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Endoscopic surveillance can be safely discontinued in mutation negative family members and surveillance or prophylactic surgery can be targeted to mutation positive members alone. Testing requires genetic counselling and written informed consent to prevent misunderstanding and to minimise untoward effects such as anxiety. Permanent surveillance and adequate prophylactic treatment for all mutation positive subjects and families is best ensured in national or regional polyposis registries with the capacity to take care of long term follow up from generation to generation.<\/jats:p>","DOI":"10.1136\/gut.52.suppl_2.ii19","type":"journal-article","created":{"date-parts":[[2003,3,21]],"date-time":"2003-03-21T19:46:53Z","timestamp":1048276013000},"page":"ii19-ii22","source":"Crossref","is-referenced-by-count":16,"title":["Genetic testing for polyposis: practical and ethical aspects"],"prefix":"10.1136","volume":"52","author":[{"given":"H J","family":"J\u00e4rvinen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2003,5,1]]},"reference":[{"key":"2025112111144489000_52.suppl_2.ii19.1","doi-asserted-by":"publisher","DOI":"10.1038\/328614a0"},{"key":"2025112111144489000_52.suppl_2.ii19.2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(81)90021-0"},{"key":"2025112111144489000_52.suppl_2.ii19.3","doi-asserted-by":"publisher","DOI":"10.1126\/science.8484120"},{"key":"2025112111144489000_52.suppl_2.ii19.4","doi-asserted-by":"publisher","DOI":"10.1038\/ng1193-279"},{"key":"2025112111144489000_52.suppl_2.ii19.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81333-1"},{"key":"2025112111144489000_52.suppl_2.ii19.6","doi-asserted-by":"publisher","DOI":"10.1038\/ng1197-271"},{"key":"2025112111144489000_52.suppl_2.ii19.7","doi-asserted-by":"publisher","DOI":"10.1038\/34432"},{"key":"2025112111144489000_52.suppl_2.ii19.8","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5366.1086"},{"key":"2025112111144489000_52.suppl_2.ii19.9","doi-asserted-by":"publisher","DOI":"10.1038\/88919"},{"key":"2025112111144489000_52.suppl_2.ii19.10","unstructured":"Bussey HJR. 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