{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:47:52Z","timestamp":1789429672100,"version":"build-2803163510"},"reference-count":43,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Although familial clusters of Barrett\u2019s oesophagus and oesophageal adenocarcinoma have been reported, a familial predisposition to these diseases has not been systematically investigated.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Aims:<\/jats:bold>\n                    To determine whether Barrett\u2019s oesophagus and oesophageal (or oesophagogastric junctional) adenocarcinoma aggregate in families.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Patients and methods:<\/jats:bold>\n                    A structured questionnaire eliciting details on reflux symptoms, exposure history, and family history was given to Caucasian case (n=58) subjects with Barrett\u2019s oesophagus, oesophageal adenocarcinoma, or oesophagogastric junctional adenocarcinoma, and to Caucasian control (n=106) subjects with symptomatic gastro-oesophageal reflux disease without Barrett\u2019s oesophagus. Reported diagnoses of family members were confirmed by review of medical records.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    The presence of a positive family history (that is, first or second degree relative with Barrett\u2019s oesophagus, oesophageal adenocarcinoma, or oesophagogastric junctional adenocarcinoma) was significantly higher among case subjects compared with controls (24%\n                    <jats:italic>v<\/jats:italic>\n                    5%; p&lt;0.005). Case subjects were more likely to be older (p&lt;0.001) and male (74%\n                    <jats:italic>v<\/jats:italic>\n                    43% male; p&lt;0.0005) compared with control subjects. In a multivariate logistic regression analysis, family history was independently associated with the presence of Barrett\u2019s oesophagus, oesophageal adenocarcinoma, or oesophagogastric junctional adenocarcinoma (odds ratio 12.23, 95% confidence interval 3.34\u201344.76) after adjusting for age, sex, and the presence of obesity 10 or more years prior to study enrolment.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Individuals with Barrett\u2019s oesophagus, oesophageal adenocarcinoma, or oesophagogastric junctional adenocarcinoma are more likely to have a positive family history of Barrett\u2019s oesophagus, oesophageal adenocarcinoma, or oesophagogastric junctional adenocarcinoma than individuals without Barrett\u2019s oesophagus, oesophageal adenocarcinoma, or oesophagogastric junctional adenocarcinoma. A positive family history should be considered when making decisions about screening endoscopy in patients with symptoms of gastro-oesophageal reflux.\n                  <\/jats:p>","DOI":"10.1136\/gut.51.3.323","type":"journal-article","created":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T15:54:10Z","timestamp":1033487650000},"page":"323-328","source":"Crossref","is-referenced-by-count":174,"title":["Familial aggregation of Barrett\u2019s oesophagus, oesophageal adenocarcinoma, and oesophagogastric junctional adenocarcinoma in Caucasian adults"],"prefix":"10.1136","volume":"51","author":[{"given":"A","family":"Chak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M F","family":"Kinnard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Brock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Faulx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Willis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G S","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"M V","family":"Sivak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K A B","family":"Goddard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2002,9,1]]},"reference":[{"key":"2025121222135136000_51.3.323.1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03460100089030"},{"key":"2025121222135136000_51.3.323.2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19981115)83:10<2049::AID-CNCR1>3.0.CO;2-2"},{"key":"2025121222135136000_51.3.323.3","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.51.1.15"},{"key":"2025121222135136000_51.3.323.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198608073150605"},{"key":"2025121222135136000_51.3.323.5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ajcp\/70.1.1","volume":"70","year":"1978","journal-title":"Am J Clin Pathol"},{"key":"2025121222135136000_51.3.323.6","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870901)60:5<1094::AID-CNCR2820600529>3.0.CO;2-4"},{"key":"2025121222135136000_51.3.323.7","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90642-8"},{"key":"2025121222135136000_51.3.323.8","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1994.01420300051007"},{"key":"2025121222135136000_51.3.323.9","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/S0016-5085(89)80011-3","volume":"96","year":"1989","journal-title":"Gastroenterology"},{"key":"2025121222135136000_51.3.323.10","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/0016-5085(84)90090-8","volume":"87","year":"1984","journal-title":"Gastroenterology"},{"key":"2025121222135136000_51.3.323.11","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1056\/NEJM198510033131404","volume":"313","year":"1985","journal-title":"N