{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:23:50Z","timestamp":1773005030496,"version":"3.50.1"},"reference-count":20,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[2003,7]]},"abstract":"\n Background and aims:<\/jats:bold>\n We tested if host gastric Lewis antigens and the\n babA2<\/jats:italic>\n genotype of\n Helicobacter pylori<\/jats:italic>\n correlated with clinicohistological outcome.\n <\/jats:p>\n \n Methods:<\/jats:bold>\n We enrolled 188 dyspeptic patients (45 with duodenal ulcer, 45 with gastric ulcer, and 98 with chronic gastritis) with\n H pylori<\/jats:italic>\n infection, proved by culture and gastric histology, reviewed by the updated Sydney system. Gastric expression of Lewis (Le) antigens Le\n a<\/jats:sup>\n , Le\n b<\/jats:sup>\n , Le\n x<\/jats:sup>\n , and Le\n y<\/jats:sup>\n was determined immunochemically to determine intensity (range 0\u20133). The corresponding 188\n H pylori<\/jats:italic>\n isolates were screened for\n babA2<\/jats:italic>\n genotype by polymerase chain reaction.\n <\/jats:p>\n \n Results:<\/jats:bold>\n All\n H pylori<\/jats:italic>\n isolates had a positive\n babA2<\/jats:italic>\n genotype. We identified Le\n a<\/jats:sup>\n in 33.5%, Le\n b<\/jats:sup>\n in 72.9%, Le\n x<\/jats:sup>\n in 86.2%, and Le\n y<\/jats:sup>\n in 97.4% of biopsies from these 188 patients. Patients who expressed Le\n b<\/jats:sup>\n had a higher\n H pylori<\/jats:italic>\n density than those who did not express Le\n b<\/jats:sup>\n (p<0.001). Among 139 patients who expressed Le\n b<\/jats:sup>\n ,\n H pylori<\/jats:italic>\n density increased with a higher Le\n b<\/jats:sup>\n intensity (p<0.05). Gastric atrophy decreased with Le\n b<\/jats:sup>\n intensity and thus resulted in lower\n H pylori<\/jats:italic>\n density in the antrum (p<0.05). For the 49 patients without gastric Le\n b<\/jats:sup>\n expression,\n H pylori<\/jats:italic>\n density was positively related with Le\n x<\/jats:sup>\n and Le\n a<\/jats:sup>\n expression (p<0.05).\n <\/jats:p>\n \n Conclusions:<\/jats:bold>\n Taiwanese\n H pylori<\/jats:italic>\n isolates are 100%\n babA2<\/jats:italic>\n genopositive. Gastric Le\n b<\/jats:sup>\n as well as Le\n x<\/jats:sup>\n intensity may be major determinants of\n H pylori<\/jats:italic>\n density. While lacking gastric Le\n b<\/jats:sup>\n expression, Le\n x<\/jats:sup>\n and Le\n a<\/jats:sup>\n were closely related to\n H pylori<\/jats:italic>\n colonisation.\n <\/jats:p>","DOI":"10.1136\/gut.52.7.927","type":"journal-article","created":{"date-parts":[[2003,6,11]],"date-time":"2003-06-11T14:27:04Z","timestamp":1055341624000},"page":"927-932","source":"Crossref","is-referenced-by-count":124,"title":["Host gastric Lewis expression determines the bacterial density of\n Helicobacter pylori<\/i>\n in\n babA2<\/i>\n genopositive infection"],"prefix":"10.1136","volume":"52","author":[{"given":"B-S","family":"Sheu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S-M","family":"Sheu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H-B","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A-H","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J-J","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2003,7,1]]},"reference":[{"key":"2025120600040094000_52.7.927.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70575-5"},{"key":"2025120600040094000_52.7.927.2","doi-asserted-by":"crossref","first-page":"4564","DOI":"10.1128\/iai.63.12.4564-4568.1995","volume":"63","year":"1995","journal-title":"Infect Immun"},{"key":"2025120600040094000_52.7.927.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70082-4"},{"key":"2025120600040094000_52.7.927.4","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.19.11533"},{"key":"2025120600040094000_52.7.927.5","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1128\/iai.64.6.2031-2040.1996","volume":"64","year":"1996","journal-title":"Infect Immun"},{"key":"2025120600040094000_52.7.927.6","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v113.pm9322503"},{"key":"2025120600040094000_52.7.927.7","first-page":"919","volume":"88","year":"1993","journal-title":"Am J Gastroenterol"},{"key":"2025120600040094000_52.7.927.8","doi-asserted-by":"publisher","DOI":"10.1126\/science.8018146"},{"key":"2025120600040094000_52.7.927.9","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5349.373"},{"key":"2025120600040094000_52.7.927.10","first-page":"1903","volume":"61","year":"2001","journal-title":"Cancer Res"},{"key":"2025120600040094000_52.7.927.11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.22.12778"},{"key":"2025120600040094000_52.7.927.12","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.7.2463-2465.2001"},{"key":"2025120600040094000_52.7.927.13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.1999.99295.x"},{"key":"2025120600040094000_52.7.927.14","first-page":"704","volume":"90","year":"2000","journal-title":"J Formos Med Assoc"},{"key":"2025120600040094000_52.7.927.15","first-page":"18","volume":"101","year":"2002","journal-title":"J Formos Med Assoc"},{"key":"2025120600040094000_52.7.927.16","doi-asserted-by":"publisher","DOI":"10.1126\/science.1069076"},{"key":"2025120600040094000_52.7.927.17","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018894606541"},{"key":"2025120600040094000_52.7.927.18","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"2025120600040094000_52.7.927.19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.130079797"},{"key":"2025120600040094000_52.7.927.20","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70082-9"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.52.7.927","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T08:04:07Z","timestamp":1765008247000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.52.7.927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7]]},"references-count":20,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2003,7,1]]},"published-print":{"date-parts":[[2003,7]]}},"alternative-id":["10.1136\/gut.52.7.927"],"URL":"https:\/\/doi.org\/10.1136\/gut.52.7.927","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,7]]}}}