{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T22:56:48Z","timestamp":1765666608771,"version":"3.48.0"},"reference-count":41,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Mucosal biotransformation enzymes can modify toxic compounds in the gut. As chemical or oxidative stress may be involved in the aetiology of Crohn\u2019s disease, genes encoding for enzymes involved in the prevention of such stress may be candidates for genetic susceptibility to Crohn\u2019s disease.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Aim:<\/jats:bold>\n                    To assess the association of Crohn\u2019s disease with genetic polymorphisms in cytochrome P450 1A1, glutathione S-transferases mu-1, pi-1, and theta-1, and epoxide hydrolase.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    \u03c7\n                    <jats:sup>2<\/jats:sup>\n                    square analysis was used to compare frequencies of polymorphisms between 151 patients with Crohn\u2019s disease and 149 healthy controls.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    In patients, a genetic polymorphism in exon 3 of the microsomal epoxide hydrolase gene was distributed significantly different compared with controls (\u03c7\n                    <jats:sup>2<\/jats:sup>\n                    =23.7; p&lt;0.0001). All other polymorphisms tested were equally distributed between patients and controls.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Microsomal epoxide hydrolase may play a role in the pathophysiology of Crohn\u2019s disease. Furthermore, the epoxide hydrolase gene is located on chromosome 1q, close to a region previously linked to Crohn\u2019s disease.\n                  <\/jats:p>","DOI":"10.1136\/gut.52.4.547","type":"journal-article","created":{"date-parts":[[2003,3,11]],"date-time":"2003-03-11T17:42:13Z","timestamp":1047404533000},"page":"547-551","source":"Crossref","is-referenced-by-count":28,"title":["Genetic polymorphisms in biotransformation enzymes in Crohn\u2019s disease: association with microsomal epoxide hydrolase"],"prefix":"10.1136","volume":"52","author":[{"given":"D J","family":"de Jong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E M J","family":"van der Logt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"van Schaik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H M 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