{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T19:43:23Z","timestamp":1789242203643,"version":"build-2803163510"},"reference-count":21,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[2001,3,12]]},"published-print":{"date-parts":[[2001,11,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Malignancy, hypercoagulability, and conditions leading to decreased portal flow have been reported to contribute to the aetiology of extrahepatic portal vein thrombosis (EPVT). Mortality of patients with EPVT may be associated with these concurrent medical conditions or with manifestations of portal hypertension, such as variceal haemorrhage.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>PATIENTS AND METHODS<\/jats:title>\n                  <jats:p>To determine which variables have prognostic significance with respect to survival, we performed a retrospective study of 172 adult EPVT patients who were followed over the period 1984\u20131997 in eight university hospitals.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Mean follow up was 3.9 years (range 0.1\u201313.1). Overall survival was 70% (95% confidence interval (CI) 62\u201376%) at one year, 61% (95% CI, 52\u201367%) at five years, and 54% (95% CI, 45\u201362%) at 10 years. The one, five, and 10 year survival rates in the absence of cancer, cirrhosis, and mesenteric vein thrombosis were 95% (95% CI 87\u201398%), 89% (95% CI 78\u201394%), and 81% (95% CI 67\u201389%), respectively (n=83). Variables at diagnosis associated with reduced survival according to multivariate analysis were advanced age, malignancy, cirrhosis, mesenteric vein thrombosis, absence of abdominal inflammation, and serum levels of aminotransferase and albumin. The presence of variceal haemorrhage and myeloproliferative disorders did not influence survival. Only four patients died due to variceal haemorrhage and one due to complications of a portosystemic shunt procedure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSION<\/jats:title>\n                  <jats:p>We conclude that mortality among patients with EPVT is related primarily to concurrent disorders leading to EPVT and not to complications of portal hypertension.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/gut.49.5.720","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:31:46Z","timestamp":1027751506000},"page":"720-724","source":"Crossref","is-referenced-by-count":242,"title":["Extrahepatic portal vein thrombosis: aetiology and determinants of survival"],"prefix":"10.1136","volume":"49","author":[{"given":"H L A","family":"Janssen","sequence":"first","affiliation":[{"name":"aDepartment of Gastroenterology and Hepatology, University Hospital Rotterdam, the Netherlands, \n\nbDepartment of Gastroenterology and Hepatology, University Hospital Groningen, the Netherlands, \n\ncDepartment of Internal Medicine, University Hospital St Radboud, Nijmegen, the Netherlands, \n\ndDepartment of Gastroenterology, Free University Hospital, Amsterdam, the Netherlands, \n\neDepartment of Gastroenterology, University Hospital Maastricht, the Netherlands, \n\nfDepartment of Gastroenterology, Academic Medi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Wijnhoud","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology and Hepatology, University Hospital Rotterdam, the Netherlands, \n\nbDepartment of Gastroenterology and Hepatology, University Hospital Groningen, the Netherlands, \n\ncDepartment of Internal Medicine, University Hospital St Radboud, Nijmegen, the Netherlands, \n\ndDepartment of Gastroenterology, Free University Hospital, Amsterdam, the Netherlands, \n\neDepartment of Gastroenterology, University Hospital Maastricht, the Netherlands, \n\nfDepartment of Gastroenterology, Academic Medi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E B","family":"Haagsma","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology and Hepatology, University Hospital Rotterdam, the Netherlands, \n\nbDepartment of Gastroenterology and Hepatology, University Hospital Groningen, the Netherlands, \n\ncDepartment of Internal Medicine, University Hospital St Radboud, Nijmegen, the Netherlands, \n\ndDepartment of Gastroenterology, Free University Hospital, Amsterdam, the Netherlands, \n\neDepartment of Gastroenterology, University Hospital Maastricht, the Netherlands, \n\nfDepartment of Gastroenterology, Academic Medi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S H M","family":"van Uum","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology and Hepatology, University Hospital Rotterdam, the Netherlands, \n\nbDepartment of Gastroenterology and Hepatology, University Hospital Groningen, the Netherlands, \n\ncDepartment