{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:49:48Z","timestamp":1790232588622,"version":"4.1.0"},"reference-count":35,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    plays a decisive role in the pathogenesis of gastric marginal zone B cell lymphoma of mucosa associated lymphoid tissue (MALT), and eradication therapy has become a widely accepted initial treatment of stage I disease.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    To determine the long term outcome of patients undergoing exclusive\n                    <jats:italic>H pylori<\/jats:italic>\n                    eradication therapy.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Design:<\/jats:bold>\n                    A prospective series of patients with newly diagnosed marginal zone B cell lymphoma of MALT.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Setting:<\/jats:bold>\n                    Multicentre study in Germany and Austria.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Patients:<\/jats:bold>\n                    Ninety five patients; 90 of these (five lost to follow up) with a mean age of 54.3 (27\u201385) years were followed up for at least 12 months.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Intervention:<\/jats:bold>\n                    Complete staging work up revealing stage I disease and\n                    <jats:italic>H pylori<\/jats:italic>\n                    infection. Patients received triple therapy (OMC: omeprazole 20 mg twice daily, metronidazole 400 mg twice daily, and clarithromycin 250 mg twice daily; or OAC: omeprazole 20 mg twice daily, amoxycillin 1000 mg twice daily, and clarithromycin 500 twice daily) for one week.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Median follow up was 44.6 (12\u201389) months.\n                    <jats:italic>H pylori<\/jats:italic>\n                    was successfully eradicated in 88 patients (98%); in two patients eradication therapy failed. Long term outcome was characterised by complete regression of lymphoma in 56 patients (62%), minimal residual disease in 17 patients (18%), partial remission in 11 patients (12%), no change in four patients (4%), and progressive disease in two patients (2%). Four patients with complete remission relapsed after 6, 8, 8, and 15 months, one revealing reinfection by\n                    <jats:italic>H pylori<\/jats:italic>\n                    . Regression rate was higher in stage I1 disease compared with stage I2, as diagnosed by endoscopic ultrasound.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    The majority of patients with low grade gastric MALT lymphoma treated by exclusive\n                    <jats:italic>H pylori<\/jats:italic>\n                    eradication have a favourable long term outcome, offering a real chance of cure.\n                  <\/jats:p>","DOI":"10.1136\/gut.53.1.34","type":"journal-article","created":{"date-parts":[[2003,12,18]],"date-time":"2003-12-18T18:23:28Z","timestamp":1071771808000},"page":"34-37","source":"Crossref","is-referenced-by-count":272,"title":["Long term outcome of patients with gastric marginal zone B cell lymphoma of mucosa associated lymphoid tissue (MALT) following exclusive\n                    <i>Helicobacter pylori<\/i>\n                    eradication therapy: experience from a large prospective series"],"prefix":"10.1136","volume":"53","author":[{"given":"W","family":"Fischbach","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M-E","family":"Goebeler-Kolve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Dragosics","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Greiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Stolte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2003,12,18]]},"reference":[{"key":"2025120523211802000_53.1.34.1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.42.12.1269"},{"key":"2025120523211802000_53.1.34.2","first-page":"135","volume":"23","year":"1988","journal-title":"Scand J Gastroenterol"},{"key":"2025120523211802000_53.1.34.3","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92035-Z"},{"key":"2025120523211802000_53.1.34.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70028-3"},{"key":"2025120523211802000_53.1.34.5","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90280-G"},{"key":"2025120523211802000_53.1.34.6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199405053301803"},{"key":"2025120523211802000_53.1.34.7","first-page":"1357","volume":"89","year":"1994","journal-title":"Am J Gastroenterol"},{"key":"2025120523211802000_53.1.34.8","first-page":"572","volume":"70","year":"1994","journal-title":"Lab Invest"},{"key":"2025120523211802000_53.1.34.9","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91408-E"},{"key":"2025120523211802000_53.1.34.10","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199602)178:2<122::AID-PATH486>3.0.CO;2-D"},{"key":"2025120523211802000_53.1.34.11","first-page":"44D","volume":"14","year":"2000","journal-title":"Can J Gastroenterol"},{"key":"2025120523211802000_53.1.34.12","unstructured":"Isaacson PG, Norton AJ. 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