{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T08:13:17Z","timestamp":1781597597297,"version":"3.54.5"},"reference-count":26,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[2002,12,17]]},"published-print":{"date-parts":[[2003,6]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Some forms of gastric intestinal metaplasia (GIM) may be precancerous but the cellular phenotype that predisposes to gastric carcinogenesis is not well characterised. Mucin staining, as a means of differentiating GIM, is difficult. A monoclonal antibody, mAb Das-1 (initially called 7E\n                    <jats:sub>12<\/jats:sub>\n                    H\n                    <jats:sub>12<\/jats:sub>\n                    ), whose staining is phenotypically specific to colon epithelium, was used to investigate this issue.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Using mAb Das-1, by a sensitive immunoperoxidase assay, we examined histologically confirmed GIM specimens from two countries, the USA and Japan. A total of 150 patients comprised three groups: group A, GIM (fields away from the cancer area) from patients with gastric carcinoma (n=60); group B, GIM with chronic gastritis (without gastric carcinoma) (n=72); and group C, chronic gastritis without GIM (n=18).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Fifty six of 60 (93%) patients with GIM (both goblet and non-goblet metaplastic cells) from group A reacted intensely with mAb Das-1. Cancer areas from the same 56 patients also reacted. In contrast, 25\/72 (35%) samples of GIM from patients in group B reacted with mAb Das-1 (group A\n                    <jats:italic>v<\/jats:italic>\n                    B, p&lt;0.0001). None of the samples from group C reacted with the mAb.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Reactivity of mAb Das-1 is clinically useful to simplify and differentiate the phenotypes of GIM. The colonic phenotype of GIM, as identified by mAb Das-1, is strongly associated with gastric carcinoma.\n                  <\/jats:p>","DOI":"10.1136\/gut.52.6.807","type":"journal-article","created":{"date-parts":[[2003,5,9]],"date-time":"2003-05-09T16:21:23Z","timestamp":1052497283000},"page":"807-812","source":"Crossref","is-referenced-by-count":36,"title":["Gastric intestinal metaplasia as detected by a monoclonal antibody is highly associated with gastric adenocarcinoma"],"prefix":"10.1136","volume":"52","author":[{"given":"Z K","family":"Mirza","sequence":"first","affiliation":[{"name":"Departments of Medicine and Pathology, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K K","family":"Das","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Pathology, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Slate","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Pathology, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R N","family":"Mapitigama","sequence":"additional","affiliation":[{"name":"Muhlenberg Regional Medical Center, Plainfield, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P S","family":"Amenta","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Pathology, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L H","family":"Griffel","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Pathology, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Ramsundar","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Pathology, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Watari","sequence":"additional","affiliation":[{"name":"Asahikawa Medical College, Asahikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Yokota","sequence":"additional","affiliation":[{"name":"Asahikawa Medical College, Asahikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Asahikawa Medical College, Asahikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Sato","sequence":"additional","affiliation":[{"name":"Asahikawa Medical College, Asahikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Kohgo","sequence":"additional","affiliation":[{"name":"Asahikawa Medical College, Asahikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K M","family":"Das","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Pathology, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2003,6,1]]},"reference":[{"key":"2025112111032574000_52.6.807.1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01886501"},{"key":"2025112111032574000_52.6.807.2","first-page":"231","volume":"65","year":"1980","journal-title":"Natl Cancer Inst"},{"key":"2025112111032574000_52.6.807.3","unstructured":"Filipe MI, Ramachandra S. The histochemistry of intestinal mucin; changes in disease. In: Whitehead R, ed. Gastrointestinal and Esophageal Pathology, 2nd edn. New York: Churchill Livingstone, 1995:73\u201395."},{"key":"2025112111032574000_52.6.807.4","doi-asserted-by":"publisher","DOI":"10.1007\/BF01002633"},{"key":"2025112111032574000_52.6.807.5","first-page":"56","volume":"74","year":"1994","journal-title":"Cancer"},{"key":"2025112111032574000_52.6.807.6","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/90.12.735"},{"key":"2025112111032574000_52.6.807.7","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/26.4.716"},{"key":"2025112111032574000_52.6.807.8","doi-asserted-by":"crossref","first-page":"77","DOI":"10.4049\/jimmunol.139.1.77","volume":"139","year":"1987","journal-title":"J Immunol"},{"key":"2025112111032574000_52.6.807.9","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.5.650"},{"key":"2025112111032574000_52.6.807.10","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-120-9-199405010-00006"},{"key":"2025112111032574000_52.6.807.11","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005449024524"},{"key":"2025112111032574000_52.6.807.12","unstructured":"Beckstead JH. 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