 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