{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T10:27:50Z","timestamp":1765621670834,"version":"3.48.0"},"reference-count":31,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[2003,2]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Intestinal metaplasia (IM) in the oesophagus is a known risk factor for adenocarcinoma of the oesophagus. The incidence of adenocarcinoma of the cardia and oesophagus has increased in Western countries simultaneously with a decrease in\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    prevalence.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Aims:<\/jats:bold>\n                    To determine the association of\n                    <jats:italic>H pylori<\/jats:italic>\n                    infection with inflammation and IM at the squamocolumnar junction (SCJ) in young individuals.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Patients:<\/jats:bold>\n                    A total of 168 (121 women; 72%) consecutive outpatients, \u226445 years, undergoing gastroscopy, and with no prior\n                    <jats:italic>H pylori<\/jats:italic>\n                    eradication treatment.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Biopsy specimens taken from the antrum, corpus, SCJ, and oesophagus were assessed according to the updated Sydney system, and type of IM (complete or incomplete) was determined. Serum samples from\n                    <jats:italic>H pylori<\/jats:italic>\n                    positive patients were studied for CagA antibodies.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    In 86% of 37 patients with gastritis in the antrum and\/or corpus (24 histologically\n                    <jats:italic>H pylori<\/jats:italic>\n                    positive) and in 23% of 125 patients with a healthy stomach, inflammation was present in the glandular mucosa at the SCJ. In the latter, cardiac mucosa more often than fundic mucosa at the SCJ was inflamed (p&lt;0.001), the inflammation was usually milder in nature, and was associated with signs of reflux disease. IM (incomplete or complete) at the SCJ was evident in nine of those 24 with a healthy stomach and inflamed cardiac mucosa at the SCJ but in none of those with\n                    <jats:italic>H pylori<\/jats:italic>\n                    gastritis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    IM at the SCJ can also appear in young individuals in whom it seems to be associated with reflux related isolated inflammation in cardiac mucosa at the SCJ but not with\n                    <jats:italic>H pylori<\/jats:italic>\n                    gastritis.\n                  <\/jats:p>","DOI":"10.1136\/gut.52.2.194","type":"journal-article","created":{"date-parts":[[2003,1,10]],"date-time":"2003-01-10T14:05:40Z","timestamp":1042207540000},"page":"194-198","source":"Crossref","is-referenced-by-count":19,"title":["Inflammation and intestinal metaplasia at the squamocolumnar junction in young patients with 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