{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:09:35Z","timestamp":1761764975644,"version":"3.44.0"},"reference-count":22,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1964,8]]},"abstract":"<jats:p>The toxic action of wheat gluten on two patients was eliminated after predigestion of gluten by crude papain. This change is thought to be due to an enzyme which liberates ammonia from gluten. It is not thought that this particular mechanism operates in the normal intestinal cell but it is envisaged that one of the peptide bonds of the coeliac active constituent (possibly a N-glutaminyl peptide) is normally split by a specific intestinal peptidase which is defective in coeliac patients.<\/jats:p>","DOI":"10.1136\/gut.5.4.295","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"295-303","source":"Crossref","is-referenced-by-count":42,"title":["Studies on the mechanism of destruction of the toxic action of wheat gluten in coeliac disease by crude papain"],"prefix":"10.1136","volume":"5","author":[{"given":"M.","family":"Messer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte M.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lois","family":"Hubbard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1964,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1042\/bj0670423","article-title":"Liver and brain mitochondria","volume":"67","author":"Aldridge, W.N.","year":"1957","unstructured":"Aldridge, W. N. (1957). Liver and brain mitochondria. Biochem. J., 67, 423-431.","journal-title":"Biochem. J"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1136\/adc.32.165.434","article-title":"Wheat gluten and coeliac disease","volume":"32","author":"Alvey, C.; Anderson, C.M.; Freeman, M.","year":"1957","unstructured":"Alvey, C., Anderson, C. M., and Freeman, M. (1957). Wheat gluten and coeliac disease. Arch. Dis. Childh., 32, 434-437.","journal-title":"Arch. Dis. Childh"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/S0021-9673(01)92900-0","article-title":"Improved separation of amino-acids with a new solvent system for two-dimensional paper chromatography","volume":"5","author":"Ambe, K.S.; Tappel, A.L.","year":"1961","unstructured":"Ambe, K. S., and Tappel, A. L. (1961). Improved separation of amino-acids with a new solvent system for two-dimensional paper chromatography. J. Chromatog., 5, 546-548.","journal-title":"J. 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