{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:33:39Z","timestamp":1790670819139,"version":"4.1.0"},"reference-count":25,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:p>\n                    We report a case of fulminant Crohn\u2019s colitis that occurred following non-myeloablative allogeneic stem cell transplantation for Hodgkin\u2019s lymphoma. Adoptive transfer of inflammatory bowel disease by haematopoietic cells is recognised in several animal models of inflammatory bowel disease and remission of Crohn\u2019s disease has been reported in patients who have received a bone marrow transplant. However, adoptive transfer of Crohn\u2019s disease susceptibility leading to phenotypic manifestation of the disease after transplantation has not been previously reported. Having ruled out an infective cause of a colitis in this case, we speculated that adoptive transfer of Crohn\u2019s disease may have occurred and performed a genetic analysis of known susceptibility loci for significant donor-recipient mismatches. The donor and recipient had several haplotype mismatches in HLA class III genes at the IBD3 locus. In addition, the donor (but not the recipient) had a polymorphism of the 5\u2032 UTR of\n                    <jats:italic>NOD2\/CARD15<\/jats:italic>\n                    that may be associated with Crohn\u2019s disease. This case highlights the question of whether adoptive transfer of Crohn\u2019s disease can occur between allogeneic stem cell transplant donor and recipient, in a similar fashion to that reported for other autoimmune diseases. This report should also stimulate debate regarding the need for stem cell transplant donor screening for inflammatory bowel disease.\n                  <\/jats:p>","DOI":"10.1136\/gut.52.10.1518","type":"journal-article","created":{"date-parts":[[2003,9,11]],"date-time":"2003-09-11T13:56:15Z","timestamp":1063288575000},"page":"1518-1521","source":"Crossref","is-referenced-by-count":58,"title":["Fulminant Crohn\u2019s colitis after allogeneic stem cell transplantation: \n            Figure 1"],"prefix":"10.1136","volume":"52","author":[{"given":"S A","family":"Sonwalkar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R M","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C S","family":"Verbeke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D L","family":"Barnard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D P","family":"Jewell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M A","family":"Hull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2003,9,11]]},"reference":[{"key":"2025121321471068000_52.10.1518.1","unstructured":"Katz JA, Fiocchi C. 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