{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T03:25:41Z","timestamp":1772853941314,"version":"3.50.1"},"reference-count":21,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[2001,6,5]]},"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:p>Background: Six to 12 months of ingestion of moderate amounts of oats does not have a harmful effect in adult patients with coeliac disease. As the safety of long term intake of oats in coeliac patients is not known, we continued our previous 6\u201312 month study for five years.<\/jats:p>\n                  <jats:p>Aim: To assess the safety of long term ingestion of oats in the diet of coeliac patients.<\/jats:p>\n                  <jats:p>Patients: In our previous study, the effects of a gluten free diet and a gluten free diet including oats were compared in a randomised trial involving 92 adult patients with coeliac disease (45 in the oats group, 47 in the control group). After the initial phase of 6\u201312 months, patients in the oats group were allowed to eat oats freely in conjunction with an otherwise gluten free diet. After five years, 35 patients in the original oats group (23 still on an oats diet) and 28 in the control group on a conventional gluten free diet were examined.<\/jats:p>\n                  <jats:p>Methods: Clinical and nutritional assessment, duodenal biopsies for conventional histopathology and histomorphometry, and measurement of antiendomysial, antireticulin, and antigliadin antibodies.<\/jats:p>\n                  <jats:p>Results: There were no significant differences between controls and those patients consuming oats with respect to duodenal villous architecture, inflammatory cell infiltration of the duodenal mucosa, or antibody titres after five years of follow up. In both groups histological and histomorphometric indexes improved equally with time.<\/jats:p>\n                  <jats:p>Conclusions: This study provides the first evidence of the long term safety of oats as part of a coeliac diet in adult patients with coeliac disease. It also appears that the majority of coeliac patients prefer oats in their diet.<\/jats:p>","DOI":"10.1136\/gut.50.3.332","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:29:57Z","timestamp":1027751397000},"page":"332-335","source":"Crossref","is-referenced-by-count":206,"title":["No harm from five year ingestion of oats in coeliac disease"],"prefix":"10.1136","volume":"50","author":[{"given":"E K","family":"Janatuinen","sequence":"first","affiliation":[{"name":"Gastroenterological Unit, Department of Medicine, Kuopio University Hospital, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T A","family":"Kemppainen","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, University of Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R J K","family":"Julkunen","sequence":"additional","affiliation":[{"name":"Gastroenterological Unit, Department of Medicine, Kuopio University Hospital, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V-M","family":"Kosma","sequence":"additional","affiliation":[{"name":"Department of Pathology and Forensic Medicine, University of Kuopio and Kuopio University Hospital, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"M\u00e4ki","sequence":"additional","affiliation":[{"name":"Institute of Medical Technology, University of Tampere, Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Heikkinen","sequence":"additional","affiliation":[{"name":"Gastroenterological Unit, Department of Medicine, Kuopio University Hospital, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M I J","family":"Uusitupa","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, University of Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2002,3,1]]},"reference":[{"key":"2025121313322154000_50.3.332.1","unstructured":"Dicke WK. Coeliakie. Een onderzoek nar de nadelige invloed van sommige graansoorten op de lijder aan coeliakie. Thesis, Utrecht, Netherlands, 1950."},{"key":"2025121313322154000_50.3.332.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1953.tb05586.x"},{"key":"2025121313322154000_50.3.332.3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1953.tb05563.x"},{"key":"2025121313322154000_50.3.332.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199510193331602"},{"key":"2025121313322154000_50.3.332.5","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1136\/bmj.313.7068.1300","volume":"313","year":"1996","journal-title":"BMJ"},{"key":"2025121313322154000_50.3.332.6","first-page":"3339","volume":"96","year":"1999","journal-title":"L\u00e4kartidningen"},{"key":"2025121313322154000_50.3.332.7","first-page":"549","volume":"26","year":"1998","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"2025121313322154000_50.3.332.8","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2000.109003"},{"key":"2025121313322154000_50.3.332.9","doi-asserted-by":"publisher","DOI":"10.1136\/gut.46.3.327"},{"key":"2025121313322154000_50.3.332.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)91627-6"},{"key":"2025121313322154000_50.3.332.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(84)80074-8"},{"key":"2025121313322154000_50.3.332.12","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199808000-00015"},{"key":"2025121313322154000_50.3.332.13","unstructured":"Altman DG, Gardner MJ. Calculating confidence intervals for means and their differences. In: Gardner MJ, Altman DG, eds. Statistics with confidence\u2014confidence intervals and statistical guidelines. Belfast: The Universities Press Ltd, 1989:20\u20137."},{"key":"2025121313322154000_50.3.332.14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199712253372604"},{"key":"2025121313322154000_50.3.332.15","doi-asserted-by":"publisher","DOI":"10.1136\/gut.43.4.490"},{"key":"2025121313322154000_50.3.332.16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199510193331610"},{"key":"2025121313322154000_50.3.332.17","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.314.7075.159"},{"key":"2025121313322154000_50.3.332.18","first-page":"1065","volume":"II","year":"1972","journal-title":"Lancet"},{"key":"2025121313322154000_50.3.332.19","unstructured":"Kassandra D. Gluten and gliadin: Precipitating factors in coeliac disease. In: M\u00e4ki M, Collin P, Visakorpi JK, eds. Coeliac disease. Vammala: Vammalan Kirjapaino, 1997:195\u2013212."},{"key":"2025121313322154000_50.3.332.20","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901283400417"},{"key":"2025121313322154000_50.3.332.21","doi-asserted-by":"publisher","DOI":"10.1136\/adc.63.8.916"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.50.3.332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T21:32:31Z","timestamp":1765661551000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.50.3.332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3]]},"references-count":21,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2002,3,1]]},"published-print":{"date-parts":[[2002,3]]}},"alternative-id":["10.1136\/gut.50.3.332"],"URL":"https:\/\/doi.org\/10.1136\/gut.50.3.332","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,3]]}}}