{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:29:28Z","timestamp":1789054168751,"version":"build-2803163510"},"reference-count":30,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:p>\n                    <jats:bold>Background and aims:<\/jats:bold>\n                    Genetic variation in the chromosome 5q31 cytokine cluster (\n                    <jats:italic>IBD5<\/jats:italic>\n                    risk haplotype) has been associated with Crohn\u2019s disease (CD) in a Canadian population. We studied the\n                    <jats:italic>IBD5<\/jats:italic>\n                    risk haplotype in both British and Japanese cohorts. Disease associations have also been reported for\n                    <jats:italic>CARD15\/NOD2<\/jats:italic>\n                    and\n                    <jats:italic>TNF<\/jats:italic>\n                    variants. Complex interactions between susceptibility loci have been shown in animal models, and we tested for potential gene-gene interactions between the three CD associated loci.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Family based association analyses were performed in 457 British families (252 ulcerative colitis, 282 CD trios) genotyped for the\n                    <jats:italic>IBD5<\/jats:italic>\n                    haplotype, common\n                    <jats:italic>CARD15<\/jats:italic>\n                    , and\n                    <jats:italic>TNF<\/jats:italic>\n                    \u2212857 variants. To test for possible epistatic interactions between variants, transmission disequilibrium test analyses were further stratified by genotype at other loci, and novel log linear analyses were performed using the haplotype relative risk model. Case control association analyses were performed in 178 Japanese CD patients and 156 healthy controls genotyped for the\n                    <jats:italic>IBD5<\/jats:italic>\n                    haplotype.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    The\n                    <jats:italic>IBD5<\/jats:italic>\n                    haplotype was associated with CD (p=0.007), but not with UC, in the British Caucasian population. The\n                    <jats:italic>CARD15<\/jats:italic>\n                    variants and\n                    <jats:italic>IBD5<\/jats:italic>\n                    haplotype showed additive main effects, and in particular no evidence for epistatic interactions was found. Variants from the\n                    <jats:italic>IBD5<\/jats:italic>\n                    haplotype were extremely rare in the Japanese.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    The\n                    <jats:italic>IBD5<\/jats:italic>\n                    risk haplotype is associated with British CD. Genetic variants predisposing to CD show heterogeneity and population specific differences.\n                  <\/jats:p>","DOI":"10.1136\/gut.52.4.541","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T17:42:13Z","timestamp":1047404533000},"page":"541-546","source":"Crossref","is-referenced-by-count":87,"title":["Analysis of the\n                    <i>IBD5<\/i>\n                    locus and potential gene-gene interactions in Crohn\u2019s disease"],"prefix":"10.1136","volume":"52","author":[{"given":"K","family":"Negoro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D P 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