{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T18:35:05Z","timestamp":1773340505768,"version":"3.50.1"},"reference-count":15,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[2001,5,1]]},"published-print":{"date-parts":[[2001,11,1]]},"abstract":"<jats:p>Few patients with Beh\u00e7et's syndrome have gastrointestinal ulceration. Such patients are difficult to treat and have a higher mortality. Faced with refractory symptoms in two patients with intestinal Beh\u00e7et's, we used the tumour necrosis factor \u03b1 (TNF-\u03b1) monoclonal antibody infliximab to induce remission. Both women (one aged 27 years, the other 30 years) presented with orogenital ulceration, pustular rash, abdominal pain, bloody diarrhoea due to colonic ulceration, weight loss, and synovitis. One had thrombophlebitis, digital vasculitis, perianal fistula, and paracolic abscess; the other had conjunctivitis and an ulcer in the natal cleft. Treatment with prednisolone, methyl prednisolone, and thalidomide in one and prednisolone, colchicine, and cyclosporin in the other was ineffective. After full discussion, infliximab (3 mg\/kg, dose reduced because of recent sepsis in one, and 5 mg\/kg in the other) was administered. Within 10 days the ulcers healed, with resolution of bloody diarrhoea and all extraintestinal manifestations. A second infusion of infliximab was necessary eight weeks later in one case, followed by sustained (&gt;15 months) remission on low dose thalidomide. Remission was initially sustained for 12 months in the other but thalidomide had to be stopped due to intolerance, and a good response to retreatment lasted only 12 weeks without immunosuppression, before a third infusion. The cause of Beh\u00e7et's syndrome is unknown but peripheral blood CD45 \u03b3\u03b4 T cells in Beh\u00e7et's produce &gt;50-fold more TNF-\u03b1 than controls when stimulated with phorbol myristate acetate and anti-CD3. Infliximab could have a role for inducing remission in Beh\u00e7et's syndrome.<\/jats:p>","DOI":"10.1136\/gut.49.5.725","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:31:46Z","timestamp":1027751506000},"page":"725-728","source":"Crossref","is-referenced-by-count":115,"title":["Treatment of intestinal Beh\u00e7et's syndrome with chimeric tumour necrosis factor \u03b1 antibody"],"prefix":"10.1136","volume":"49","author":[{"given":"S P L","family":"Travis","sequence":"first","affiliation":[{"name":"aGastroenterology Unit, Derriford Hospital, Plymouth PL6 8DH, UK, \n\nbGastroenterology Unit, Royal Victoria Hospital and Queen's University Hospital, Belfast BT9 7JB, UK, \n\ncMusculoskeletal Education and Research Unit, Royal Victoria Hospital and Queen's University Hospital, Belfast BT9 7JB, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Czajkowski","sequence":"additional","affiliation":[{"name":"aGastroenterology Unit, Derriford Hospital, Plymouth PL6 8DH, UK, \n\nbGastroenterology Unit, Royal Victoria Hospital and Queen's University Hospital, Belfast BT9 7JB, UK, \n\ncMusculoskeletal Education and Research Unit, Royal Victoria Hospital and Queen's University Hospital, Belfast BT9 7JB, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D P B","family":"McGovern","sequence":"additional","affiliation":[{"name":"aGastroenterology Unit, Derriford Hospital, Plymouth PL6 8DH, UK, \n\nbGastroenterology Unit, Royal Victoria Hospital and Queen's University Hospital, Belfast BT9 7JB, UK, \n\ncMusculoskeletal Education and Research Unit, Royal Victoria Hospital and Queen's University Hospital, Belfast BT9 7JB, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R G P","family":"Watson","sequence":"additional","affiliation":[{"name":"aGastroenterology Unit, Derriford Hospital, Plymouth PL6 8DH, UK, \n\nbGastroenterology Unit, Royal Victoria Hospital and Queen's University Hospital, Belfast BT9 7JB, UK, \n\ncMusculoskeletal Education and Research Unit, Royal Victoria Hospital and Queen's University Hospital, Belfast BT9 7JB, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A L","family":"Bell","sequence":"additional","affiliation":[{"name":"aGastroenterology Unit, Derriford Hospital, Plymouth PL6 8DH, UK, \n\nbGastroenterology Unit, Royal Victoria Hospital and Queen's University Hospital, Belfast BT9 7JB, UK, \n\ncMusculoskeletal Education and Research Unit, Royal Victoria Hospital and Queen's University Hospital, Belfast BT9 7JB, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2001,11,1]]},"reference":[{"key":"2025121307192946000_49.5.725.1","first-page":"1078","article-title":"Criteria for diagnosis of Beh\u00e7et's disease.","volume":"335","year":"1990","journal-title":"Lancet"},{"key":"2025121307192946000_49.5.725.2","first-page":"169","article-title":"Beh\u00e7et's 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