{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:18:02Z","timestamp":1779211082527,"version":"3.51.4"},"reference-count":29,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[2000,12,5]]},"published-print":{"date-parts":[[2001,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      infection is less prevalent and atrophic gastritis is less extensive in patients with reflux oesophagitis than those without it, but few studies have examined this relationship directly.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>AIMS<\/jats:title>\n                    <jats:p>\n                      We investigated the relationship between\n                      <jats:italic>H pylori<\/jats:italic>\n                      infection, acid secretion, and reflux oesophagitis in Japanese subjects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SUBJECTS<\/jats:title>\n                    <jats:p>A total of 105 patients with erosive reflux oesophagitis were compared with 105 sex and age matched patients without reflux oesophagitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec sec-type=\"methods\">\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      The diagnosis of\n                      <jats:italic>H pylori<\/jats:italic>\n                      infection was made by histological examination of gastric mucosal biopsy specimens, rapid urease test, and detection of serum IgG antibodies. Acid secretion was assessed by the endoscopic gastrin test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      <jats:italic>H pylori<\/jats:italic>\n                      infection was present in 36 patients with erosive reflux oesophagitis (34.3%) and in 80 control subjects (76.2%) (odds ratio 0.163, 95% confidence interval 0.09\u20130.29). Overall acid secretion was significantly greater in patients with reflux oesophagitis. Among\n                      <jats:italic>H pylori<\/jats:italic>\n                      positive patients, acid secretion was greater in patients with reflux oesophagitis than those without oesophagitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      In Japan, erosive reflux oesophagitis occurs most often in the absence of\n                      <jats:italic>H pylori<\/jats:italic>\n                      infection and gastric hyposecretion. Even in the presence of\n                      <jats:italic>H pylori<\/jats:italic>\n                      infection, reflux oesophagitis is more likely to develop in patients without gastric hyposecretion.\n                      <jats:italic>H pylori<\/jats:italic>\n                      infection may inhibit reflux oesophagitis by inducing hypoacidity.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gut.49.3.330","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:37:59Z","timestamp":1027751879000},"page":"330-334","source":"Crossref","is-referenced-by-count":152,"title":["<i>Helicobacter pylori<\/i>\n                    infection prevents erosive reflux oesophagitis by decreasing gastric acid secretion"],"prefix":"10.1136","volume":"49","author":[{"given":"T","family":"Koike","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8574, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Ohara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8574, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Sekine","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8574, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Iijima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8574, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8574, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8574, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Toyota","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8574, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Shimosegawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8574, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2001,9,1]]},"reference":[{"key":"2025121306473210000_49.3.330.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198212163072503"},{"key":"2025121306473210000_49.3.330.2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.29.8.1020"},{"key":"2025121306473210000_49.3.330.3","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(86)90692-X"},{"key":"2025121306473210000_49.3.330.4","doi-asserted-by":"publisher","DOI":"10.1007\/BF01324902"},{"key":"2025121306473210000_49.3.330.5","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/0016-5085(92)90156-S","article-title":"et al. 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