{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T19:52:45Z","timestamp":1757620365074,"version":"3.44.0"},"reference-count":26,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[2001,2,26]]},"published-print":{"date-parts":[[2001,9,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND AND AIMS<\/jats:title>\n                  <jats:p>It has been shown that gastro-oesophageal reflux plays a role in the pathogenesis of intestinal metaplasia (IM) limited to the oesophagogastric junction (OGJ), similar to the pathogenesis of IM in long segments of columnar lined oesophagus. The aim of this study was to examine lower oesophageal sphincter (LOS) function by means of prolonged recording in patients with IM limited to a normal appearing OGJ.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>PATIENTS AND METHODS<\/jats:title>\n                  <jats:p>Eighteen patients with IM at the OGJ (five females, 13 males; mean age 55.4 years) and 22 patients without IM (nine females, 13 males; mean age 53.9 years) underwent conventional stationary oesophageal manometry. Thereafter, seven hour water perfused manometry with simultaneous pH measurement (probe 5 cm proximal to the LOS) was performed. Swallowing was monitored with a pharyngeal sidehole and LOS pressure was recorded with a Dent sleeve. Patients were studied in the fasted state (three hours) and after a standardised meal (four hours). LOS pressure was analysed using customised software, and the incidence of reflux episodes (pH &lt;4 for at least five seconds) and transient LOS relaxations (TLOSRs) were examined. TLOSRs were judged to be accompanied by reflux if a decrease of 1 pH unit occurred during relaxation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Patients with IM at the OGJ had a higher prevalence of postprandial acid reflux compared with patients without IM. No differences were observed in LOS pressure (pre- and postprandially) or in the prevalence of TLOSRs. However, in the postprandial phase, the rate of TLOSRs accompanied by acid reflux was increased in patients with IM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSION<\/jats:title>\n                  <jats:p>Patients with IM at the OGJ have a higher prevalence of postprandial acid reflux. This is not associated with a higher prevalence of TLOSRs or a decreased LOS pressure but with a higher rate of TLOSRs accompanied by reflux.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/gut.49.3.354","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:37:59Z","timestamp":1027751879000},"page":"354-358","source":"Crossref","is-referenced-by-count":4,"title":["Prolonged measurement of lower oesophageal sphincter function in patients with intestinal metaplasia at the oesophagogastric junction"],"prefix":"10.1136","volume":"49","author":[{"given":"C","family":"Wolf","sequence":"first","affiliation":[{"name":"aDepartment of Gastroenterology, St Antonius Hospital Nieuwegein, the Netherlands, \n\nbDepartment of Gastroenterology, Diakonessenhuis Utrecht, the Netherlands, \n\ncDepartment of Pathology, St Antonius Hospital Nieuwegein, the Netherlands, \n\ndGastrointestinal Research Unit, Departments of Gastroenterology and Surgery, University Medical Centre, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Timmer","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology, St Antonius Hospital Nieuwegein, the Netherlands, \n\nbDepartment of Gastroenterology, Diakonessenhuis Utrecht, the Netherlands, \n\ncDepartment of Pathology, St Antonius Hospital Nieuwegein, the Netherlands, \n\ndGastrointestinal Research Unit, Departments of Gastroenterology and Surgery, University Medical Centre, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Breumelhof","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology, St Antonius Hospital Nieuwegein, the Netherlands, \n\nbDepartment of Gastroenterology, Diakonessenhuis Utrecht, the Netherlands, \n\ncDepartment of Pathology, St Antonius Hospital Nieuwegein, the Netherlands, \n\ndGastrointestinal Research Unit, Departments of Gastroenterology and Surgery, University Medical Centre, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C A","family":"Seldenrijk","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology, St Antonius Hospital Nieuwegein, the Netherlands, \n\nbDepartment of Gastroenterology, Diakonessenhuis Utrecht, the Netherlands, \n\ncDepartment of Pathology, St Antonius Hospital Nieuwegein, the Netherlands, \n\ndGastrointestinal Research Unit, Departments of Gastroenterology and Surgery, University Medical Centre, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A J P M","family":"Smout","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology, St Antonius Hospital Nieuwegein, the Netherlands, \n\nbDepartment of Gastroenterology, Diakonessenhuis Utrecht, the Netherlands, \n\ncDepartment of Pathology, St Antonius Hospital Nieuwegein, the Netherlands, \n\ndGastrointestinal Research Unit, Departments of Gastroenterology and Surgery, University Medical