Engl J Med"},{"key":"2025121222135136000_51.3.323.12","doi-asserted-by":"publisher","DOI":"10.1136\/gut.30.1.14"},{"key":"2025121222135136000_51.3.323.13","first-page":"212","volume":"92","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"2025121222135136000_51.3.323.14","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(85)80031-3"},{"key":"2025121222135136000_51.3.323.15","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/0016-5085(87)90847-X","volume":"92","year":"1987","journal-title":"Gastroenterology"},{"key":"2025121222135136000_51.3.323.16","first-page":"1494","volume":"84","year":"1989","journal-title":"Am J Gastroenterol"},{"key":"2025121222135136000_51.3.323.17","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/0016-5085(90)90607-3","volume":"99","year":"1990","journal-title":"Gastroenterology"},{"key":"2025121222135136000_51.3.323.18","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/0016-5085(92)91510-B","volume":"103","year":"1992","journal-title":"Gastroenterology"},{"key":"2025121222135136000_51.3.323.19","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-11-199906010-00003"},{"key":"2025121222135136000_51.3.323.20","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.2.150"},{"key":"2025121222135136000_51.3.323.21","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/87.11.847"},{"key":"2025121222135136000_51.3.323.22","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.17.1277"},{"key":"2025121222135136000_51.3.323.23","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(20000201)85:3<340::AID-IJC8>3.0.CO;2-N"},{"key":"2025121222135136000_51.3.323.24","first-page":"85","volume":"4","year":"1995","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2025121222135136000_51.3.323.25","doi-asserted-by":"publisher","DOI":"10.1007\/BF00053153"},{"key":"2025121222135136000_51.3.323.26","first-page":"165","volume":"133","year":"2000","journal-title":"Ann Intern Med"},{"key":"2025121222135136000_51.3.323.27","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/00004836-198306000-00011","volume":"5","year":"1983","journal-title":"J Clin Gastroenterol"},{"key":"2025121222135136000_51.3.323.28","first-page":"86","volume":"33","year":"1986","journal-title":"Hepatogastroenterology"},{"key":"2025121222135136000_51.3.323.29","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/0016-5085(92)90784-V","volume":"102","year":"1992","journal-title":"Gastroenterology"},{"key":"2025121222135136000_51.3.323.30","first-page":"397","volume":"2","year":"1993","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2025121222135136000_51.3.323.31","doi-asserted-by":"crossref","first-page":"52","DOI":"10.7326\/0003-4819-103-1-52","volume":"103","year":"1985","journal-title":"Ann Intern Med"},{"key":"2025121222135136000_51.3.323.32","first-page":"1262","volume":"88","year":"1993","journal-title":"Am J Gastroenterol"},{"key":"2025121222135136000_51.3.323.33","first-page":"1855","volume":"91","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"2025121222135136000_51.3.323.34","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v113.pm9352846"},{"key":"2025121222135136000_51.3.323.35","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1111\/j.1572-0241.1999.01060.x","volume":"94","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"2025121222135136000_51.3.323.36","doi-asserted-by":"crossref","first-page":"983","DOI":"10.7326\/0003-4819-103-6-983","volume":"103","year":"1985","journal-title":"Ann Intern Med"},{"key":"2025121222135136000_51.3.323.37","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0025-6196(12)62245-9","volume":"69","year":"1994","journal-title":"Mayo Clin Proc"},{"key":"2025121222135136000_51.3.323.38","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8553(05)70315-0"},{"key":"2025121222135136000_51.3.323.39","first-page":"757","volume":"9","year":"2000","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2025121222135136000_51.3.323.40","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1294"},{"key":"2025121222135136000_51.3.323.41","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.3.325"},{"key":"2025121222135136000_51.3.323.42","first-page":"23","volume":"91","year":"1987","journal-title":"J Clin Gastroenterol"},{"key":"2025121222135136000_51.3.323.43","first-page":"2040","volume":"92","year":"1997","journal-title":"Am J Gastroenterol"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.51.3.323","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T06:14:03Z","timestamp":1765606443000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.51.3.323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9]]},"references-count":43,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2002,9,1]]},"published-print":{"date-parts":[[2002,9]]}},"alternative-id":["10.1136\/gut.51.3.323"],"URL":"https:\/\/doi.org\/10.1136\/gut.51.3.323","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,9]]}}}