{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T18:10:51Z","timestamp":1765649451177,"version":"3.48.0"},"reference-count":27,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[2003,1]]},"abstract":"\n Background:<\/jats:bold>\n Previous studies on the treatment of\n Helicobacter pylori<\/jats:italic>\n infection in functional dyspepsia have shown little, if any, effect on dyspeptic symptoms. However, whether such treatment might be of benefit in patients resistant to acid inhibitors has not been formally tested.\n <\/jats:p>\n \n Aim:<\/jats:bold>\n The present study investigated the effect of\n H pylori<\/jats:italic>\n treatment in patients with functional dyspepsia resistant to conventional treatment.\n <\/jats:p>\n \n Patients:<\/jats:bold>\n A total of 181\n H pylori<\/jats:italic>\n positive patients with chronic functional dyspepsia who had not responded to a one week antacid run-in and two week double blind antisecretory or placebo treatment were included.\n <\/jats:p>\n \n Methods:<\/jats:bold>\n Patients were randomised to two weeks of treatment with omeprazole 40 mg twice daily combined with amoxicillin 1 g twice daily or omeprazole 20 mg once daily alone. The primary outcome variable (\u201cresponse\u201d) was defined as no need for further therapy or investigations for dyspeptic symptoms 4\u20136 months after treatment.\n <\/jats:p>\n \n Results:<\/jats:bold>\n H pylori<\/jats:italic>\n infection was healed in 10% of patients after omeprazole and in 52% after omeprazole plus amoxicillin. The respective \u201cresponse\u201d rates were 66% and 62% (NS).\n H pylori<\/jats:italic>\n treatment and cure of\n H pylori<\/jats:italic>\n infection had no effect on complete resolution of all dyspeptic symptoms, individual symptoms, or various aspects of quality of life.\n <\/jats:p>\n \n Conclusion:<\/jats:bold>\n In functional dyspepsia,\n H pylori<\/jats:italic>\n treatment and cure of\n H pylori<\/jats:italic>\n are no more effective for symptoms over six months than short term acid inhibition. These results do not support treatment of\n H pylori<\/jats:italic>\n in functional dyspepsia.\n <\/jats:p>","DOI":"10.1136\/gut.52.1.40","type":"journal-article","created":{"date-parts":[[2002,12,11]],"date-time":"2002-12-11T17:02:39Z","timestamp":1039626159000},"page":"40-46","source":"Crossref","is-referenced-by-count":24,"title":["Treatment of\n Helicobacter pylori<\/i>\n in functional dyspepsia resistant to conventional management: a double blind randomised trial with a six month follow up"],"prefix":"10.1136","volume":"52","author":[{"given":"H 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