Centre, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2001,9,1]]},"reference":[{"key":"2025090723021334000_49.3.354.1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01308357"},{"key":"2025090723021334000_49.3.354.2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(94)90057-4"},{"key":"2025090723021334000_49.3.354.3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03460100089030"},{"key":"2025090723021334000_49.3.354.4","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/0016-5085(93)90420-H","article-title":"Increasing incidence of adenocarcinoma of the esophagus and esophagogastric junction.","volume":"104","author":"Pera","year":"1993","journal-title":"Gastroenterology"},{"key":"2025090723021334000_49.3.354.5","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1111\/j.1572-0241.1998.00276.x","article-title":"Esophageal manometry and ambulatory 24-hour pH monitoring in patients with short and long segment Barrett's esophagus.","volume":"93","author":"Loughney","year":"1998","journal-title":"Am J Gastroenterol"},{"key":"2025090723021334000_49.3.354.6","doi-asserted-by":"publisher","DOI":"10.1016\/S1091-255X(97)80098-4"},{"key":"2025090723021334000_49.3.354.7","doi-asserted-by":"publisher","DOI":"10.1016\/S1091-255X(98)80055-3"},{"key":"2025090723021334000_49.3.354.8","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199710000-00013"},{"key":"2025090723021334000_49.3.354.9","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1172\/JCI109667","article-title":"Mechanism of gastroesophageal reflux in recumbent asymptomatic human subjects.","volume":"65","author":"Dent","year":"1980","journal-title":"J Clin Invest"},{"key":"2025090723021334000_49.3.354.10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198212163072503"},{"key":"2025090723021334000_49.3.354.11","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90351-8"},{"key":"2025090723021334000_49.3.354.12","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.1998.00093.x"},{"key":"2025090723021334000_49.3.354.13","first-page":"A72","article-title":"24-h ambulatory LOS pressure recording using a portable water-perfused manometric system and fully automated signal analysis.","volume":"10","author":"van Herwaarden","year":"1998","journal-title":"Neurogastroenterol Motil"},{"key":"2025090723021334000_49.3.354.14","doi-asserted-by":"publisher","DOI":"10.1007\/BF01297443"},{"key":"2025090723021334000_49.3.354.15","first-page":"G128","article-title":"Criteria for objective definition of transient lower esophageal sphincter relaxation.","volume":"268","author":"Holloway","year":"1995","journal-title":"Am J Physiol"},{"key":"2025090723021334000_49.3.354.16","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0022-5223(19)33854-1","article-title":"Functional foregut abnormalities in Barrett's esophagus.","volume":"105","author":"Stein","year":"1993","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2025090723021334000_49.3.354.17","first-page":"349","article-title":"Esophageal motor dysfunction and acid exposure in reflux esophagitis are more severe if Barrett's metaplasia is present.","volume":"89","author":"Singh","year":"1994","journal-title":"Am J Gastroenterol"},{"key":"2025090723021334000_49.3.354.18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00331.x"},{"key":"2025090723021334000_49.3.354.19","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0889-8553(21)00590-2","article-title":"Barrett's esophagus and esophageal adenocarcinoma.","volume":"20","author":"Reid","year":"1991","journal-title":"Gastroenterol Clin North Am"},{"key":"2025090723021334000_49.3.354.20","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90011-X"},{"key":"2025090723021334000_49.3.354.21","first-page":"G4257","article-title":"Manometric evaluation of esophageal function utilizing a miniature Dent sleeve: within and between session reproducibility in healthy controls.","volume":"115","author":"Crowell","year":"1999","journal-title":"Gastroenterology"},{"key":"2025090723021334000_49.3.354.22","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0016-5085(81)90716-2","article-title":"Gastric emptying in patients with gastroesophageal reflux.","volume":"80","author":"McCallum","year":"1981","journal-title":"Gastroenterology"},{"key":"2025090723021334000_49.3.354.23","doi-asserted-by":"publisher","DOI":"10.1136\/gut.40.2.167"},{"key":"2025090723021334000_49.3.354.24","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v111.pm8898632"},{"key":"2025090723021334000_49.3.354.25","first-page":"54","article-title":"The effect of posture on gastroesophageal reflux event frequency and composition during fasting.","volume":"91","author":"Shay","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"2025090723021334000_49.3.354.26","doi-asserted-by":"publisher","DOI":"10.1136\/gut.42.2.251"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.49.3.354","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T06:02:19Z","timestamp":1757311339000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.49.3.354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,9,1]]},"references-count":26,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2001,9,1]]},"published-print":{"date-parts":[[2001,9,1]]}},"alternative-id":["10.1136\/gut.49.3.354"],"URL":"https:\/\/doi.org\/10.1136\/gut.49.3.354","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[2001,9,1]]}}}