{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:54:21Z","timestamp":1772967261375,"version":"3.50.1"},"reference-count":5,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[2002,10,22]]},"published-print":{"date-parts":[[2003,6]]},"abstract":"<jats:p>The risk of periampullary cancer in patients with classic familial adenomatous polyposis (FAP) is significantly increased compared with the general population. However, the incidence of this extracolonic manifestation in attenuated FAP (AFAP) is unknown. We report the case of a 38 year old woman with no known family history of polyposis or colorectal cancer, who presented with ampullary adenocarcinoma. Diagnosis of AFAP was made only after evaluation of the patient\u2019s extended family history and genetic testing. This case report suggests that AFAP should be included in the differential diagnosis of patients with ampullary\/duodenal tumours.<\/jats:p>","DOI":"10.1136\/gut.52.6.903","type":"journal-article","created":{"date-parts":[[2003,5,9]],"date-time":"2003-05-09T16:21:23Z","timestamp":1052497283000},"page":"903-904","source":"Crossref","is-referenced-by-count":13,"title":["Attenuated familial adenomatous polyposis presenting as ampullary adenocarcinoma"],"prefix":"10.1136","volume":"52","author":[{"given":"J D","family":"Trimbath","sequence":"first","affiliation":[{"name":"Department of Medicine, the Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Griffin","sequence":"additional","affiliation":[{"name":"Department of Pathology, and Sidney Kimmel Comprehensive Cancer Center, the Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Romans","sequence":"additional","affiliation":[{"name":"Sidney Kimmel Comprehensive Cancer Center, the Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F M","family":"Giardiello","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Pathology, and Sidney Kimmel Comprehensive Cancer Center, the Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2003,6,1]]},"reference":[{"key":"2025121311043865000_52.6.903.1","unstructured":"Cancer Facts and Figures. Atlanta, GA: American Cancer Society, 2002."},{"key":"2025121311043865000_52.6.903.2","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1016\/0016-5085(92)90322-P","volume":"102","year":"1992","journal-title":"Gastroenterology"},{"key":"2025121311043865000_52.6.903.3","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930201)71:3<677::AID-CNCR2820710305>3.0.CO;2-#"},{"key":"2025121311043865000_52.6.903.4","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.20228"},{"key":"2025121311043865000_52.6.903.5","first-page":"278","volume":"80","year":"1998","journal-title":"J Natl Cancer Inst"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.52.6.903","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T19:04:49Z","timestamp":1765652689000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.52.6.903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6]]},"references-count":5,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2003,6,1]]},"published-print":{"date-parts":[[2003,6]]}},"alternative-id":["10.1136\/gut.52.6.903"],"URL":"https:\/\/doi.org\/10.1136\/gut.52.6.903","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,6]]}}}