{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T21:46:14Z","timestamp":1782251174241,"version":"3.54.5"},"reference-count":31,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[2001,4,12]]},"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:p>Background and aims: It has been suggested that gastric cardia adenocarcinoma (GCA) is a distinct entity from oesophageal adenocarcinoma (OA). We examined several epidemiological features of GCA and OA in the USA to elucidate differences\/similarities between these malignancies.<\/jats:p>\n                  <jats:p>Methods: Using the database of Surveillance, Epidemiology, and End Results (SEER) program, we examined incidence rates for temporal changes, and ethnic and age distributions, and performed birth cohort analyses for cases with morphologically and histologically confirmed OA or GCA.<\/jats:p>\n                  <jats:p>Results: The age adjusted incidence rates of OA rose progressively, reaching 1.8 per 100 000 (95% confidence interval 1.7\u20131.9) during 1987\u20131991 and 2.5 per 100 000 (2.3\u20132.6) during 1992\u20131996. In 1992\u20131996, Whites were affected five times more than Blacks, and men eight times more than women. A significant increase in incidence occurred among younger persons aged 45\u201365 years. Irrespective of age, OA was characterised by higher incidence rates among more recent birth cohorts: a 40% increase in incidence for each five year increase in the date of birth\u2014a \u201cbirth cohort effect\u201d. On the other hand, the incidence rates of GCA reached their highest level of 3.3 per 100 000 (3.2\u20133.4) in 1987\u20131991 and subsequently declined during 1992\u20131996 to 3.1 per 100 000 (3.0\u20133.3). Whites were affected twice more than blacks and men five times more than women. Most patients with GCA were older than 60 years with no increase among younger persons and no birth cohort effect (p=0.99).<\/jats:p>\n                  <jats:p>Conclusion: Several significant epidemiological differences exist between OA and GCA. These differences suggest that these two malignancies are separate entities with different risk factors.<\/jats:p>","DOI":"10.1136\/gut.50.3.368","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T06:29:57Z","timestamp":1027751397000},"page":"368-372","source":"Crossref","is-referenced-by-count":203,"title":["Epidemiological differences between adenocarcinoma of the oesophagus and adenocarcinoma of the gastric cardia in the USA"],"prefix":"10.1136","volume":"50","author":[{"given":"H B","family":"El-Serag","sequence":"first","affiliation":[{"name":"Sections of Gastroenterology and Health Services Research, Houston Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A C","family":"Mason","sequence":"additional","affiliation":[{"name":"University of New Mexico, Albuquerque, New Mexico, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Petersen","sequence":"additional","affiliation":[{"name":"Health Services Research Section, Houston Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C R","family":"Key","sequence":"additional","affiliation":[{"name":"University of New Mexico, Albuquerque, New Mexico, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2002,3,1]]},"reference":[{"key":"2025121220244193000_50.3.368.1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03460100089030"},{"key":"2025121220244193000_50.3.368.2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19981115)83:10<2049::AID-CNCR1>3.0.CO;2-2"},{"key":"2025121220244193000_50.3.368.3","doi-asserted-by":"publisher","DOI":"10.1136\/gut.43.3.327"},{"key":"2025121220244193000_50.3.368.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198608073150605"},{"key":"2025121220244193000_50.3.368.5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.1998.08031.x"},{"key":"2025121220244193000_50.3.368.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.00924.x"},{"key":"2025121220244193000_50.3.368.7","first-page":"1818","volume":"92","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"2025121220244193000_50.3.368.8","first-page":"414","volume":"92","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"2025121220244193000_50.3.368.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70571-8"},{"key":"2025121220244193000_50.3.368.10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199903183401101"},{"key":"2025121220244193000_50.3.368.11","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-11-199906010-00003"},{"key":"2025121220244193000_50.3.368.12","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03530060048032"},{"key":"2025121220244193000_50.3.368.13","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.2.150"},{"key":"2025121220244193000_50.3.368.14","unstructured":"Surveillance, Epidemiology, and End Results (SEER) Program. 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