of Internal Medicine, University Hospital St Radboud, Nijmegen, the Netherlands, \n\ndDepartment of Gastroenterology, Free University Hospital, Amsterdam, the Netherlands, \n\neDepartment of Gastroenterology, University Hospital Maastricht, the Netherlands, \n\nfDepartment of Gastroenterology, Academic Medi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C M J","family":"van Nieuwkerk","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology and Hepatology, University Hospital Rotterdam, the Netherlands, \n\nbDepartment of Gastroenterology and Hepatology, University Hospital Groningen, the Netherlands, \n\ncDepartment of Internal Medicine, University Hospital St Radboud, Nijmegen, the Netherlands, \n\ndDepartment of Gastroenterology, Free University Hospital, Amsterdam, the Netherlands, \n\neDepartment of Gastroenterology, University Hospital Maastricht, the Netherlands, \n\nfDepartment of Gastroenterology, Academic Medi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R P","family":"Adang","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology and Hepatology, University Hospital Rotterdam, the Netherlands, \n\nbDepartment of Gastroenterology and Hepatology, University Hospital Groningen, the Netherlands, \n\ncDepartment of Internal Medicine, University Hospital St Radboud, Nijmegen, the Netherlands, \n\ndDepartment of Gastroenterology, Free University Hospital, Amsterdam, the Netherlands, \n\neDepartment of Gastroenterology, University Hospital Maastricht, the Netherlands, \n\nfDepartment of Gastroenterology, Academic Medi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R A F M","family":"Chamuleau","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology and Hepatology, University Hospital Rotterdam, the Netherlands, \n\nbDepartment of Gastroenterology and Hepatology, University Hospital Groningen, the Netherlands, \n\ncDepartment of Internal Medicine, University Hospital St Radboud, Nijmegen, the Netherlands, \n\ndDepartment of Gastroenterology, Free University Hospital, Amsterdam, the Netherlands, \n\neDepartment of Gastroenterology, University Hospital Maastricht, the Netherlands, \n\nfDepartment of Gastroenterology, Academic Medi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"van Hattum","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology and Hepatology, University Hospital Rotterdam, the Netherlands, \n\nbDepartment of Gastroenterology and Hepatology, University Hospital Groningen, the Netherlands, \n\ncDepartment of Internal Medicine, University Hospital St Radboud, Nijmegen, the Netherlands, \n\ndDepartment of Gastroenterology, Free University Hospital, Amsterdam, the Netherlands, \n\neDepartment of Gastroenterology, University Hospital Maastricht, the Netherlands, \n\nfDepartment of Gastroenterology, Academic Medi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F P","family":"Vleggaar","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology and Hepatology, University Hospital Rotterdam, the Netherlands, \n\nbDepartment of Gastroenterology and Hepatology, University Hospital Groningen, the Netherlands, \n\ncDepartment of Internal Medicine, University Hospital St Radboud, Nijmegen, the Netherlands, \n\ndDepartment of Gastroenterology, Free University Hospital, Amsterdam, the Netherlands, \n\neDepartment of Gastroenterology, University Hospital Maastricht, the Netherlands, \n\nfDepartment of Gastroenterology, Academic Medi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B E","family":"Hansen","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology and Hepatology, University Hospital Rotterdam, the Netherlands, \n\nbDepartment of Gastroenterology and Hepatology, University Hospital Groningen, the Netherlands, \n\ncDepartment of Internal Medicine, University Hospital St Radboud, Nijmegen, the Netherlands, \n\ndDepartment of Gastroenterology, Free University Hospital, Amsterdam, the Netherlands, \n\neDepartment of Gastroenterology, University Hospital Maastricht, the Netherlands, \n\nfDepartment of Gastroenterology, Academic Medi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F R","family":"Rosendaal","sequence":"additional","affiliation":[{"name":"aDepartment of Gastroenterology and Hepatology, University Hospital Rotterdam, the Netherlands, \n\nbDepartment of Gastroenterology and Hepatology, University Hospital Groningen, the Netherlands, \n\ncDepartment of Internal Medicine, University Hospital St Radboud, Nijmegen, the Netherlands, \n\ndDepartment of Gastroenterology, Free University Hospital, Amsterdam, the Netherlands, \n\neDepartment of Gastroenterology, University Hospital Maastricht, the Netherlands, 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