{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T21:25:25Z","timestamp":1766697925032,"version":"3.48.0"},"reference-count":29,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:p>\n                    <jats:bold>Background and aim:<\/jats:bold>\n                    There are few data on the course of\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    infection in asymptomatic subjects. The aim of this study was to assess the effect of eradication therapy on the development of dyspeptic and gastro-oesophageal reflux disease in a cohort of asymptomatic individuals observed over a prolonged period.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    A total of 169 blood donors infected with\n                    <jats:italic>H pylori<\/jats:italic>\n                    who had volunteered for studies on eradication in 1990 formed the cohort. To be included in this cohort subjects had to have no symptoms, as determined by a validated symptom questionnaire at the baseline visit. Eighty eight subjects were infected with\n                    <jats:italic>H pylori<\/jats:italic>\n                    while 81 had successfully undergone eradication therapy. Subjects were followed up (annually) using the same symptom questionnaire and in 2000 they underwent repeat endoscopy.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Thirteen subjects developed symptoms during follow up. The incidence of symptoms in\n                    <jats:italic>H pylori<\/jats:italic>\n                    positive subjects was 1.893\/100 person-years of follow up and in\n                    <jats:italic>H pylori<\/jats:italic>\n                    negative individuals 0.163\/100 person-years of follow up.\n                    <jats:italic>H pylori<\/jats:italic>\n                    infected subjects were significantly more likely to develop symptoms (log rank test, p=0.003) as well as those infected with CagA positive strains (log rank test, p=0.017). The development of symptomatic gastro-oesophageal reflux disease was no different in individuals with and without eradication (odds ratio 0.57 (95% confidence interval 0.26\u20131.24); p=0.163).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    <jats:italic>H pylori<\/jats:italic>\n                    eradication prevents the development of dyspeptic symptoms and peptic ulcer disease in healthy asymptomatic blood donors and is not associated with an increase in the incidence of symptomatic gastro-oesophageal reflux disease.\n                  <\/jats:p>","DOI":"10.1136\/gut.52.11.1543","type":"journal-article","created":{"date-parts":[[2003,10,21]],"date-time":"2003-10-21T21:43:34Z","timestamp":1066772614000},"page":"1543-1547","source":"Crossref","is-referenced-by-count":25,"title":["Effect of\n                    <i>Helicobacter pylori<\/i>\n                    eradication on development of dyspeptic and reflux disease in healthy asymptomatic subjects"],"prefix":"10.1136","volume":"52","author":[{"given":"D","family":"Vaira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Vakil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Rugge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Gatta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Menegatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Leandro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Holton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V M","family":"Russo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Miglioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2003,10,21]]},"reference":[{"key":"2025121309332158000_52.11.1543.1","unstructured":"lnternational Agency for Research on Cancer, World Health Organization. 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