{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T21:04:41Z","timestamp":1780088681367,"version":"3.54.0"},"reference-count":21,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Coeliac disease patients show a number of gastrointestinal motor abnormalities, including a decrease in lower oesophageal sphincter pressure. The prevalence of endoscopic oesophagitis in these subjects however is unknown.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Aim:<\/jats:bold>\n                    To evaluate whether untreated adult coeliac patients had an increased prevalence of reflux oesophagitis and, if so, to assess whether a gluten free diet exerted any beneficial effect on gastro-oesophageal reflux disease (GORD) symptoms.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Patients and methods:<\/jats:bold>\n                    We retrospectively studied 205 coeliac patients (females\/males 153\/52, median age 32 years) who underwent endoscopy for duodenal biopsy and 400 non-coeliac subjects (females\/males 244\/156, median age 37 years) referred for endoscopy for upper gastrointestinal symptoms. Each patient was given a questionnaire for evaluation of GORD symptoms prior to and 4\u201312 months after endoscopy. Coeliac patients were given a gluten free diet. Oesophagitis patients of both groups, following an eight week course of omeprazole, were re-evaluated for GORD symptoms at four month intervals up to one year. Significance of differences was assessed by Fisher\u2019s exact test.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Oesophagitis was present in 39\/205 (19%, 95% confidence interval (CI) 13.8\u201325.0%) coeliac patients and in 32\/400 (8%, 95% CI 5.5\u201311.1%) dyspeptic subjects. At the one year follow up, GORD symptoms relapsed in 10\/39 (25.6%, 95% CI 13\u201342.1%) coeliacs with oesophagitis and in 23\/32 (71.8%, 95% CI 53.2\u201386.2%) non-coeliac subjects with oesophagitis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Coeliac patients have a high prevalence of reflux oesophagitis. That a gluten free diet significantly decreased the relapse rate of GORD symptoms suggests that coeliac disease may represent a risk factor for development of reflux oesophagitis.\n                  <\/jats:p>","DOI":"10.1136\/gut.52.4.514","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T17:42:13Z","timestamp":1047404533000},"page":"514-517","source":"Crossref","is-referenced-by-count":42,"title":["Reflux oesophagitis in adult coeliac disease: beneficial effect of a gluten free 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